Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate sustainable approaches into their work. Sections cover different aspects of green and sustainable drug development from design to disposal, including computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, this book provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs.
This will be a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science.
- Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues
- Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs
- Presents individual chapters written by renowned experts with diverse backgrounds
- Reflects research in practice through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project
Part I. Health Concerns, Risk Assessment and Environmental Monitoring of Pharmaceutical Pollutants 1. Types of Pharmaceutical Pollutants and their Environmental Risk Assessment 2. Novel Analytical Methods for Environmental Monitoring 3. Antibiotic Resistance and Preventative Measures 4. Ecotoxicogenomics for Understanding the Effects of Pharmaceutical Pollution 5. Drugs and Drug Byproducts as Endocrine Disruptors 6. Accumulation of Drug Residues in Food
Part II. Computational Tools of Green Drug Design 7. Data Mining and Machine Learning in Drug Discovery and Development 8. Virtual Screening Techniques in Pharmaceutical Research 9. In Silico Toxicology 10. Quantum Chemistry for the Environment
Part III. Green Sourcing of Drugs and Drug Candidates 11. Renewable Resources 12. Sustainable Separations 13. Green Solvents for Drug Synthesis 14. Green Synthetic Methods in Drug Discovery and Development 15. Green Manufacturing of Pharmaceuticals 16. Green Metrics of Drug Synthesis
Part IV. New Chemical Directions to Reducing Drugs and their Byproducts in the Environment 17. Sustainable Nanotechnology 18. Novel Water Treatment Technologies 19. Green Peptide-based Drugs 20. Multi-Target Approaches in Medicinal Chemistry 21. Directed Evolution for the Production of Pharmaceuticals 22. Oligonucleotide Therapeutics 23. Bioorthogonal Chemistry 24. Antibody-Drug Conjugates for Targeted Delivery
Dr Marianna Török complete her studies in Physical Chemistry and Biochemistry at the University of Szeged (Hungary), University of Southern California Los Angeles (USA) and Massachusetts Institute of Technology (USA). She is an associate professor at the Department of Chemistry, University of Massachusetts Boston (USA), a public university strongly committed to Green Chemistry education and research, and the first school to offer a doctoral degree via the PhD in Chemistry/Green Chemistry Track. Her research interest includes the interconnection of Medicinal Chemistry and Green Chemistry, and she is a co-author of several reviews and research articles in this field