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Sarcopenia. Molecular Mechanism and Treatment Strategies

  • Book

  • July 2021
  • Elsevier Science and Technology
  • ID: 5238322

Sarcopenia: Molecular Mechanism and Treatment Strategies provides answers and guidance on a disease that has serious health consequences in terms of fractures, frailty, disability and diminished quality of life. Written by experts around the world, this book is for all those that care for aging populations. As the global population ages, sarcopenia remains a therapeutic challenge and major public health concern. Difficulties in defining sarcopenia as a clinical phenotype remain and have hindered treatment.

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Table of Contents

1. The definition of sarcopenia and the physical measures being associated with sarcopenia 2. Mitochondrial dysfunction linking to sarcopenia 3. The regulation of MicroRNA for sarcopenia 4. The relationship between neuromuscular junction and sarcopenia 5. The functional role of satellite cells in sarcopenic muscle 6. The molecular mechanisms of age-related anabolic resistance 7. The autophagic defect in sarcopenic muscle 8. Mitophagy system in sarcopenic muscle 9. Sarcopenia and the inflammatory cytokines 10. Skeletal muscle ECM remodeling and sarcopenia 11. Underlying mechanisms of sarcopenic obesity 12. Dysphagia in sarcopenia and cachexia 13. Under adjustment 14. Molecular mechanism of exercise for combating sarcopenia 15. Dietary approaches to maintain muscle mass 16. Pharmacological strategy for sarcopenia 17. Stem cells and sarcopenia with some translational aspect 18. Metabolic reprogramming attenuating sarcopenia


Kunihiro Sakuma Physiologist, Tokyo Institute of Technology, Japan. Professor Kunihiro Sakuma is a Physiologist working in the field of skeletal muscle at the Tokyo Institute of Technology in Japan. He began his scientific career in the Department of Physiology, Aichi Human Science Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and the attenuating strategy of sarcopenia (age-related muscle atrophy). Preventing sarcopenia is critical for maintaining a high quality of life in the aged population.