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Epigenetics and Metabolomics. Translational Epigenetics Volume 28

  • Book
  • August 2021
  • Elsevier Science and Technology
  • ID: 5275377

Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare.

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Table of Contents

CHAPTER 1 Metabolomics techniques: A brief update
CHAPTER 2 Integration of epigenomics and metabolomics: From biomarkers discovery to personalized medicine
CHAPTER 3 Aging-associated changes in metabolic regulation of epigenetic modifications and gene expression
CHAPTER 4 Epigenetic and metabolic changes in traumatic brain injury
CHAPTER 5 Metabolic regulation in urological tumors: Interplay with epigenetics and epitranscriptomics
CHAPTER 6 Multiomics approach for precision wellness
CHAPTER 7 Oncogene: An epigenetic regulation
CHAPTER 8 Epigenetic regulations in gastrointestine: Implications on sensitivity to ionizing radiation, inflammatory diseases, and cancer development
CHAPTER 9 Epigenetics of epithelial to mesenchymal transition (EMT) in cancer
CHAPTER 10 Nutrients seminal role in the development and epigenetic reprogramming during the first 1000 days of life
CHAPTER 11 Epigenetic mechanisms of hepatocellular carcinoma progression: Potential therapeutic opportunities
CHAPTER 12 Translational epigenetics in neurodegenerative diseases
CHAPTER 13 Host-epigenetics-microbiota: A tripartite interaction in health and disease
CHAPTER 14 Epigenetics in cardiovascular complications
CHAPTER 15 Epigenetics and viral infectious diseases
CHAPTER 16 Metabolic profiling leading to clinical phenomics: From bench to bedside
CHAPTER 17 Epigenetic insights for wound healing mechanism
CHAPTER 18 Role of metabolomics to investigate combined effect of radiation and burn
CHAPTER 19 Advances and prospects of epigenetics in plants


Paban K. Agrawala Radiation Epigenetics Division, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India. Dr. Paban K. Agrawala Ph.D is a Scientist in the Radiation Epigenetics Division at the Institute of Nuclear Medicine and Allied Sciences in New Delhi, India, and previously was a Post doctoral Research Associate at Brookhaven National Lab, New York, USA. Dr. Agrawala is a member of the Indian Society for Radiation Biology, as well the Flowcytometry Society of India. He has published widely in such peer reviewed journals as the International Journal of Radiation Biology; Frontiers in Immunology; Current Topics in Medicinal Chemistry; and the Journal of Environmental Pathology, Toxicology, and Oncology. His current research focuses on understanding the epigenetic changes, especially histone acetyltion status, following exposure to ionizing radiation. Poonam Rana Nuclear Medicine and Allied Sciences, Ministry of Defence, Timarpur, New Delhi, India. Dr. Poonam Rana Phd is a Senior Scientist at the Institute of Nuclear Medicine & Allied Sciences, under Ministry of Defence, Delhi, India. She received her PhD at the CCS Haryana Agricultural University in Hisar, India. Her focus of research is applications of metabolomics and imaging in identification of biomarkers for traumatic brain injury and radiation exposure during combat emergencies. She has published widely in such peer reviewed journals as the Scientific Reports, Metabolomics, Journal of Neuroendocrinology, International Journal of Radiation Biology, Journal of Neuroscience Research, and Chemical Biological Interactions.