+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

Proteolytic Signaling in Health and Disease

  • Book

  • October 2021
  • Elsevier Science and Technology
  • ID: 5308651

In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called 'protease web', and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events.

Please Note: This is an On Demand product, delivery may take up to 11 working days after payment has been received.

Table of Contents

1. Proteolytic signalling: an introduction

Andr? Zelanis, Uilla Barcick and Maur?cio F. Camacho

2. Ubiquitin-ligases: proteolytic signaling, protein turnover, and disease

Felipe Roberti Teixeira, Patricia Passos, Camila Correia, Caio Almeida, Valentine Spagnol and Isabela Fernanda Morales Martins

3. Lysosomal proteases and their role in signaling pathways

Rebecca A.B. Burton, Samuel Bose and Thamali Ayagama

4. Antigen processing and presentation through MHC molecules

Niels Olsen Saraiva C?mara, Tamisa Honda and Barbara Padovani

5. Proteolytic processing in autophagy

Jo?o Agostinho Machado-Neto and Andrei Leit?o

6. Proteolysis in inflammatory diseases

Antoine Dufour and Luiz de Almeida

7. Proteolytic processing of laminin and the role of cryptides in tumoral biology

Vanessa Morais Freitas, Ruy Gastaldoni Jaeger and Adriane Sousa de Siqueira

8. Proteolytic signaling in wound healing

Ulrich auf dem Keller, Konstantinos Kalogeropoulos and Louise Bundgaard

9. Proteinases disbalance in oral cancer and other diseases

Adriana Franco Paes Leme

10. 'Omics' approaches for investigating protease degradomes in complex biological matrices

Pitter F. Huesgen and Maithreyan Kuppusamy

11. Protease web

Nikolaus Fortelny and Wolfgang Esser-Skala

12. The puzzle of proteolytic effects in hemorrhage induced by Viperidae snake venom metalloproteinases

Milene Menezes, Dilza Trevisan-Silva, Daniela Cajado De Oliveira Souza Carvalho and Jessica de Alcantara Ferreira


Andre Zelanis Assistant professor of Proteomics and Systems Biology, and Head, Functional Proteomics Laboratory, Department of Science and Technology, Federal University of Sao Paulo, Sao Jose dos Campos, Brazil. Dr. Andr� Zelanis is Assistant professor of Proteomics and Systems Biology, and Head of the Functional Proteomics Laboratory at the Department of Science and Technology, Federal University of S�o Paulo, S�o Jos� dos Campos, Brazil. His research focuses in proteomics and mass spectrometry-based approaches to uncover protease function in biological signaling pathways. Currently his lab is using proteomics to explore the repertoire of substrates (degradome) of proteases secreted by melanoma cells in culture and evaluating proteolytic processing events in the plasma of patients with metastatic melanoma. He has published widely in such peer reviewed journals as the Journal of Proteome Research and Comparative Biochemistry and Physiology.