Research and Clinical Applications of Targeting Gastric Neoplasms

Table of Contents

1. Stomach corpus stem cells in homeostasis, tissue repair, and cancer 2. The role of inflammation in gastric tumorigenesis 3. Unravelling the pro-tumorigenic role of innate immune pattern recognition receptors in the gastric compartment 4. Helicobacter pylori-induced gastric carcinogenesis 5. The role of Helicobacter pylori CagA oncoprotein in neoplastic transformation of gastric epithelial cells 6. Epigenetic aberrations by Epstein-Barr virus infection to develop gastric cancer 7. In vivo and in vitro models of gastric cancer 8. Premalignant lesions of the stomach and management of early neoplastic lesions 9. Updated perspective and directions on hereditary diffuse gastric cancer 10. Systems biology and molecular characterization of subtypes to guide targeted therapies in gastric cancer 11. Current state of chemotherapy and immunotherapy regimens in gastric cancer 12. Case studies highlighting the multiple facets of gastric cancer: one diagnosis, multiple approaches1. Stomach corpus stem cells in homeostasis, tissue repair, and cancer 2. The role of inflammation in gastric tumorigenesis 3. Unravelling the pro-tumorigenic role of innate immune pattern recognition receptors in the gastric compartment 4. Helicobacter pylori-induced gastric carcinogenesis 5. The role of Helicobacter pylori CagA oncoprotein in neoplastic transformation of gastric epithelial cells 6. Epigenetic aberrations by Epstein-Barr virus infection to develop gastric cancer 7. In vivo and in vitro models of gastric cancer 8. Premalignant lesions of the stomach and management of early neoplastic lesions 9. Updated perspective and directions on hereditary diffuse gastric cancer 10. Systems biology and molecular characterization of subtypes to guide targeted therapies in gastric cancer 11. Current state of chemotherapy and immunotherapy regimens in gastric cancer 12. Case studies highlighting the multiple facets of gastric cancer: one diagnosis, multiple approaches

Authors

Brendan Jenkins Head, Cancer and Immune Signaling Laboratory, Hudson Institute of Medical Research; Professor, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia. Prof. Brendan Jenkins is an internationally renowned researcher who studies inflammation-associated cancers of the stomach, pancreas and lung, the latter of which is also linked to chronic obstructive pulmonary disease (COPD). His vision is to identify and develop new diagnostics and immunotherapies for these diseases. Prof. Jenkins is head of the Cancer and Immune Signaling Laboratory of the Hudson Institute of Medical Research in Victoria, Australia, and he is also a Professor in the Faculty of Medicine, Nursing and Health Sciences of Monash University. He has received over 20 national and international awards for his research and is a Senior Research Fellow of the Australian National Health and Medical Research Council (2014-2023); prior to that he held a prestigious Viertel Senior Medical Research Fellowship (2009-2013). He received his PhD in Medicine from the University of Adelaide, South Australia in 1998.