+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics

  • Book
  • February 2022
  • Elsevier Science and Technology
  • ID: 5342277

Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics is an essential read for anyone working in pain management. The book addresses the onset of pain, the cause of the pain, and the administration of analgesia or anesthesia. The etiology of pain is complex and multi-factorial, which is made more complex with the use of analgesics and local or general anesthetics. This volume works to clarify all of the subjects pertinent to anesthesia and the brain, from their variety, modes of action, and adverse effects.

Table of Contents

I. Drugs and agents used in anesthesia and analgesia 1. Anesthesia for malignant hyperthermia susceptible patients 2. Use of dextran in regional anesthesia 3. Intraperitoneal local anesthetic agents in the management of post-operative pain 4. Automatic control of anesthesia via different vital signs 5. Non-opioid based analgesia in otolaryngology

II. Mechanisms of action of drugs 6. Buprenorphine: mechanisms and applications 7. Caffeine usage in pain management 8. Chloroprocaine: features and applications 9. Clonidine: features and applications 10. An excursion into secondary pharmacology of fentanyls with potential implications for drug design: s1 receptor 11. Isoflurane: mechanisms and applications 12. The lidocaine patch: features and applications: post-thoracotomy pain and beyond 13. Memantine: features and application to chronic pain control 14. Midazolam: Perioperative administration 15. Intravenous paracetamol: features and applications 16. Prilocaine: mechanisms and applications 17. Sevoflurane: features and use in topical application for wound care 18. Tramadol as an analgesic

III. Adverse effects, reactions and outcomes 19. Long-term effects of anaesthesia on the brain: an update on neurotoxicity 20. Neuraxial labour analgesia and breast feeding 21. Mechanistic Overview of How Opioid Analgesics Promote Constipation 22. Cognitive-behavioral therapy for opioid use disorder and chronic pain 23. Preoperative opioid and benzodiazepines: impact on adverse outcomes 24. Anesthetics, Malignant hyperthermia syndrome and Kv7 channels 25. Problems with epidural catheter 26. Headache after neuroaxial blocks: a focus on combined-epidural anesthesia 27. Liposomal bupivacaine, pain relief and adverse events 28. Adverse events associate with analgesics: a focus on paracetamol use

IV. Novel and non-pharmacological aspects and treatments 29. Acronychia pedunculata leaves and usage in pain 30. Adansonia digitata and use in neuropathic pain: prostaglandins and beyond 31. Andrographis paniculata standardized extract (ParActin) and pain 32. Capsaicin: features usage in diabetic neuropathic pain 33. Cola nitida and Pain reliefLawrence 34. Analgesic effects of Ephedra Herb extract and ephedrine alkaloids-free Ephedra Herb extract (EFE) 35. Euphorbia bicolor (Euphorbiaceae) Latex Phytochemicals and applications to analgesia 36. Pain relieving activity of muntingia calabura l.: elucidation of possible mechanisms of action and identification of responsible phytoconstituents 37. Resolving neuroinflammation and pain with Maresin 1, a specialized pro-resolving lipid mediator 38. Therapeutic role of naringenin to alleviate inflammatory pain 39. Analgesic properties of Solanum paniculatum and S.torvum extracts 40. Dietary constituents contribute to local anesthetic agent: neurophysiologicals mechanism of nociceptive pain 41. Pain response following prenatal stress and its modulation by antioxidants 42. Physical activity and fitness in the prevention of musculoskeletal pain in youth 43. Linking aerobic exercise and childhood pain alleviation: a narrative 44. Physical activity and exercise in the management of musculoskeletal pain: a focus on fibromyalgia 45. Spinal cord stimulation and limb pain 46. Effectiveness of neural mobilization on pain and disability in individuals with musculoskeletal disorders 47. Virtual reality and applications to treating neck pain 48. Virtual reality-induced analgesia and dental pain 49. Vibrotactile devices, DentalVibe and local anesthesiaElitsa 50. Cooled radiofrequency ablation (CRFA) and osteoarthritis treatment for pain 51. Non-pharmacologic analgesic therapies: a focus on photobiomodulation, acustimulation and cryoanalgesia (ice) therapy 52. New coping strategies and self-education for chronic pain management: e-health 53. Postoperative Pain Management Truncal blocks in obstetric and gynecologic surgery


Rajkumar Rajendram Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King's College London, UK. Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy's, King's, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King's College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts. Victor R. Preedy Emeritus Professor, King's College London; Professor, King's College Hospital, London, UK. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is Emeritus Professor of Nutritional Biochemistry, at King's College London and Professor of Clinical Biochemistry (Hon) at King's College Hospital. He was the long-term Director of the Genomics Centre at King's College London from 2006 to 2020. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof. Preedy is a leading expert on the science of health and has a long-standing interest in dietary and plant-based components. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes. Vinood B. Patel Reader, University of Westminster, London, UK. Vinood B. Patel, BSc, PhD, FRSC, is currently Reader in Clinical Biochemistry at the University of Westminster. He presently directs studies on metabolic pathways involved in liver disease, particularly related to mitochondrial energy regulation and cell death. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of liver disease and understanding mitochondrial oxidative stress in Alzheimer's disease and gastrointestinal dysfunction in autism. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. In 2014 Dr. Patel was elected as a Fellow to The Royal Society of Chemistry. Colin R. Martin Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK. Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).