Posttraumatic Epilepsy. Basic and Clinical Aspects

Table of Contents

1. History of posttraumatic epilepsy 2. Epidemiology of posttraumatic epilepsy 3. Neuropathology of posttraumatic epilepsy 4. Clinical trials of agents to prevent posttraumatic epilepsy 5. Surgical treatment of posttraumatic epilepsy 6. Animal models of traumatic brain injury 7. Incidence of posttraumatic epilepsy in animal models of traumatic brain injury 8. Cellular and molecular changes in animal models of posttraumatic epilepsy 9. Blood-brain barrier disruption and posttraumatic epilepsy 10. Inflammation and posttraumatic epilepsy 11. Biomarkers and treatment trials in animal models to prevent posttraumatic epilepsy 12. Therapeutic targets and future directions

Authors

Carrie R. Jonak Neuroscience reseracher, Division of Biomedical Sciences, University of California, Riverside, USA. Carrie R. Jonak (research associate) is a neuroscience researcher in Dr. Binder's laboratory, in the Division of Biomedical Sciences at the University of California, Riverside. Allison R. Peterson Ph.D. candidate, Division of Biomedical Scienecs at the University of California, Riverside, USA. Allison Peterson is a Ph.D. candidate (graduate student in Biomedical Sciences) in Dr. Binder's laboratory in the Division of Biomedical Scienecs at the University of California, Riverside. Devin K. Binder Center for Glial-Neuronal Interactions, Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, USA. Originally from the Bay Area, Devin K. Binder went to Harvard University as an undergraduate, where he studied biology, anthropology, and neuroscience. He was awarded the Hoopes Prize at Harvard for his summa cum laude senior honors thesis "Serotonin and behavioral state.� Deciding to pursue both neuroscience and clinical medicine, he enrolled in the M.D./Ph.D. program at Duke University. At Duke, he graduated 1st in his medical school class, and contributed to epilepsy neuroscience with his Ph.D. dissertation "The functional role of neurotrophins in the kindling model of epilepsy.� Subsequently, Binder completed a one-year internship in general surgery at the University of California, San Francisco, and a six-year residency in neurological surgery at UCSF. At UCSF, he did a one-year fellowship in the laboratory of Dr. Alan Verkman, leader in the field of aquaporin biology. Following residency, Binder was awarded the Van Wagenen neurosurgical fellowship for one year of neuroscience and neurosurgery at the University of Bonn. There, he did another fellowship in the laboratory of Dr. Christian Steinh�user, Director of the Institute for Cellular Neuroscience at the University of Bonn. Following a three-year stint at the University of California, Irvine, in the Departments of Neurological Surgery and Anatomy & Neurobiology, Binder joined the Division of Biomedical Sciences at the University of California, Riverside School of Medicine in January 2010. Binder runs the NIH-funded Translational Neuroscience Laboratory, and conducts research on astrocytes, epilepsy, and neurophotonics. Binder has been publishing in the epilepsy field since the 1990s, and has publications since 2004 relevant to astrocyte contribution to seizures and epilepsy. He is the previous co-author of 3 books, 2 related to epilepsy, currently holds 2 NIH grants related to epilepsy, and sits on leadership committees of the American Epilepsy Society.