Inflammasome Biology. Fundamentals, Role in Disease States, and Therapeutic Opportunities

Table of Contents

Part I Fundamentals of Inflammasome Biology
1. Overview of inflammatory processes at cellular level
2. Inflammasome formation and triggers
3. Cellular signaling, molecular activation and regulation of the NLRP1 inflammasome
4. Cellular signaling, molecular activation and regulation of the NLRP3 inflammasome
5. Cellular signaling, molecular activation and regulation of the NLRP6 inflammasome
6. Cellular signaling, molecular activation and regulation of the NLRC4 inflammasome
7. Cellular signaling, molecular activation and regulation of the AIM2 inflammasome
8. Cellular signaling, molecular activation and regulation of the Pyrin inflammasome
9. Cellular signaling, molecular activation and regulation of the non-canonical inflammasome
10. Cellular signaling, molecular activation and regulation of auto-active inflammasomes
11. Autophagy and the inflammasome
12. Inflammasome effector functions
13. Inflammatory caspases
14. Structural aspects of inflammasomes
15. Evolutive aspects of inflammasomes

Part II inflammasome role in disease processes
16. The inflammasome in cardiovascular diseases
17. Inflammasome implications in metabolic disorders
18. Inflammasome in venous thromboembolic disorders
19. Inflammasomes and neurodegenerative diseases
20. Inflammasome implication in diseases of the respiratory system
21. Inflammasomes and their regulation in oral disease
22. Inflammasomes in inflammatory bowel disease pathogenesis
23. Inflammasome induced inflammation and fibrosis in liver
24. Inflammasomes in sepsis
25. The Inflammasome in viral, bacterial and fungal infections
26. Autoinflammatory syndromes
27. The inflammasome in graft-versus-host disease
28. Implication of the inflammasomes in rheumatic diseases
29. The inflammasomes in kidney disease
30. Inflammasomes and cancer
31. Inflammasomes in the pathobiology of degenerative retinopathies.

Part III Inflammasome crosstalk in Cell Death
32. Regulation of pyroptosis by inflammasomes.
33. Crosstalk between necroptosis and inflammasome.
34. Apoptosis and inflammasome regulation
35. Implication of inflammasomes regulating different types of cell death
36. Regulation of neutrophil NETosis by inflammasomes

Part IV Therapeutic Opportunities
37. Therapeutic opportunities targeting the inflammasome
38. Development of selective inflammasome Inhibitors
39. Natural compounds blocking inflammasomes
40. Inhibitors targeting inflammasome effectors
41. Multi-inflammasome inhibitors

Authors

Pablo Pelegrin Principal Investigator, Molecular Inflammation Research Group, Murcia BioHealth Research Institute-Hospital "Virgen de la Arrixaca�, Murcia, Spain. Dr. Pablo Pelegrin is the principal investigator of the molecular inflammation research group at the Murcia BioHealth Research Institute-Hospital "Virgen de la Arrixaca� in, Murcia, Spain. He has postdoctoral degrees from both the University of Manchester (UK), and from the University of Sheffield (UK). His PhD in developmental immunology was obtained with the University of Murcia. He is an honorary lecturer at the University of Manchester, and Editor of the Inflammasome Journal, published by De Gruyter Open. Dr. Pelegrin has researched the Inflammasome for the past 15 years and is one of the most prolific researchers in this multidisciplinary research area.