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Advances in Organic Synthesis: Volume 17

  • Book
  • July 2022
  • Bentham Science Publishers Ltd
  • ID: 5645227

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field.

Contents of this volume include these 6 reviews:

  • Multicomponent synthesis of heterocycles by microwave irradiation
  • Stereoselective procedures for the synthesis of olefines
  • Advanced microwave assisted organic synthesis method in organic chemistry
  • Five and six-membered n-heterocycle rings from diaminomaleonitrile
  • Peptidomimetics: current and future perspectives on hiv protease inhibitors
  • A review on synthesis, chemistry, and medicinal properties of benzothiazines and their related scaffolds

Table of Contents

Chapter 1 Multicomponent Synthesis Of Heterocycles By Microwave Irradiation
  • Introduction
  • Microwave Chemistry
  • Origin
  • Microwave Devices
  • Microwave Heating Mechanism
  • Dipolar Polarization Mechanism
  • Ionic Conduction Mechanism
  • Microwave Effects
  • Reaction-Medium Effects
  • Specific Microwave Effects
  • Thermal Effects
  • Microwave Versus Classical Heating
  • Advantages And Disadvantages Of The Microwave Heating
  • Microwave-Assisted Organic Synthesis
  • Multicomponent Reactions (Mcrs)
  • Heterocyclic Compounds
  • Five - Membered Heterocycles
  • Five-Membered Heterocyclic Compounds With Single Heteroatoms
  • Five-Membered Heterocyclic Compounds With Two Or More Heteroatoms
  • Six-Membered Heterocycles
  • Six-Membered Heterocyclic Compounds With Mono Heteroatom
  • Six-Membered Heterocycles With Two Heteroatoms
  • Fused Heterocycles
  • Conclusion
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgement
  • List Of Abbreviations
  • References
Chapter 2 Stereoselective Procedures For The Synthesis Of Olefines 53 Introduction
  • Isomerism In Alkenes
  • Cis V/S Trans Nomenclature
  • (E). Ve (Z) Nomenclature
  • The Biological Significance Of Alkenes
  • Synthesis Of Alkenes And Stereoselectivity
  • The Elimination Reactions
  • The Reduction Of Alkynes
  • The Julia Olefination
  • The Peterson Elimination
  • The Ramberg-Bäcklund Reaction
  • The Wittig Reaction
  • I Ii Alice Rinky Robert, Ganja Himavathi And Maddila Suresh Haydar Göksu Olefin Metatez (Grubb’S Catalyst)
  • Metal Catalyzed Stereoselective Synthesis
  • Concluding Remarks
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgement
  • References
Chapter 3 Advanced Microwave Assisted Organic Synthesis Method In Organic Chemistry
  • Introduction
  • Microwave-Assisted Organic Synthesis In Aqueous Medium
  • Cross-Coupling Reaction
  • Suzuki-Miyaura Reaction
  • Sonogashira Reaction
  • Mizoroki - Heck Reaction
  • Preparation Of Heterocyclic Compounds
  • Nitrogen-Containing Heterocycles
  • Heterocycles Having Sulphur
  • Oxygen-Containing Heterocyclic Compounds
  • Linkage Of Carbon-Heteroatom
  • Preparation Of Amides
  • Activation Of C-H Group
  • Preparation Of The Derivatives Of Urea
  • Miscellaneous Reactions
  • Oxidation
  • Oxidation Of Alcohols
  • Microwave-Accelerated Oxidation Of Cyclohexane
  • Microwave-Accelerated Oxidation Of 1- Or 2-Phenylethanol
  • Microwave-Accelerated Oxidation Of Hydroxymethyl Furfural To Added Value Compounds Over A Ruthenium-Based Catalyst
  • Microwave-Assisted Oxidation Of Cyclohexane
  • Reduction
  • Reduction Of Aldehydes And Ketones
  • Reduction Of Nitroaromatic Compounds
  • Reduction Of Nitro Compounds
  • Reduction Of Ketones
  • Reduction Of Organic Compounds
  • Reductive Amination
  • Cascade Reduction-Condensation Reactions
  • Reduction Of Isatin
  • Conclusion
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgements
  • References
Chapter 4 Five And Six-Membered N-Heterocycle Rings From Diaminomaleonitrile
  • Manish Srivastava, Anjali Banger, Ravina Yadav, Anamika Srivastava, Jaya Dwivedi And Varun Rawat Amal Al-Azmi Introduction
  • Synthesis Of Five-Membered Rings
  • Synthesis Of Imidazoles
  • Synthesis Of 1,2,3-Triazoles
  • Synthesis Of Telluradiazoles
  • Synthesis Of Six-Membered Rings
  • Synthesis Of Pyrazines
  • Synthesis Of Pyrimidines
  • Concluding Remarks
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgements
  • References
Chapter 5 Peptidomimetics: Current And Future Perspectives On Hiv Protease Inhibitors
  • Introduction To Hiv Genome
  • Antiretroviral Therapy And Significance Of Peptidomimetics
  • Synthetic Approaches Towards Substrate-Guided Hiv-1 Protease Inhibitors
  • Basis For The Substrate-Based Design Of Hiv Inhibitors
  • Synthetic Approaches To Peptidomimetics Against Hiv-1 Protease
  • Synthetic Approaches Towards Hiv-1 Protease Dimerization Inhibitors
  • Synthetic Approaches Towards Hiv-1 Tat-Tar Rna Interface Inhibitors
  • Synthetic Approaches Towards Hiv-1 Capsid (Ca) Inhibitors
  • Synthetic Approaches Towards Hiv-1 Glycoprotein Gp120/Gp41 Inhibitors
  • Synthetic Approaches Towards Other Hiv-1 Inhibitors
  • Cd4 Receptor Based Peptidomimetics
  • P6Gag Region-Tsg101 Serived Peptidomimetics
  • Hiv-1 Coreceptor Based Approaches For Peptidomimetics
  • Gelatinase-Based Hiv Inhibitors
  • Prodrug Approaches For Hiv-1 Protease Inhibitors
  • Miscellaneous Hiv Inhibitors
  • Theoretical Calculations
  • Strategies To Be Considered In Design Of Hiv-1/Hiv-2 Protease Inhibitors
  • Hiv-2 Protease And Other Target-Based Inhibitors
  • Discussion
  • Opinions From Our Interest
  • Summary And Perspectives
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgements
  • References
Chapter 6 A Review On Synthesis, Chemistry, And Medicinal Properties Of Benzothiazines And Their Related Scaffolds
  • Introduction
  • Prathama S Mainkar, Surender Singh Jadav And Kiranmai Nayani Abdulrahman S. Alharbi, Abeer N. Al-Romaizan And Reda M. Abdel-Rahman Synthesis
  • 1,2-Benzothiazine Derivatives
  • 2,1-Benzothiazine Derivatives
  • 1,3-Benzothiazine Derivatives
  • 3,1-Benzothiazine Derivatives
  • 1,4-Benzothiazine Derivatives
  • Medicinal Properties Of Benzothiazines
  • 1,2-Benzothiazines
  • 2,1-Benzothiazines
  • 1,3-Benzothiazines
  • 3,1-Benzothiazines
  • 1,4-Benzothiazines
  • Conclusion
  • Consent For Publication
  • Conflict Of Interest
  • Acknowledgements
  • References
  • Subject Index

Author

  • Atta-ur-Rahman