Mitochondria are multifunctional organelles that actively participatein the immune-inflammatory response in various pathologies. This volume updates readers onknowledge about mitochondria function. The editors have compiled six chaptersabout inflammation in its broadest sense, with contributions from active groupsof cell biologists, infectologists and pathologists.
The chapters in this volume focus on research related to five notablediseases:(1) two diseases (one bacterial and one viral) in which theexacerbation of the inflammatory response can lead to neuropathies: leprosy(one of the oldest diseases in the world) and Zika fever (a disease relativelynew in Brazil) (2) three diseases (two bacterial and one viral) in which theexacerbation of the inflammatory response can lead to irreversible lung damagethat can cause rapid death: tuberculosis, pneumonia and the most recent globaldisease, COVID- 19. New information about mitochondrial biology is presented, such as theeffect of aerobic physical exercise as a stimulator for mitochondriamultiplication, and the role of mitochondrial damage in inducing immune-inflammatoryresponses to pathogens.
The contents shed light on mitochondrial biochemicalpathways that could serve as potential therapeutic targets. This is an important reference for scholars (cell biologists,microbiologists) in universities, hospitals and scientific research centersworking on biological and biomedical problems, and for health professionalsinvolved in infection control.
The chapters in this volume focus on research related to five notablediseases:(1) two diseases (one bacterial and one viral) in which theexacerbation of the inflammatory response can lead to neuropathies: leprosy(one of the oldest diseases in the world) and Zika fever (a disease relativelynew in Brazil) (2) three diseases (two bacterial and one viral) in which theexacerbation of the inflammatory response can lead to irreversible lung damagethat can cause rapid death: tuberculosis, pneumonia and the most recent globaldisease, COVID- 19. New information about mitochondrial biology is presented, such as theeffect of aerobic physical exercise as a stimulator for mitochondriamultiplication, and the role of mitochondrial damage in inducing immune-inflammatoryresponses to pathogens.
The contents shed light on mitochondrial biochemicalpathways that could serve as potential therapeutic targets. This is an important reference for scholars (cell biologists,microbiologists) in universities, hospitals and scientific research centersworking on biological and biomedical problems, and for health professionalsinvolved in infection control.
Table of Contents
Chapter 1 an Auspicious Bacterium: How Mitochondria Can be Beneficial to the Innate Immunity Through Aerobic Exercises1. Mitochondrial Biogenesis
2. Mitochondria - a Multifunctional Organelle: from the Correlation of Dna Mitochondrial with Inflammatory Diseases and Innate Immune Response
3. Mitochondria Can be Involved in the Pathogenesis of Some Viral Diseases
4. Mitochondria and Aerobic Exercise: New Frontiers in Health Promotion
5. the Tight Link Between Pgc -1, Pparγ, Mitochondrial Dna and the Immuno-Inflammatory Response
6. Final Considerations and Perspectives
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
1. Leprosy-An Overview
2. Clinical Forms of Leprosy
3. Treatment for Leprosy
3.1. Treatment for Reactions in Leprosy
4. Outline of Some Inflammatory Cytokines in Leprosy Reactional Episodes
5. Tnf- and Leprosy Neuritis
6. Mitochondria, Mitochondrial Dna and Leprosy
7. Leprosy - Special Remarks
8. Final Considerations and Perspectives
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
1. Tuberculosis-An Overview
2. Status of the Tb Epidemic
3. Tuberculosis-Disease, Diagnosis, Vaccine and Treatment
4. Latent Tuberculosis
5. the Relevance of Macrophages on Tb Pathogenesis
6. Host Cell Death During M. Tuberculosis Infection - the Active Role of Mitochondria
7. Final Considerations and Perspectives
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
1. Introduction
2. Pneumococcal Pathogenesis: Virulence Factors, Inflammation and Mitochondrial Dna Leakage
3. Mitochondrial Dna and S. Pneumoniae
4. Final Considerations and Perspectives for Therapeutic Interventions
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Fabiana Rabe Carvalho, Débora Familiar-Macedo and Andrea Alice Silva 1. Introducing Zika Virus (Zikv)
3. Mitochondria Fragmentation
4. Mitochondrial Dna and the Immuno-Inflammatory Response in Zikv
5. Final Considerations and Perspectives
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
1. Introducing Coronavirus Infectious Disease 2019 (COVID-19)
2. the Immunopathogenesis of COVID-19
3. Mechanisms Involved in Mitochondrial-Induced Cellular Stress in Sars-Cov-2 Infection
4. Mitochondrial Dysfunction and the Immuno-Inflammatory Response in COVID-19: The Role of Mtdna
4.1. Mtdna
4.2. Mtros
4.3. Mavs
5. Final Considerations and Perspectives
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Subject Index
Author
- Dilvani Oliveira Santos
- Paulo Renato Zuquim Antas
