This book provides a comprehensive overview of the localized drug delivery system landscape. The 10 chapters provide a detailed introduction in polymers, nanostructures and nanocomposites for developing localized controlled drug delivery systems (LCDDSs) in the form of stimuli-responsive delivery systems, targeted drug delivery systems or the combination of both. A discussion on manufacturing techniques, optimization, challenges and adaptation of LCDDSs for the treatment of a wide range of diseases is also included.
This simple and informative resource conveys an understanding about designing novel drug delivery systems to students in advanced pharmacology, biotechnology, materials science and biochemistry study programs. Readers will be equipped with the knowledge of regulating drug release rates to get a desired pharmacological profile that helps a researcher to ensure a high therapeutic effectiveness. The detailed information about various drug delivery systems and a compilation of recent literature sources also paves the way for research scholars to construct a drug targeting framework for their research plans.
Nanotechnology has revolutionized many fields and applications, such as medical diagnosis and treatment, water purification, and environmental protection. There is an art behind the synthesis of nanomaterials and their use in our daily lives. The Art of Nanomaterials takes the reader on a fascinating historical journey to learn how artistic inventiveness has influenced scientific innovation, from ancient Egyptian paintings to modern uses in healthcare and engineering.
This simple and informative resource conveys an understanding about designing novel drug delivery systems to students in advanced pharmacology, biotechnology, materials science and biochemistry study programs. Readers will be equipped with the knowledge of regulating drug release rates to get a desired pharmacological profile that helps a researcher to ensure a high therapeutic effectiveness. The detailed information about various drug delivery systems and a compilation of recent literature sources also paves the way for research scholars to construct a drug targeting framework for their research plans.
Nanotechnology has revolutionized many fields and applications, such as medical diagnosis and treatment, water purification, and environmental protection. There is an art behind the synthesis of nanomaterials and their use in our daily lives. The Art of Nanomaterials takes the reader on a fascinating historical journey to learn how artistic inventiveness has influenced scientific innovation, from ancient Egyptian paintings to modern uses in healthcare and engineering.
Table of Contents
- Preface
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- Systems (Lcddss)
1.2. Scientific and Technological Impact of Lcdds
1.3. Challenges in Localized Stimuli Responsive Materials
- Conclusion
- References
- Delivery Systems (Lcddss)
2.2. Graphene
2.3. Graphene Oxide (Go)
2.4. Reduced Graphene Oxide (Rgo)
2.5. Endogenous Stimuli-Responsive Localized Drug Delivery With
- Graphene
2.5.2. Redox-Responsive Localized Drug Delivery With Graphene
2.6. Graphene-Based Drug Delivery Systems Responsive to External
- Physical Stimuli
2.6.2. Temperature-Responsive Drug Delivery Systems With Graphene
2.7. Toxicity and Biocompatibility of Graphene Materials
2.8. Carbon Nanotube (Cnt)
2.8.1. Multi-Wall Carbon Nanotube (Mwcnt)
2.8.2. Single Wall Carbon Nanotube (Swcnt)
2.9. Fullerene
2.10. Other Carbon Nanostructures:
2.11. Black Phosphorus (Bp)
- Conclusion
- References
(Lcddss)
3.1. Introduction
3.2. Synthetic Polymers
3.2.1. Polyesters
3.2.1.1. Polylactic Acid (Pla) and Polyglycolic Acid (Pga)
3.2.1.2. Poly Lactic-Co-Glycolic Acid (Plga)
3.2.1.3. Polycaprolactones (Pcl)
3.2.1.4. Poly(Alkyl Cyanoacrylates) (Paca)
3.2.3. Poly(Ortho Esters)
3.2.4. Poly(Anhydrides)
3.2.5. Poly(Amides)
3.2.6. Poly(Ester Amides)
3.2.7. Poly(Phosphoesters)
3.3. Naturally-Derived Polymers
3.3.1. Polysaccharides-Based Polymers
3.3.1.1. Chitosan
3.3.1.2. Hyaluronic Acid-Based Polymers
3.3.2. Polypeptides-Based Polymers
3.3.2.1. Collagen-Based Polymers & Gelatin-Based Polymers
- Conclusion
- References
- Characteristics in Localized Controlled Drug Delivery System
4.1. Introduction
4.2. Microstructures
4.3. Glass Transition of Polymer Matrix
4.4. Hydrophobicity and Hydrophilicity of Composites
4.5. Molecular Weight of Polymer Matrix
- Conclusion
- References
5.1. Introduction
5.2. Microscaled Composites in Dds
5.3. Nanoscaled Composites in Dds
5.4. The Epr Effect
5.5. Fabrication Methods of Micro/Nanoscaled Composites
5.5.1. Emulsification-Solvent Evaporation
5.5.2. Spray Drying
5.5.3. Electrospraying
5.5.4. Supercritical Fluids Processing (Scf)
5.5.4.1. The Supercritical Anti-Solvent (Sas) Technique
5.5.4.2. Supercritical Co2 Foaming (Sf)
5.5.5. Microfluidics
5.5.6. Prolease Technique
5.5.7. Nanoprecipitation/Solvent Displacement
5.5.8. Emulsion Techniques
- Conclusion
- References
6.1. Introduction
6.2. Thermo-Responsive Drug Release
6.2.1. Poly(N-Isopropylacrylamide) Vs Poly(Nvinylcaprolactam)-Based Composites
6.2.2. Oligoethylene Glycol-Based Composites
6.2.3. Degradable Composites
6.3. Light-Responsive Drug Delivery
6.3.1. Uv-Light-Responsive Drug Delivery
6.3.2. Nir-Light-Responsive Drug Delivery
6.4. Ultrasound-Responsive Drug Delivery
- Conclusion
- References
7.1. Introduction
7.2. Redox-Sensitive Drug Delivery
7.3. Oxidation-Sensitive Drug Delivery
7.4. Ph-Sensitive Drug Delivery
7.5. Enzyme-Sensitive Drug Delivery
- Conclusion
- References
8.1. Introduction
8.2. Gold Nanoparticles in Triggered Drug Delivery
8.3. Magnetic Nanoparticles in Triggered Drug Delivery
8.4. Calcium Phosphate-Based Nanoparticles in Triggered Drug
- Delivery
- Conclusion
- References
9.1. Introduction
9.2. 3D Printing Methods
9.3 the Role of 3D Printing in Developing and Fabricating Ddss
9.4. From 3D Printing to 4D Printing
9.5. Designing in 4D Printing
- Conclusion
- References
- References
- Subject Index
Contributors
- Seyed Morteza Naghib
- Samin Hoseinpour
- Shadi Zarshad
