Pathology of Laboratory Swine is a comprehensive text describing the spontaneous pathology seen in common laboratory pig strains. As the first book collating information on all organ systems in these strains, this resource will serve as a "go to� text for all pathologists working on laboratory pigs in safety assessment studies and for veterinary pathologists who need a diagnostic tool to rule out spontaneous, non-clinical disease pathology when assigning cause of death to these animals which are also kept as domestic pets.
Table of Contents
1. Choice of Pig model 2. Regulatory issues in the use of minipigs 3. Infectious Diseases 4. Clinical Examination 5. Digestive System (Oral Cavity, Salivary glands, Esophagus and Stomach, Small and Large Intestine 6. Liver 7. Exocrine Pancreas 8. Urinary System (Kidney, Urinary bladder, ureter, urethra 9. Nervous System 10. Eye and associated glands 11. Skeletal Muscle 12. Bone and Joints 13. Skin and subcutis (including specialized sebaceous glands) 14. Mammary Gland 15. Respiratory tract 16. Haemopoietic and Lymphoid System 17. Female Reproductive Tract 18. Male� Reproductive Tract 19. Cardiovascular System 20. Endocrine System (Thyroid, Parathyroid, Pituitary, Adrenal and Endocrine Pancreas 21. Clinical Pathology (Hematology and Clinical Chemistry) 22. Juvenile 23. Immunohistochemistry
Authors
Kris Helke Professor and Chair, Department of Comparative Medicine, Medical University of South Carolina, USA.
Kristi Helke received her DVM in 2000 from the University of Wisconsin- Madison and completed a Fellowship from 2001-2005 in Veterinary Comparative Pathology at the Johns Hopkins University School of Medicine. She also obtained a Ph.D. in 2007 from Johns Hopkins University School of Medicine. Her pathology residency was also completed at Johns Hopkins University, and she is a diplomate of the American College of Veterinary Pathologists. Dr. Helke is currently a professor and Chair of the Department of Comparative Medicine at the Medical University of South Carolina. While there, she has completed several studies for biomedical companies in which she evaluated mice, rats, dogs and pigs for toxicologic changes to novel therapeutics and adverse reactions to both biomedical materials and devices. She also works closely with researchers to develop animal models and pathologic analysis of these models.
Keith Nelson Director, Toxicologic Pathology, Inotiv, Portage, MI, USA.
Keith Nelson has over 15 years experience in toxicologic pathology, working for multiple contract research organizations. He completed his undergraduate and DVM degrees at Michigan State University before spending a year at Oregon State University studying fish immunology and a year in Kenya studying hyena behavior. He then completed his residency and PhD training at Colorado State University, after which he joined MPI Research, intending to "try out� toxicologic pathology. Almost two decades later, he remains excited about the field and has served as a pathologist, leader and mentor at large CROs, and adjunct assistant professor at Michigan State University. He is active within the field of anatomic and toxicologic pathology, holding multiple committee leadership positions in STP and ACVP, serving on the INHAND Minipig committee for harmonization of nomenclature, and publishing and presenting on a wide range of pathology topics.
Aaron M. Sargeant Scientific Director, Pathology, Charles River Laboratories, Spencerville, OH, USA.
Aaron M. Sargeant is a Scientific Director, Pathology at Charles River Laboratories in Spencerville, OH, USA.
Alys Bradley Director of Pathology, Charles River Laboratories, Inc., Wilmington USA.
Dr. Bradley has been with Charles River since 1998 where she is the director of pathology. In this capacity she leads a team of veterinary pathologists and pathology analysts. She has specialist interest and provides consultancy services in neuropathology, non-human primate pathology, medical devices, and cellular therapy products (human and animal stem cells). She is an experienced study pathologist for acute, long term reproductive toxicology, tumorigenicity, oncogenicity, microautoradiography, target animal safety and carcinogenicity studies. She has authored over 700 GLP or GMP compliant toxicological peer reviewed pathology and photomicroscopy reports. She is the GLP and GMP Study Director as well as the Quality Control Manager for GMP pathology services.
