Advances in the treatment of neurodegenerative diseases (NDs) are nominal. Currently available therapies are merely symptomatic treatments that cannot prevent the development of the disease. Several herbs have been found very useful for managing neurological diseases. There are immense possibilities to discover a more successful line of ND treatment. Phytochemicals from medicinal plants may play a vital role in maintaining the chemical balance of the brain by affecting the capacity of receptors for the major inhibitory neurotransmitters. A few plants have already gained popularity for the potential treatment of NDs. This volume highlights the therapeutic role of medicinal plants and their scientific validation for improving neuronal health. It presents 15 chapters that cover the herbal treatment of NDs, including Parkinson’s disease and Alzheimer’s disease. The contents cover a range of pharmaceutical agents like sirtuins, berberine, rosmarinic acid and resveratrol. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.
Table of Contents
Chapter 1 Parkinson's Disease: a Phytotherapeutic Prospective- Introduction
- Neuroprotective Activity of Bioactive Phytocompounds from Medicinal Plants
- M. Pruriens (Kauncha)
- Plant Description
- Phytoconstituents of M. Pruriens
- Neuroprotective Activity of M. Pruriens in Parkinson’S Pathology
- Curcuma Longa (Turmeric)
- Plant Description
- Phytoconstituents of Turmeric
- Neuroprotective Activity of Curcumin in Parkinson’S Pathology
- Zingiber Officinale (Ginger)
- Plant Description
- Phytoconstituents of Ginger
- Neuroprotective Activity of Ginger in Parkinson’S Pathology
- Bacopa Monnieri (Brahmi)
- Phytoconstituents of “Brahmi”
- Neuroprotective Activity of “Brahmi” in Parkinson’S Pathology
- Nardostachys Jatamansi (Jatamansi)
- Plant Description
- Phytoconstituents of “Jatamansi”
- Neuroprotective Activity of N. Jatamansi in Parkinson’S Pathology
- W. Somnifera (Ashwagandha)
- Plant Description
- Phytoconstituents of Ashwagandha
- Neuroprotective Activity of Ashwagandha in Parkinson’S Pathology
- Silybum Marianum (Silymarin)
- Plant Description
- Phytoconstituets of Silymarin
- Neuroprotective Activity of Silymarin in Parkinson’S Pathology
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Vinod Tiwari, Ankit Uniyal, Vineeta Tiwari, Vaibhav Thakur, Mousmi Rani and Akhilesh Introduction
- Neuroinflammation: a Friend or a Foe?
- Neuroinflammation: a Critical Mediator for Neurodegenerative Diseases
- Parkinson’S Disease
- Alzheimer’S Disease
- Multiple Sclerosis
- Huntington’S Disease
- Amyotrophic Lateral Sclerosis
- Therapeutic Pathways for the Near Future Management of Neurodegeneration
- Microglial Responsiveness Modulation: a Potential Tool for Neuroprotection
- Peroxisome Proliferator-Activated Receptor Gamma (Pparγ): a Potential Target Against Neuroinflammation
- P2X7 Purinergic Receptor-Mediated Signalling and Neurodegeneration
- Nf-Κb Signaling and Neuroinflammation
- Toll-Like Receptors: the Biological Switches for Neuroinflammation
- Nlrp3 Inflammasome and Caspase-1 Signalling in Neurodegeneration
- Neuroinflammation-Associated Oxidative Stress Multimodal Cascade
- Neuroinflammation and Mitochondrial Dysfunction
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Sudhir Kumar Shekhar, Sarfraj Ahmad Siddiqui and Girish Rai Introduction
- Sirtuins Structure and Types
- Sirt1
- Sirt2
- Sirt3
- Sirt4
- Sirt5
- Sirt6
- Sirt7
- Sirtuins in Different Brain Functions
- Sirtuins and Neurodegenerative Disorders
- Multiple Sclerosis (Ms)
- Ad
- Pd
- Als
- Wd
- Spinal Cord Injury (Sci)
- Traumatic Brain Injury (Tbi)
- Stroke
- Modulation of Sirtuins
- Stacs
- Nbms
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Ashish Verma, Nilesh Rai, Swapnil C. Kamble, Pradeep Mishra, Suvakanta Barik Rajiv Kumar, Santosh Kumar Singh, Prafull Salvi and Vibhav Gautam Introduction
- Fungal Endophyte as a Source of Bioactive Compound for Managing Health Disorders
- Role of Fungal Endophyte-Derived Bioactive Compounds in Treating Neurodegenerative Diseases
- Fungal Endophyte-Derived Bioactive Compounds Having Anti-Neuroinflammatory Properties
- Fungal Endophyte-Derived Bioactive Compounds in Managing Neuro-Hydrolases
- Role of Fungal Endophyte-Derived Bioactive Compounds in Managing Oxidative Stress Response
- Role of Fungal Endophyte-Derived Bioactive Compounds in the Management of Depression 92 Challenges in the Application of Bioactive Compounds for the Management of Neurodegenerative Disorders
- Conclusion and Future Perspective
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Bedanta Bhattacharjee, Bhargab Deka, Naveen Shivavedi, Hans Raj Bhat, Saurabh Kumar Sinha, Surajit Kumar Ghosh and Anshul Shakya Introduction
- Neuroprotective Herbs
- Allium Sativum
- Camella Sinensis
- Centella Asiatica
- Coriandrum Sativum
- Crocus Sativus
- Glycyrrhiza Glabra
- Morus Alba
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Anuradha Sharma1 and Gurcharan Kaur Introduction
- Brain Health and Neurologic Disease Burden
- Immunomodulatory Role of T. Cordifolia
- Role of T. Cordifolia in Neurodegeneration
- T. Cordifolia and Oxidative Stress
- T. Cordifolia and Neuroinflammation
- Glutamate-Induced Excitotoxicity
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Mamta Tiwari and Anurag Pandey Introduction
- Pathology of Pd
- Signs and Symptoms of Pd
- Aetiology of Pd
- Ayurvedic Understanding of Pd
- Aetiology of Pd as Per Ayurveda
- M. Pruriens in Ayurveda
- Properties of M. Pruriens
- M. Pruriens as Source of L-Dopa
- Neuroprotective Activity of M. Pruriens
- Hypoglycaemic Activity of M. Pruriens
- Anti-Inflammatory Activity of M. Pruriens
- Anti-Depressant Activity of M. Pruriens
- Antioxidant Activity of M. Pruriens
- Discussion
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgement
- References
- Prachi Pattnaik, Chetan Panda, Tarun Minocha, Sanjeev Kumar Yadav, Namrata Dwivedi and Sandeep Kumar Singh Introduction
- What Are Neurodegenerative Diseases?
- Phytodrugs - the Potential Alternative
- Perks of Phytomedicines Over Synthetic Drugs
- What Are Nootropics?
- Role of Phytomedicines in Neuroprotection
- Bacopa Monnieri: a Real Fortune for Neural Health
- Taxonomic Classification
- Botany
- Pharmaceutical Properties and Uses
- Neuroprotective Aspect of Brahmi
- Role of Bm in Curing Ad
- Effect on Curing Cancer
Author
- Surya Pratap Singh
-Hareram Birla
