The foundational textbook on the study of virology
Basic Virology, 4th Edition cements this series’ position as the leading introductory virology textbook in the world. It’s easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.
This undergraduate-accessible book covers all the foundational topics in virology, including:
- The basics of virology
- Virological techniques
- Molecular biology
- Pathogenesis of human viral disease
The 4th edition includes new information on the SARS, MERS and COVID-19 coronaviruses, hepatitis C virus, influenza virus, as well as HIV and Ebola. New virological techniques including bioinformatics and advances in viral therapies for human disease are also explored in-depth. The book also includes entirely new sections on metapneumoviruses, dengue virus, and the chikungunya virus.
Table of Contents
Preface xxi
Acknowledgements xxvii
Part I Virology and Viral Disease 1
Chapter 1 Introduction - The Impact of Viruses on Our View of Life 3
Chapter 2 An Outline of Virus Replication and Viral Pathogenesis 15
Chapter 3 Virus Disease in Populations and Individual Animals 27
Chapter 4 Patterns of Some Viral Diseases of Humans 43
Part II Basic Properties of Viruses and Virus-cell Interaction 65
Chapter 5 Virus Structure and Classification 67
Chapter 6 The Beginning and End of the Virus Replication Cycle 85
Chapter 7 The Innate Immune Response: Early Defense Against Pathogens 105
Chapter 8 Strategies to Protect Against and Combat Viral Infection 131
Part III Working with Virus 153
Chapter 9 Visualization and Enumeration of Virus Particles 155
Chapter 10 Replicating and Measuring Biological Activity of Viruses 163
Chapter 11 Physical and Chemical Manipulation of the Structural Components of Viruses 181
Chapter 12 Characterization of Viral Products Expressed in the Infected Cell 197
Chapter 13 Viruses Use Cellular Processes to Express their Genetic Information 217
Part IV Replication Patterns of Specific Viruses 245
Chapter 14 Replication of Positive‐Sense RNA Viruses 247
Chapter 15 Replication Strategies of RNA Viruses Requiring RNA‐directed mRNA Transcription as the First Step in Viral Gene Expression 277
Chapter 16 Replication Strategies of Small and Medium‐sized DNA Viruses 307
Chapter 17 Replication of Some Nuclear‐replicating Eukaryotic DNA Viruses with Large Genomes 335
Chapter 18 Replication of Cytoplasmic DNA Viruses and “Large” Bacteriophages 363
Chapter 19 Retroviruses: Converting RNA to DNA 385
Chapter 20 Human Immunodeficiency Virus Type 1 (HIV‐1) and Related Lentiviruses 403
Chapter 21 Hepadnaviruses: Variations on the Retrovirus Theme 415
Part V Molecular Genetics of Viruses 437
Chapter 22 The Molecular Genetics of Viruses 439
Chapter 23 Molecular Pathogenesis 467
Chapter 24 Viral Bioinformatics 477
Chapter 25 Viruses and the Future - Problems and Promises 489
Appendix - Resource Center 503
Technical Glossary 509
Index 533
