Sustainable and Green Approaches in Medicinal Chemistry: Applications, Second Edition reveals essential context on the growth of green chemistry in relation to drug discovery, identifying a broad range of practical techniques and useful insights and revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure, and increase the environmental benignity of the entire drug discovery process. The book encourages the growth of green medicinal chemistry and supports medicinal chemists, drug discovery researchers, pharmacologists, and all those in related fields across both academia and industry in integrating these approaches into their own work. This volume includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods.
Table of Contents
Chemical Catalysis1. Green Metal-Catalyzed Reactions Under Sustainable Conditions Towards Medicinally Potent Biomolecules
2. Graphene Oxide and Modified Graphene Oxide-Mediated Synthesis of Medicinally Active Compounds
3. Organocatalytic Cycloaddition Reaction: A Gateway for Molecular Complexity
Biocatalysis
4. Baker's Yeast-Induced Synthesis of Medicinally Important Compounds
5. New Methods for the Manufacturing of Pharmaceuticals and Their Intermediates Using Lipase
Green Solvents
6. Green Synthesis of Biologically Active Pyrroles and Related Substrates via C-H Bond Functionalization
7. Ionic Liquids in Pharmaceutics and Bioanalytics
8. Synthesis of Bioactive Heterocyclic Compounds Using Green Solvents
9. Reactions in Water: Synthesis of Biologically Active Compounds
Green Chemistry
10. Sustainable Green Technologies for Synthesis of Potential Drugs Targeted towards Tropical Diseases
11. Clay-Mediated Synthesis of Biologically Active Molecules: Green and Sustainable Approaches
12. The Role of Ionic Liquid in Medicinal Chemistry
Medicinal Chemistry
13. Green Chemistry for the Synthesis of Sulfur containing Compounds with Medicinal Properties
14. Sustainable green approaches for synthesis of bio-active flavonoids as cardio-protective and anticancer drug agents
15. Polysaccharide-derived hydrogels: An approach towards cancer
16. Environmental Benign Pathways for the Synthesis of Medicinally Relevant Heterocycles
17. Utilization of medicinally important plants as antidiabetic medicines in a sustainable manner
18. One-Pot Synthesis of Biologically Active Oxazole, Iso-oxazole, and Pyranopyazoles-An Overview
19. Green synthesis of Organometallic Compounds and their Medicinal aspects
20. Biologically active macrocycles in medicine
21. Green Synthesis and Biological Evaluation of Anticancer Drugs
22. Green Chemistry and Synthetic Approaches in the Development of Antidepressant and Antipsychotic agents
23. Organocatalyzed multi-component synthesis of densely functionalized bioactive pyridine derivatives
24. Multicomponent reaction strategy to heterocyclic compounds in anticancer drug design
25. Recent Advances in Asymmetric Synthesis of �-Lactams
Authors
Bimal Krishna Banik Vice President of Research and Education Development, Community Health Systems of South Texas, USA. Since being awarded his PhD by the Indian Association for the Cultivation of Science, Calcutta, Professor Banik has held positions as a Postdoctoral Fellow at Case Western Reserve University and Stevens Institute of Technology; Tenured Full Professor in Chemistry and First President's Endowed Professor in Science & Engineering at the University of Texas-Pan American, Edinburg; an Assistant Professor in Molecular Pathology at the University of Texas M. D. Anderson Cancer Center, Houston; and a Research Assistant Professor in Chemistry & Chemical Biology at Stevens Institute of Technology, New Jersey. Since 2014, he has been the Vice President of Research & Education Development of Community Health Systems of South Texas.Professor Banik has designed, synthesized, and identified novel beta lactams derived from polyaromatic compounds as anticancer agents. He is involved in the asymmetric synthesis, biological evaluation, delivery of compounds to increase the effectiveness and mechanism of actions studies of beta lactams and polyaromatic compounds as anticancer agents.
As the Principal Investigator, Professor Banik has been awarded $7.25 million in grants from the US National Institutes of Health, US National Cancer Institute, and Kleberg Foundation. He has also has more than 315 publications to his name (including peer-reviewed papers and patents, book chapters, books, perspectives, commentaries and reviews) along with approximately 460 presentation abstracts with 6000 citations. He is a reviewer of 93, editorial board member of 28, editor-in-chief of 9, founder of 4, associate editor of 4 and guest editor of 6 research journals. Furthermore, Professor Banik has presided over numerous research sessions at top conferences in the field, including one at the Nobel Prize celebration in Germany.
