Synthesis of Aziridines and Oxaziridines from Imines describes both new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine.
The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures.
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Table of Contents
1. Aziridine synthesis from imines-I
2. Aziridine synthesis from imines-II
3. Aziridine synthesis by condensation of phenylimines with ethyl diazoacetate
4. Aziridine synthesis by metal-catalyzed condensation of phenylimines with ethyl diazoacetate
5. Aziridine synthesis by addition of biphenyl imines to ethyl diazoacetate
6. Aziridine synthesis by metal-catalyzed addition of biphenyl imines to ethyl diazoacetate
7. Aziridine synthesis by condensation of imines with diazo compounds
8. Aziridine synthesis by condensation of imines with diazomethane
9. Aziridine synthesis by ring-closure of haloimines
10. Aziridine synthesis by ring-closure of imines and halo compounds
11. Aziridine synthesis by alkene-imine and alkyne-imine reactions
12. Oxaziridine synthesis from imines
13. Oxaziridine synthesis from imines using m-CPBA
Authors
Navjeet Kaur Lovely Professional University, India.Dr. Navjeet Kaur, Ph.D. (Chemistry, Banasthali Vidyapith, 2014) is currently an Associate Professor in the Department of Chemistry and Division of Research & Development at Lovely Professional University, Punjab. She specializes in organic synthetic and medicinal chemistry, with a focus on heterocyclic compound synthesis. With 14 years of teaching and research experience, she has guided five Ph.D. scholars and numerous MSc students, and has published over 200 research papers, reviews, books, and chapters. She is the author of nineteen books with leading publishers including CRC Press, Elsevier, and Springer Nature.
Dr. Kaur has consistently ranked among the World's Top 2% Scientists in subject-wise analyses by Stanford University (2018-2025). She has received awards such as the Prof. G. L. Telesara Award and Best Paper Presentation Award, and has served as Editor-in-Chief of Advanced Chemicobiology Research. Beyond academia, she has contributed to rural development initiatives through NSS and UBA, and holds a Sikh Missionary certification.
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