Seldin and Giebisch's The Kidney, Sixth Edition: Physiology and Pathophysiology provides a common language for nephrology researchers, fellows and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of normal renal physiology, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation.This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise and readily accessible information. Academic, medical and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.
Table of Contents
Volume 1I: Epithelial and Nonepithelial Transport and Regulation
1. Epithelial Cell Structure and Polarity
2. Mechanisms of Ion Transport across Cell Membranes
3. Renal Ion-Translocating ATPases
4. Mechanisms of Water Transport Across Cell Membranes and Epithelia
5. Cell Volume Control
6. Solute Transport, Energy Consumption, and Production in the Kidney
7. Electrophysiological Analysis of Transepithelial Transport
8. Renal Ion Channels, Electrophysiology of Transport, and Channelopathies
9. Microvascular Permeability and the Exchange of Water and Solutes Across Microvascular Walls
10. External Balance of Electrolytes and Acids and Alkali
11. Renal Cilia Structure, Function, and Physiology
12. Intercellular Junctions
13. Principles of Cell Signaling
14. Scaffolding Proteins in Transport Regulation
15. The Renin-Angiotensin System
16. Neural Control of Renal Function
17. Eicosanoids and Renal Function
18. Extracellular Nucleotides and Renal Function
19. Paracrine Regulation of Renal Function by Dopamine
II: Structural and Functional Organization of the Kidney
20. Structural Organization of the Mammalian Kidney
21. Biophysical Basis of Glomerular Filtration
22. Glomerular Cell Biology
23. Function of the Juxtaglomerular Apparatus: Control of Glomerular Hemodynamics and Renin Secretion
24. Renal Cortical and Medullary Microcirculations: Structure and Function
25. Molecular and Cellular Mechanisms of Kidney Development
26. Molecular and Cellular Mechanisms of Glomerular Capillary Development
27. Postnatal Renal Development
28. Renal Hyperplasia and Hypertrophy
29. Stem Cells and Generation of New Cells in the Adult Kidney
III: Fluid and Electrolyte Regulation and Dysregulation
30. Epithelial Na+ Channels
31. Anion Channels
32. Physiology and Pathophysiology of the NaCl Co-Transporters in the Kidney
33. Sodium and Chloride Transport: Proximal Nephron
34. Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct
35. Mineralocorticoid Action in the Aldosterone Sensitive Distal Nephron
36. Inherited Disorders of Renal Salt Homeostasis: Insights from Molecular Genetics Studies
37. Natriuretic Hormones
38. Pathophysiology of Sodium Retention and Wastage
39. Physiology and Pathophysiology of Hypertension
40. Physiology and Pathophysiology of Diuretic Action
41. Aquaporin Water Channels in Mammalian Kidney
42. Thirst and Vasopressin
43. The Urine Concentrating Mechanism and Urea Transporters
44. Hyponatremia
45. Hypernatremic States
46. Polyuria and Diabetes Insipidus
47. The Molecular Biology of Renal K+ Channels
48. Extrarenal Potassium Metabolism
49. Regulation of K+ Excretion
50. Physiopathology of Potassium Deficiency
Volume II
51. Clinical Disorders of Hyperkalemia
52. Control of Intracellular pH
53. SLC4 Sodium-Driven Bicarbonate Transporters
54. The SLC4 Anion Exchanger Gene Family
55. Cellular Mechanisms of Renal Tubular Acidification
56. Chemoreceptors, Breathing and pH
57. Renal Ammonium Ion Production and Excretion
58. Clinical Syndromes of Metabolic Alkalosis
59. Clinical Syndromes of Metabolic Acidosis
60. Respiratory Acid-Base Disorders
61. Mechanisms and Disorders of Magnesium Metabolism
62. Calcium Channels
63. The Calcium-Sensing Receptor
64. Renal Calcium Metabolism
65. The Hormonal Regulation of Calcium Metabolism
66. Disorders of Calcium Metabolism
67. Pathogenesis and Treatment of Nephrolithiasis
68. Proximal Tubular Handling of Phosphate
69. Clinical Disturbances of Phosphate Homeostasis
70. Glucose Reabsorption in The Kidney
71. Kidney Transport of Amino Acids and Oligopeptides, and Aminoacidurias
72. Organic Anion and Cation Transporters in Renal Elimination of Drugs
73. Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria
IV: Pathophysiology of Renal Disease
74. Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid-Base Disorders
75. Biomarkers for Assessment of Renal Function During Acute Kidney Injury
76. Pathophysiology of Acute Kidney Injury
77. Ischemic Renal Disease
78. Pathophysiology and Pathogenesis of Diabetic Nephropathy
79. Renal Failure in Cirrhosis
80. Autosomal Dominant Polycystic Kidney Disease
81. Renal Physiology and Disease in Pregnancy
82. Immune and Inflammatory Glomerular Diseases
83. Immunologic Mechanisms of Vasculitis
84. Genetic Abnormalities in Glomerular Function
85. Cellular Mechanisms of Drug Nephrotoxicity
86. Role of Glomerular Mechanical Stress in the Pathogenesis of Chronic Kidney Disease
87. Role of Proteinuria in the Progression of Renal Disease
88. The Inflammatory Response to Ischemic Acute Renal Injury
89. Catalytic (Labile) Iron in Kidney Disease
90. Chronic Kidney Disease: Pathophysiology and the Influence of Dietary Protein
91. Management of Calcium and Bone Disease in Renal Patients
92. Hematopoiesis and the Kidney
93. Individualizing the Dialysate to Address Electrolyte Disturbances in the Dialysis Patient
94. Homeostasis of Solute and Water by the Transplanted Kidney
95. Renal Disposition of Drugs and Translation to Dosing Strategies
Authors
Robert J. Alpern Dean and Ensign Professor of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. Dr. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in Internal Medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the medical school. He is now Dean of Yale School of Medicine and Ensign Professor. Michael J. Caplan C.N.H. Long Professor and Chair, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA. Dr. Caplan studies epithelial cell biology and physiology. His work focuses on the trafficking and regulation of renal ion transport proteins. His group also studies the signaling pathways involved in Autosomal Dominant Polycystic Kidney Disease. He received his MD and PhD degrees from Yale University, having pursued his dissertation work in the Department of Cell Biology under the guidance of Drs. James D. Jamieson and George E. Palade. Following postdoctoral work in the Department of Cellular and Molecular Physiology at Yale, Caplan joined that department as a faculty member. He is currently the C.N.H. Long Professor and Chair of Yale University School of Medicine's Department of Cellular and Molecular Physiology. Orson W. Moe Professor of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Dr. Moe received his medical degree from the University of Toronto where he also did his internal medicine residency and clinical nephrology fellowship. Orson Moe moved to the University of Texas Southwestern Medical Center for research training in renal physiology. He is currently Professor of Internal Medicine and Physiology and is a member of the Nephrology Division at the University of Texas Southwestern Medical Center in Dallas. He is also the Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and holds the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. Orson Moe conducts both basic science and patient-oriented research on renal physiology and metabolism, and epithelial biology. Susan E. Quaggin Director, Feinberg Cardiovascular Research Institute, Chicago; Chief, Division of Medicine-Nephrology, Professor in Medicine-Nephrology, Northwestern University, Evanston, IL, USA. Susan E. Quaggin, MD, FASN, is a graduate of the University of Toronto where she completed her residency and served as chief medical resident for the University's St. Michael's Hospital. She completed her nephrology fellowship at the University of Toronto and Yale University, where she also completed research and post-doctoral training. Dr. Quaggin also trained in the developmental biology program at the University of Toronto's Samuel Lunenfeld Research Institute.Dr. Quaggin also now serves as Editor for Current Opinion in Nephrology & Hypertension and The Kidney, and as an Editorial Board Member for JCI, Disease Models and Mechanisms, and Kidney International.
Currently the Charles Horace Mayo professor of medicine at Northwestern University and a Finnish Distinguished Professor (2012-2017), Dr. Quaggin's awards and honors include the International Society of Nephrology (ISN) Alfred Newton Richards Award for Basic Science, (2013); a Kidney Foundation of Canada Medal for Research Excellence, (2009); American Heart Association, Hypertension Council Donald Seldin Lecture and Award, (2012); Princesses' Lectureship at the Victor Chang Cardiovascular Research Institute, (2013); a W. Berliner Lectureship at Yale University, (2015); a Ruth Abrahmson Visiting Lectureship, (2015); a Josh Thurman Visiting Lectureship, (2015); an Andreoli Lectureship, (2015); a Phillip A. Liverman Distinguished Lectureship, (2014); a Tisher Visiting Professor of Nephrology, (2012), a Mitch Lectureship (2016), the Shaul-Massry Visiting Professor (2017); a Gabor-Zellerman Endowed Professorship in Renal Medicine, (2009-2012); the University of Toronto's Department of Medicine Research Award, (2009) and William Goldie Prize in Internal Medicine, (2005); The Lloyd S.D. Fogler QC Award of Excellence, at Mount Sinai Hospital, (2004); Premier's Research Excellence Award (PREA), (2003); and The Joe Doupe Canadian Society of Clinical Investigation Young Investigator Award, (2003). She served as Canada Research Chair in Vascular Biology from 2005 to 2010. She was elected to the American Society for Clinical Investigation in 2006 and the Association of American Physicians in 2013.
