Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, Sixth Edition provides a common language for nephrology researchers, fellows, and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of the normal kidney, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation. This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise, and readily accessible information. Academic, medical, and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.
Table of Contents
Volume 1Section I: Epithelial and nonepithelial transport and regulation
1. Epithelial cell structure and polarity
2. Mechanisms of ion and water transport across cell membranes and epithelia
3. Renal ion-translocating ATPases
4. Cell volume control
5. Solute transport, energy consumption and production in the kidney
6. Electrophysiological analysis of transepithelial transport
7. Renal ion channels, electrophysiology of transport and channelopathies
8. Microvascular permeability and the exchange of water and solutes across microvascular walls
9. Renal cilia structure, function, and physiology
10. Intercellular junctions and cell-matrix interactions
11. Principles of cell signaling
12. Scaffolding proteins in transport regulation
13. The renin-angiotensin system
14. Neural control of renal function
15. Eicosanoids and renal function
16. Extracellular nucleotides, metabolites, and renal function
Section II: Structural and functional organization of the kidney
17. Structural organization of the mammalian kidney
18. Biophysical basis of glomerular filtration
19. Glomerular cell biology
20. Function of the juxtaglomerular apparatus: control of glomerular hemodynamics and renin secretion
21. Vasculature of the kidney cortex and medulla
22. The development of the kidney
23. Molecular and cellular mechanisms of glomerular capillary development
Section III: Fluid and electrolyte regulation and dysregulation
24. Epithelial Na + channels
25. Anion channels
26. Physiology and pathophysiology of the NaCl cotransporters in the kidney
27. Balance and the pathophysiology of acid-base, fluid, and electrolyte disorders
28. Sodium and chloride transport in the proximal tubule
29. Mineralocorticoid action in the aldosterone-sensitive distal nephron
30. Genetic disorders of renal salt homeostasis and blood pressure
31. Pathophysiology of sodium retention and wastage
32. Physiology and pathophysiology of hypertension
33. Aquaporin water channels in mammalian kidney
34. Thirst and vasopressin
35. The urine-concentrating mechanism and urea transporters
36. Hyponatremia
37. Hypernatremic states
38. The function and regulation of renal K + channels
39. Extrarenal potassium metabolism
40. Regulation of K? excretion
41. Physiopathology of potassium deficiency
42. Clinical disorders of hyperkalemia
Volume 2
Section III: Fluid and electrolyte regulation and dysregulation (contd)
43. Intracellular pH homeostasis
44. SLC4 sodium-coupled bicarbonate and carbonate transporters
45. Anion exchangers of the SLC4 gene family
46. Cellular mechanisms of renal tubular acidification
47. Renal ammonium ion production and transport
48. Clinical syndromes of metabolic alkalosis
49. Clinical syndromes of metabolic acidosis
50. Respiratory acid-base disorders
51. Mechanisms and disorders of magnesium metabolism
52. Calcium channels
53. The calcium-sensing receptor
54. Renal calcium metabolism
55. Kidney stones
56. Proximal tubular handling of phosphate
57. Clinical disturbances of phosphate homeostasis
58. Glucose reabsorption in the kidney
59. Kidney transport of amino acids and oligopeptides and aminoacidurias
60. Renal filtration, transport, and metabolism of albumin and albuminuria
Section IV: Pathophysiology of renal disease
61. Physiologic principles in the clinical evaluation of electrolyte, water, and acid-base disorders
62. Acute kidney injury biomarkers
63. Pathophysiology of acute kidney injury
64. Ischemic renal disease
65. Pathophysiology and pathogenesis of diabetic kidney disease
66. Autosomal dominant polycystic kidney disease
67. Renal physiology and disease in pregnancy
68. Glomerular disorders
69. Immunologic mechanisms of vasculitis
70. Genetic abnormalities in glomerular function
71. Mechanisms of drug nephrotoxicity
72. Role of proteinuria in the progression of renal disease
73. Oxidative stress and signaling in renal physiology and kidney diseases
74. Pathogenesis and management of disordered mineral metabolism in patients with chronic kidney disease
75. Individualizing the dialysate to address electrolyte disturbances in the dialysis patient
76. Mechanisms of allograft rejection
77. Homeostasis of solute and water by the transplanted kidney
Authors
Robert J. Alpern Dean and Ensign Professor of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.Dr. Robert J. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in internal medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the Medical School. He then moved to Yale as the Dean of Yale School of Medicine and is now Ensign Professor of Medicine and Cellular and Molecular Physiology at Yale.
Michael J. Caplan C.N.H. Long Professor and Chair, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA. Dr. Michael Caplan studies epithelial cell biology and physiology. His work focuses on the trafficking and regulation of renal ion transport proteins. His group also studies the signaling pathways involved in autosomal dominant polycystic kidney disease. He received his MD and PhD degrees from Yale University, having pursued his dissertation work in the Department of Cell Biology under the guidance of Drs. James D. Jamieson and George E. Palade. He is currently C.N.H. Long Professor and Chair of Yale University School of Medicine's Department of Cellular and Molecular Physiology. Orson W. Moe Professor of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Dr. Orson W. Moe received his MD degree from the University of Toronto, where he also did his internal medicine residency and clinical nephrology fellowship. Dr. Orson Moe moved to the University of Texas Southwestern Medical Center for research training in renal physiology. He is currently Professor of Internal Medicine and Physiology and member of the Nephrology Division at the University of Texas Southwestern Medical Center in Dallas. He is also Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and holds the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. Dr. Moe conducts both basic science and patient-oriented research on renal physiology and metabolism, and epithelial biology. Susan E. Quaggin Director, Feinberg Cardiovascular Research Institute, Chicago; Chief, Division of Medicine-Nephrology, Professor in Medicine-Nephrology, Northwestern University, Evanston, IL, USA.Dr. Susan E. Quaggin, MD, FASN, is a graduate of the University of Toronto, where she completed her residency and served as Chief Medical Resident for the University's St. Michael's Hospital. She completed her nephrology fellowship at the University of Toronto and Yale University, where she also completed research and postdoctoral training. Dr. Quaggin also trained in the developmental biology program at the University of Toronto's Samuel Lunenfeld Research Institute. Dr. Quaggin now serves as Editor for Current Opinion in Nephrology and Hypertension and The Kidney, and as an Editorial Board Member for JCI, Disease Models and Mechanisms, and Kidney International. Currently, Charles Horace Mayo Professor of Medicine at Northwestern University and a Finnish Distinguished Professor (2012-17). Dr. Quaggin has been the recipient of many awards and honors.
