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Essential Biochemistry, International Adaptation. Edition No. 5

  • Book

  • 752 Pages
  • February 2024
  • Region: Global
  • John Wiley and Sons Ltd
  • ID: 5938772

Essential Biochemistry, 5th edition, comprises biology, pre-med, and allied health topics and presents a broad, but not overwhelming, base of biochemical coverage that focuses on the chemistry behind biology. This text relates the chemical concepts that scaffold the biology of biochemistry, providing practical knowledge and many problem-solving opportunities to hone skills. Key Concepts and Concept Check features help students identify and review important takeaways in each section.

This international adaptation contains up-to-date coverage of topics, including Ramachandran diagrams, lysozymes, steroid hormones, and ionophores. It also offers integrated coverage of SARS-CoV-2 and the impacts of COVID-19, relating it to the importance of an interdisciplinary response to a global pandemic. By focusing on strengthening the organization of the content as well as updating the end-of-chapter problems, this edition presents a brand-new experience to the reader.

Table of Contents


1 The Chemical Basis of Life

1.1 What Is Biochemistry?

1.2 The Origin of Cells

1.3 Biological Molecules

1.4 Energy and Metabolism


2 Aqueous Chemistry

2.1 Water Molecules and Hydrogen Bonds

2.2 The Hydrophobic Effect

2.3 Acid-Base Chemistry

2.4 Tools and Techniques: Buffers

2.5 Clinical Connection: Physiological Buffers



3 Nucleic Acid Structure and Function

3.1 Nitrogenous Bases

3.2 Nucleic Acid Structure

3.3 The Central Dogma

3.4 Genomics


4 Amino Acid and Protein Structure

4.1 Amino Acids, the Building Blocks of Proteins

4.2 Secondary Structure: The Conformation of the Peptide Group

4.3 Tertiary Structure and Protein Stability

4.4 Quaternary Structure

4.5 Clinical Connection: Protein Misfolding and Disease

4.6 Tools and Techniques: Analyzing Protein Structure


5 Protein Function

5.1 Myoglobin and Hemoglobin: Oxygen-Binding Proteins

5.2 Clinical Connection: Hemoglobin Variants

5.3 Structural Proteins

5.4 Motor Proteins

5.5 Antibodies


6 Enzymes: Classification and Catalysis

6.1 What Is an Enzyme?

6.2 Chemical Catalytic Mechanisms

6.3 Unique Properties of Enzyme Catalysts

6.4 Chymotrypsin in Context

6.5 Clinical Connection: Blood Coagulation


7 Enzyme Kinetics and Inhibition

7.1 Introduction to Enzyme Kinetics

7.2 The Michaelis-Menten Equation for an Enzyme-Catalyzed Reaction

7.3 Enzyme Inhibition

7.4 Clinical Connection: Drug Development


8 Lipids and Biological Membranes

8.1 Lipids

8.2 The Lipid Bilayer

8.3 Membrane Proteins

8.4 The Fluid Mosaic Model


9 Membrane Transport

9.1 The Thermodynamics of Membrane Transport

9.2 Passive Transport

9.3 Active Transport

9.4 Membrane Fusion

10 Signaling

10.1 General Features of Signaling Pathways

10.2 G Protein Signaling Pathways

10.3 Receptor Tyrosine Kinases

10.4 Lipid Hormone Signaling


11 Carbohydrates

11.1 Monosaccharides

11.2 Disaccharides, Oligosaccharides, and Polysaccharides

11.3 Glycoconjugates: Glycoproteins, Glycolipids, and Proteoglycans

11.4 Clinical Connection: Glucose and Diabetes Mellitus



12 Metabolism and Bioenergetics

12.1 Food and Fuel

12.2 Free Energy Changes in Metabolic Reactions

12.3 Metabolic Pathways


13 Carbohydrate Metabolism

13.1 Glycolysis 

13.2 Gluconeogenesis

13.3 Glycogen Synthesis and Degradation

13.4 The Pentose Phosphate Pathway

13.5 Clinical Connection: Disorders of Carbohydrate Metabolism


14 The Citric Acid Cycle

14.1 The Pyruvate Dehydrogenase Reaction

14.2 The Eight Reactions of the Citric Acid Cycle

14.3 Thermodynamics of the Citric Acid Cycle

14.4 Anabolic and Catabolic Functions of the Citric Acid Cycle


15 Oxidative Phosphorylation

15.1 The Thermodynamics of Oxidation-Reduction Reactions

15.2 Mitochondrial Electron Transport

15.3 ATP Synthase

15.4 Chemiosmosis


16 Photosynthesis

16.1 Photosynthesis: An Overview

16.2 The Light Reactions

16.3 Carbon Fixation


17 Lipid Metabolism

17.1 Lipid Digestion and Transport

17.2 Fatty Acid Oxidation

17.3 Fatty Acid Synthesis

17.4 Synthesis of Other Lipids


18 Nitrogen Metabolism

18.1 Nitrogen Fixation and Assimilation

18.2 Amino Acid Biosynthesis

18.3 Amino Acid Catabolism

18.4 Excretion of Excess Nitrogen: The Urea Cycle

18.5 Nucleotide Metabolism


19 Regulation of Mammalian Fuel Metabolism

19.1 Integration of Fuel Metabolism

19.2 Hormonal Control of Fuel Metabolism

19.3 Disorders of Fuel Metabolism

19.4 Clinical Connection: Cancer Metabolism



20 DNA Replication and Repair

20.1 DNA Packaging: Nucleosome and Chromatin

20.2 The DNA Replication Machinery

20.3 Telomeres

20.4 DNA Damage and Repair

20.5 Clinical Connection: Cancer as a Genetic Disease

20.6 Tools and Techniques: Manipulating DNA



21 Transcription and RNA Processing

21.1 Initiating Transcription

21.2 RNA Polymerase

21.3 RNA Processing


22 Protein Synthesis

22.1 tRNA and the Genetic Code

22.2 Ribosome Structure

22.3 Translation

22.4 Post-Translational Modifications






Charlotte W. Pratt University of Notre Dame; Duke University; University of North Carolina at Chapel Hill; Seattle Pacific University. Kathleen Cornely Ohio State University; Indiana University; Cornell University; Providence College.