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U.S. Next Generation Sequencing Market Size, Share & Trends Analysis Report by Technology, Product, Application, Workflow (Pre-sequencing, Sequencing, Data Analysis), End Use, and Growth Forecasts, 2025-2033

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    Report

  • 150 Pages
  • September 2025
  • Region: United States
  • Grand View Research
  • ID: 5950105
The U.S. next generation sequencing market size was estimated at USD 4.43 Billion in 2025 and is projected to reach USD 16.75 billion by 2033, growing at a CAGR of 18.1% from 2025 to 2033. A robust presence of pharmaceutical, biotech entities, and research institutions drives next-generation sequencing (NGS) technology in the country. The market is propelled by increasing research and development (R&D) programs focusing on cancer, infectious diseases, and precision medicine. Moreover, genetic testing advancements are fueling NGS adoption in clinical labs for diagnosing rare conditions and guiding precision medicine.

Rising Incidence of Cancer and Genetic Disorders

The increasing prevalence of cancer, hereditary diseases, and complex genetic disorders in the U.S. is a significant driver of the NGS market. Next-generation sequencing enables early detection of genetic mutations and chromosomal abnormalities, facilitating timely diagnosis and personalized treatment planning. In oncology, NGS helps identify tumor-specific mutations, stratify patients for targeted therapies, and monitor disease progression or recurrence. It provides comprehensive genomic insights for rare and inherited disorders, supporting accurate diagnosis, carrier screening, and risk assessment for family members. Growing awareness among healthcare providers and patients about the benefits of genetic testing is further fueling adoption.

Moreover, initiatives such as newborn screening programs, prenatal genetic testing, and large-scale population genomics studies are expanding the use of NGS across clinical and research settings. The increasing demand for precision medicine, coupled with rising investment in genetic and genomic research, underscores the critical role of NGS in improving patient outcomes. As the incidence of cancer and genetic disorders continues to increase, the adoption of NGS is expected to grow steadily, solidifying its position as a transformative technology in the U.S. healthcare and life sciences ecosystem.

U.S. Next Generation Sequencing Market Report Segmentation

This report forecasts revenue growth and provides an analysis on the latest trends in each of the sub-segments from 2021 to 2033. For this report, the analyst has segmented the U.S. next generation sequencing market based on technology, product, application, workflow, and end use.

Technology Outlook (Revenue, USD Million, 2021-2033)

  • Whole Genome Sequencing
  • Whole Exome Sequencing
  • Targeted Sequencing & Resequencing
  • Others

Product Outlook (Revenue, USD Million, 2021-2033)

  • Platforms
  • Consumables

Application Outlook (Revenue, USD Million; 2021-2033)

  • Oncology
  • Clinical Investigation
  • Reproductive Health
  • HLA Typing/Immune System Monitoring
  • Metagenomics, Epidemiology & Drug Development
  • Agrigenomics & Forensics
  • Consumer Genomics

Workflow Outlook (Revenue, USD Million, 2021-2033)

  • Pre-Sequencing
  • Sequencing
  • NGS Data Analysis

End Use Outlook (Revenue, USD Million, 2021-2033)

  • Academic Research
  • Clinical Research
  • Hospitals & Clinics
  • Pharma & Biotech Entities
  • Other users

Why should you buy this report?

  • Comprehensive Market Analysis: Gain detailed insights into the market across major regions and segments.
  • Competitive Landscape: Explore the market presence of key players.
  • Future Trends: Discover the pivotal trends and drivers shaping the future of the market.
  • Actionable Recommendations: Utilize insights to uncover new revenue streams and guide strategic business decisions.

This report addresses:

  • Market intelligence to enable effective decision-making
  • Market estimates and forecasts from 2018 to 2030
  • Growth opportunities and trend analyses
  • Segmental and regional revenue forecasts for market assessment
  • Competition strategy and market share analysis
  • Product innovation listings for you to stay ahead of the curve

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Table of Contents

Chapter 1. Methodology and Scope
1.1. Market Segmentation & Scope
1.1.1. Technology
1.1.2. Product
1.1.3. Application
1.1.4. Workflow
1.1.5. End-use
1.1.6. Estimates and forecast timeline
1.2. Research Methodology
1.3. Information Procurement
1.3.1. Purchased database
1.3.2. internal database
1.3.3. Secondary sources
1.3.4. Primary research
1.4. Information or Data Analysis
1.4.1. Data analysis models
1.5. Market Formulation & Validation
1.6. Model Details
1.7. List of Secondary Sources
1.8. List of Primary Sources
1.9. Objectives
Chapter 2. Executive Summary
2.1. Market Outlook
2.2. Segment Snapshot
2.3. Competitive Insights
Chapter 3. U.S. Next Generation Sequencing Market Variables, Trends & Scope
3.1. Market Lineage Outlook
3.1.1. Parent market outlook
3.1.2. Related/ancillary market outlook
3.2. Market Dynamics
3.2.1. Market driver analysis
3.2.1.1. Rising incidence of cancer and genetic disorders
3.2.1.2. Advancements in sequencing technologies
3.2.2. Market restraint analysis
3.2.2.1. Lack of computational efficiency for data management
3.2.2.2. Non-value-based NGS reimbursement policy and regulation status
3.2.2.3. Challenges associated with NGS implementation.
3.3. U.S. Next Generation Sequencing Market Analysis Tools
3.3.1. SWOT analysis; by factor (political & legal, economic, and technological)
3.3.2. Porter’s Five Forces Analysis
Chapter 4. U.S. Next Generation Sequencing Market: Technology Business Analysis
4.1. Next Generation Sequencing Market: Technology Movement Analysis
4.2. Targeted Sequencing & Resequencing
4.2.1. Targeted Sequencing & Resequencing Market Estimates and Forecast, 2021-2033 (USD Million)
4.2.1.1. DNA-based targeted sequencing & resequencing
4.2.1.1.1. DNA-based targeted sequencing & resequencing market estimates and forecast, 2021-2033 (USD Million)
4.2.1.2. RNA-based targeted sequencing & resequencing
4.2.1.2.1. RNA -based targeted sequencing & resequencing market estimates and forecast, 2021-2033 (USD Million)
4.3. Whole Genome Sequencing
4.3.1. Whole Genome Sequencing Market Estimates and Forecast, 2021-2033 (USD Million)
4.4. Whole Exome Sequencing
4.4.1. Whole Exome Sequencing Market Estimates and Forecast, 2021-2033 (USD Million)
Chapter 5. U.S. Next Generation Sequencing Market: Product Business Analysis
5.1. Next Generation Sequencing Market: Product Movement Analysis
5.2. Platforms
5.2.1. Platforms Market Estimates and Forecast, 2021-2033 (USD Million)
5.2.1.1. Sequencing
5.2.1.1.1. Sequencing platforms market estimates and forecast, 2021-2033 (USD Million)
5.2.1.2. Data Analysis
5.2.1.2.1. Data analysis platforms market estimates and forecast, 2021-2033 (USD Million
5.3. Consumables
5.3.1. Consumables market estimates and forecast, 2021-2033 (USD million)
5.3.2. Sample Preparation
5.3.2.1. Sample preparation market estimates and forecast, 2021-2033 (USD Million)
5.3.3. Target Enrichment
5.3.3.1. Target enrichment market estimates and forecast, 2021-2033 (USD Million)
5.3.4. Others
5.3.4.1. Others market estimates and forecast, 2021-2033 (USD Million)
Chapter 6. U.S. Next Generation Sequencing Market: Application Business Analysis
6.1. Next Generation Sequencing Market: Application Movement Analysis
6.2. Oncology
6.2.1. Oncology Market Estimates and Forecast, 2021-2033 (USD Million)
6.2.2. Diagnostics & Screening
6.2.2.1. Diagnostics & screening market estimates and forecast, 2021-2033 (USD Million)
6.2.2.2. Oncology screening
6.2.2.2.1. Oncology screening market estimates and forecast, 2021-2033 (USD Million)
6.2.2.2.2. Sporadic cancer screening market estimates and forecast, 2021-2033 (USD Million)
6.2.2.2.3. Inherited cancer screening market estimates and forecast, 2021-2033 (USD Million)
6.2.2.3. Companion diagnostics
6.2.2.3.1. Companion diagnostics market estimates and forecast, 2021-2033 (USD Million)
6.2.2.4. Other diagnostics
6.2.2.4.1. Other diagnostics market estimates and forecast, 2021-2033 (USD Million)
6.2.3. Research Studies
6.2.3.1. Research studies market estimates and forecast, 2021-2033 (USD Million)
6.3. Clinical investigation
6.3.1. Clinical investigation market estimates and forecast, 2021-2033 (USD Million)
6.3.2. Infectious Diseases
6.3.2.1. Infectious diseases market estimates and forecast, 2021-2033 (USD Million)
6.3.3. Idiopathic Diseases
6.3.3.1. Idiopathic diseases market estimates and forecast, 2021-2033 (USD Million)
6.3.4. Inherited Diseases
6.3.4.1. Inherited diseases market estimates and forecast, 2021-2033 (USD Million)
6.3.5. Non-Communicable/Other Diseases
6.3.5.1. Non-communicable/other diseases market estimates and forecast, 2021-2033 (USD Million)
6.4. Reproductive Health
6.4.1. Reproductive Health Market Estimates and Forecast, 2021-2033 (USD Million)
6.4.2. NIPT
6.4.2.1. NIPT market estimates and forecast, 2021-2033 (USD Million)
6.4.2.2. Aneuploidy
6.4.2.2.1. Aneuploidy market estimates and forecast, 2021-2033 (USD Million)
6.4.2.3. Microdeletions
6.4.2.3.1. Microdeletions market estimates and forecast, 2021-2033 (USD Million)
6.4.3. PGT
6.4.3.1. PGT market estimates and forecast, 2021-2033 (USD Million)
6.4.4. Newborn Genetic Screening
6.4.4.1. Newborn genetic screening market estimates and forecast, 2021-2033 (USD Million)
6.4.5. Single Gene Analysis
6.4.5.1. Single gene analysis market estimates and forecast, 2021-2033 (USD Million)
6.5. HLA Typing/Immune System Monitoring
6.5.1. HLA Typing/Immune System Monitoring Market Estimates and Forecast, 2021-2033 (USD Million)
6.6. Metagenomics, Epidemiology & Drug Development
6.6.1. Metagenomics, Epidemiology & Drug Development Market Estimates and Forecast, 2021-2033 (USD Million)
6.7. Agrigenomics & Forensics
6.7.1. Agrigenomics & Forensics Market Estimates and Forecast, 2021-2033 (USD Million)
6.8. Consumer Genomics
6.8.1. Consumer Genomics Market Estimates and Forecast, 2021-2033 (USD Million)
Chapter 7. U.S. Next Generation Sequencing Market: Workflow Business Analysis
7.1. Next Generation Sequencing Market: Workflow Movement Analysis
7.2. Pre sequencing
7.2.1. Pre-Sequencing Market Estimates and Forecast, 2021-2033 (USD Million)
7.2.1.1. Nucleic acid extraction
7.2.1.1.1. Nucleic acid extraction market estimates and forecast, 2021-2033 (USD Million)
7.2.1.2. Library preparation
7.2.1.2.1. Library preparation market estimates and forecast, 2021-2033 (USD Million)
7.3. Sequencing
7.3.1. Sequencing Market Estimates and Forecast, 2021-2033 (USD Million)
7.4. Data Analysis
7.4.1. Data Analysis Market Estimates and Forecast, 2021-2033 (USD Million)
7.4.2. Primary Data NGS Analysis
7.4.2.1. Primary data analysis market estimates and forecast, 2021-2033 (USD Million)
7.4.3. Secondary Data Analysis
7.4.3.1. Secondary data analysis market estimates and forecast, 2021-2033 (USD Million)
7.4.4. Tertiary Data Analysis
7.4.4.1. Tertiary data analysis market estimates and forecast, 2021-2033 (USD Million)
Chapter 8. U.S. Next Generation Sequencing Market: End Use Business Analysis
8.1. Next Generation Sequencing Market: End-use Movement Analysis
8.2. Academic Research
8.2.1. Academic Research Market Estimates and Forecast, 2021-2033 (USD Million)
8.3. Clinical Research
8.3.1. Clinical Research Market Estimates and Forecast, 2021-2033 (USD Million)
8.4. Hospitals & Clinics
8.4.1. Hospitals & Clinics Market Estimates and Forecast, 2021-2033 (USD Million)
8.5. Pharmaceutical & Biotech Entities
8.5.1. Pharmaceutical & Biotech Entities Market Estimates and Forecast, 2021-2033 (USD Million)
8.6. Other Users
8.6.1. Other Users Market Estimates and Forecast, 2021-2033 (USD Million)
Chapter 9. Competitive Landscape
9.1. Recent Developments & Impact Analysis, by Key Market Participants
9.2. Company/Competition Categorization
9.3. Market position analysis, 2024
9.4. Participants Overview
9.4.1. Illumina, Inc
9.4.1.1. Company overview
9.4.1.2. Financial Performance
9.4.1.3. Product benchmarking
9.4.1.4. Strategic initiatives
9.4.2. Thermo Fisher Scientific Inc.
9.4.2.1. Company overview
9.4.2.2. Financial Performance
9.4.2.3. Product benchmarking
9.4.2.4. Strategic initiatives
9.4.3. Eurofins Scientific SE
9.4.3.1. Company overview
9.4.3.2. Financial Performance
9.4.3.3. Product benchmarking
9.4.3.4. Strategic initiatives
9.4.4. Eurofins Scientific SE
9.4.4.1. Company overview
9.4.4.2. Financial Performance
9.4.4.3. Product benchmarking
9.4.4.4. Strategic initiatives
9.4.5. QIAGEN
9.4.5.1. Company overview
9.4.5.2. Financial Performance
9.4.5.3. Product benchmarking
9.4.5.4. Strategic initiatives
9.4.6. Quest Diagnostics Incorporated
9.4.6.1. Company overview
9.4.6.2. Financial Performance
9.4.6.3. Product benchmarking
9.4.6.4. Strategic initiatives
9.4.7. Azenta Life Sciences (GENEWIZ)
9.4.7.1. Company overview
9.4.7.2. Financial Performance
9.4.7.3. Product benchmarking
9.4.7.4. Strategic initiatives
9.4.8. NanoString
9.4.8.1. Company overview
9.4.8.2. Financial Performance
9.4.8.3. Product benchmarking
9.4.8.4. Strategic initiatives
9.4.9. PacBio
9.4.9.1. Company overview
9.4.9.2. Financial Performance
9.4.9.3. Product benchmarking
9.4.9.4. Strategic initiatives
9.4.10. BioMérieux
9.4.10.1. Company overview
9.4.10.2. Financial Performance
9.4.10.3. Product benchmarking
9.4.10.4. Strategic initiatives
9.4.11. BGI Group
9.4.11.1. Company overview
9.4.11.2. Financial Performance
9.4.11.3. Product benchmarking
9.4.11.4. Strategic initiatives
9.4.12. F. Hoffmann-La Roche Ltd
9.4.12.1. Company overview
9.4.12.2. Financial Performance
9.4.12.3. Product benchmarking
9.4.12.4. Strategic initiatives
9.4.13. ARUP Laboratories
9.4.13.1. Company overview
9.4.13.2. Financial Performance
9.4.13.3. Product benchmarking
9.4.13.4. Strategic initiatives
9.4.14. Novogene Co, Ltd.
9.4.14.1. Company overview
9.4.14.2. Financial Performance
9.4.14.3. Product benchmarking
9.4.14.4. Strategic initiatives
9.4.15. Gene by Gene Ltd.
9.4.15.1. Company overview
9.4.15.2. Financial Performance
9.4.15.3. Product benchmarking
9.4.15.4. Strategic initiatives
9.4.16. Lucigen Corporation
9.4.16.1. Company overview
9.4.16.2. Financial Performance
9.4.16.3. Product benchmarking
9.4.16.4. Strategic initiatives
List of Tables
Table 1 List of Secondary Sources
Table 2 List of Abbreviations
Table 3 U.S. next generation sequencing market, by technology, 2021-2033 (USD Million)
Table 4 U.S. next generation sequencing market, by product, 2021-2033 (USD Million)
Table 5 U.S. next generation sequencing market, by application, 2021-2033 (USD Million)
Table 6 U.S. next generation sequencing market, by workflow, 2021-2033 (USD Million)
Table 7 U.S. next generation sequencing market, by End Use, 2021-2033 (USD Million)
List of Figures
Figure 1 Market research process
Figure 2 Data triangulation techniques
Figure 3 Primary research pattern
Figure 4 Market research approaches
Figure 5 Market formulation & validation
Figure 6 U.S. next generation sequencing market: market outlook
Figure 7 U.S. next generation sequencing competitive insights.
Figure 8 Parent market outlook
Figure 9 Related/ancillary market outlook.
Figure 10 Penetration and growth prospect mapping
Figure 11 Industry value chain analysis
Figure 12 U.S. next generation sequencing market driver impact
Figure 13 U.S. next generation sequencing market restraint impact
Figure 14 U.S. next generation sequencing market strategic initiatives analysis
Figure 15 U.S. next generation sequencing market: Technology movement analysis
Figure 16 U.S. next generation sequencing market: Technology outlook and key takeaways
Figure 17 Targeted sequencing & resequencing market estimates and forecast, 2021-2033 (USD Million)
Figure 18 DNA-based targeted sequencing & resequencing market estimates and forecast, 2021-2033 (USD Million)
Figure 19 RNA -based targeted sequencing & resequencing market estimates and forecast, 2021-2033 (USD Million)
Figure 20 Whole genome sequencing market estimates and forecast, 2021-2033 (USD Million)
Figure 21 Whole exome sequencing market estimates and forecast, 2021-2033 (USD Million)
Figure 22 U.S. Next-generation sequencing market: Product outlook key takeaways
Figure 23 U.S. Next-generation sequencing market: Product movement analysis
Figure 24 Platforms market estimates and forecast, 2021-2033 (USD Million)
Figure 25 Sequencing platforms market estimates and forecast, 2021-2033 (USD Million)
Figure 26 Data analysis platforms market estimates and forecast, 2021-2033 (USD Million)
Figure 27 Consumables market estimates and forecast, 2021-2033 (USD Million)
Figure 28 Sample preparation market estimates and forecast, 2021-2033 (USD Million)
Figure 29 Target enrichment market estimates and forecast, 2021-2033 (USD Million)
Figure 30 Others market estimates and forecast, 2021-2033 (USD Million)
Figure 31 U.S. next generation sequencing Market: Application Movement Analysis
Figure 32 U.S. next generation sequencing market: Application outlook and key takeaways
Figure 33 Oncology market estimates and forecast, 2021-2033 (USD Million)
Figure 34 Diagnostics & screening market estimates and forecast, 2021-2033 (USD Million)
Figure 35 Oncology screening market estimates and forecast, 2021-2033 (USD Million)
Figure 36 Sporadic cancer screening market estimates and forecast, 2021-2033 (USD Million)
Figure 37 Inherited cancer screening market estimates and forecast, 2021-2033 (USD Million)
Figure 38 Companion diagnostics market estimates and forecast, 2021-2033 (USD Million)
Figure 39 Other diagnostics market estimates and forecast, 2021-2033 (USD Million)
Figure 40 Research studies market estimates and forecast, 2021-2033 (USD Million)
Figure 41 Clinical investigation market estimates and forecast, 2021-2033 (USD Million)
Figure 42 Infectious diseases market estimates and forecast, 2021-2033 (USD Million)
Figure 43 Idiopathic diseases market estimates and forecast, 2021-2033 (USD Million)
Figure 44 Inherited diseases market estimates and forecast, 2021-2033 (USD Million)
Figure 45 Non-communicable/other diseases market estimates and forecast, 2021-2033 (USD Million)
Figure 46 Reproductive health market estimates and forecast, 2021-2033 (USD Million)
Figure 47 NIPT market estimates and forecast, 2021-2033 (USD Million)
Figure 48 Aneuploidy market estimates and forecast, 2021-2033 (USD Million)
Figure 49 Microdeletions market estimates and forecast, 2021-2033 (USD Million)
Figure 50 PGT market estimates and forecast, 2021-2033 (USD Million)
Figure 51 Newborn genetic screening market estimates and forecast, 2021-2033 (USD Million)
Figure 52 Single gene analysis market estimates and forecast, 2021-2033 (USD Million)
Figure 53 HLA typing/immune system monitoring market estimates and forecast, 2021-2033 (USD Million)
Figure 54 Metagenomics, epidemiology & drug development market estimates and forecast, 2021-2033 (USD Million)
Figure 55 Agrigenomics & forensics market estimates and forecast, 2021-2033 (USD Million)
Figure 56 Consumer genomics market estimates and forecast, 2021-2033 (USD Million)
Figure 57 U.S. next generation sequencing market: workflow movement analysis
Figure 58 U.S. next generation sequencing market: workflow outlook and key takeaways
Figure 59 Pre-sequencing market estimates and forecast, 2021-2033 (USD Million)
Figure 60 Nucleic acid extraction market estimates and forecast, 2021-2033 (USD Million)
Figure 61 Library preparation market estimates and forecast, 2021-2033 (USD Million)
Figure 62 Automated library preparation market estimates and forecast, 2021-2033 (USD Million)
Figure 63 Sequencing market estimates and forecast, 2021-2033 (USD Million)
Figure 64 Data analysis market estimates and forecast, 2021-2033 (USD Million)
Figure 65 Primary data analysis market estimates and forecast, 2021-2033 (USD Million)
Figure 66 Secondary data analysis market estimates and forecast, 2021-2033 (USD Million)
Figure 67 Tertiary data analysis market estimates and forecast, 2021-2033 (USD Million)
Figure 68 U.S. Next generation sequencing market End Use outlook key takeaways
Figure 69 U.S. Next-generation sequencing market: End Use movement analysis
Figure 70 Academic research market estimates and forecast, 2021-2033 (USD Million))
Figure 71 Clinical research market estimates and forecast, 2021-2033 (USD Million)
Figure 72 Hospitals & clinics market estimates and forecast, 2021-2033 (USD Million)
Figure 73 Pharmaceutical & biotech entities market estimates and forecast, 2021-2033 (USD Million)
Figure 74 Other users market estimates and forecast, 2021-2033 (USD Million)
Figure 75 Market share of key market players- U.S. next generation sequencing market

Companies Mentioned

The leading players profiled in this U.S. Next Generation Sequencing market report include:
  • Illumina, Inc.
  • Thermo Fisher Scientific Inc.
  • Eurofins Scientific SE
  • PerkinElmer, Inc.
  • QIAGEN
  • Quest Diagnostics Incorporated
  • Azenta Life Sciences (GENEWIZ)
  • NanoString
  • PacBio
  • bioMérieux
  • BGI Group
  • F. Hoffmann-La Roche Ltd
  • ARUP Laboratories
  • Novogene Co, Ltd.
  • Gene by Gene Ltd.
  • Lucigen Corporation

Table Information