Animal Models of Disease, Part D, Volume 197 in the Methods in Cell Biology series presents significant advancements in understanding disease mechanisms through animal models. This volume features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.
Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.
Please Note: This is an On Demand product, delivery may take up to 11 working days after payment has been received.
Table of Contents
PrefaceLorenzo Galluzzi, Fernando Aranda, Aitziber Buque and Jos� Manuel Bravo-San Pedro
1. Characterization of Mutants of the Fish Pathogen Flavobacterium psychrophilum.
Mario Garc�a Dom�nguez
2. Cannulation of mesenteric lymphatic vessels in a murine model
Zohaib N. Khan
3. Mouse intestine as a useful model for CFTR electrophysiology function analysis
Maria Chiara Maiuri
4. An immunocompetent mouse model of metastatic triple-negative breast cancer
Mohamed Jemaa
5. Generation of Humanized Bone for Disease Modeling Using Porcine Adipose Tissue-Derived Extracellular Matrix Scaffolds and Human Dental Pulp Stem Cells
Gaskon Ibarretxe, Iratxe Madarieta, Jon Luzuriaga, Nerea Garc�a-Urkia, Jone Salvador-Moya, Beatriz Pardo-Rodr�guez, Patricia Garc�a Gallastegui, Ver�nica Uribe-Etxebarria, Francisco-Javier Fern�ndez-San-Argimiro, Igor Irastorza, Luc�a Jim�nez-Rojo, Beatriz Olalde, Fernando Unda and Jos� Ram�n Pineda
6. The acute 6-OHDA mouse model
Jose A. Morales-Garcia
7. Methodology and evaluation of the induction of experimental autoimmune encephalomyelitis, a murine preclinical model of multiple sclerosis
Maria Luisa Nieto
8. Precise Measurement of Motor Neuron Dysfunction in Drosophila ALS Model via Climbing Assay and Leg Imaging
Yanan Wei, Hongyu Miao, Hadi Najafi and Woo Jae Kim
9. Evaluation of in vivo target cell elimination by antigen-specific cytotoxic T lymphocytes
Gustavo P. Amarante-Mendes, Abolaji S. Olagunju, Isau H. Noronha and Jos� Ronnie C. Vasconcelos
10. A protocol for measuring phenotypical facial disease markers in a mouse model of iatrogenic Cushing’s syndrome.
Oliver Kepp, Guido Kroemer, Hui Pan, Ai-Ling Tian and Isabelle Martins
11. Swiss Webster mice as a model of alcohol overconsumption
Mohamed Jemaa
12. Orthotopic model of tongue cancer for the study of head and neck squamous cell carcinoma in mice
Maria Chiara Maiuri, Jonathan Pol, Guido Kroemer, Sarah Adriana Scuderi, Fatima Domenica Elisa De Palma, Deborah Mannino, Maria Perez-Lanzon, Lionel Deroche, Marie Valet and Pierre Cordier
13. Experimental model of Unilateral Ureteral Obstruction reproduces key events of chronic kidney disease: from mice to humans.cide
Lara Vali�o, Alberto L�zaro Fern�ndez, Elena V�zquez Ogando and Mar�a �ngeles Gonz�lez Nicolas
14. Animal Models of Obesity
Eugenia Morselli
15. Methods for experimentally increasing circulating acyl coenzyme A binding protein (ACBP) levels in mice under chronic restraint stress
ISABELLE MARTINS
16. Assessing mitochondrial number and morphology in a C. elegans model of human tauopathy
Konstantinos Palikaras
