Role of Gut Microbiome in Neurodegenerative Disorders provides an overview of the gut microbiota and its interactions with the gut and the central nervous system. This book reviews the relevance of this axis to the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and Multiple sclerosis (MS). Various chapters discuss the effects of gut derived particles in various parts of brain and the targeting pathways leading to protein deposition in brain.
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Table of Contents
1. Overview of Neurodegenerative Disorders2. Gut Microbiota and Neurological Diseases
3. Gut-Brain Axis
4. Gut-Brain Axis in Neurological Diseases
5. Difference in the constitution of Gut Microbiota during Neurodegenerative Disorders
6. Gut Metabolites in Neurodegenerative Diseases
7. Influence of Gut Microbiota on Cerebellum
8. Influence of Gut Microbiota on Hippocampus
9. Influence of Gut Microbiota on Axonal Cells of the brain
10. Mechanistic action of Gut Microbiota on Glial cells
11. Gut as a second brain- Largest producer of serotonin
12. Gradual Shift of gut microbial Population as a diagnostic marker for Neurodegenerative disorders
13. Gut metabolites effective biomarker for Neurodegenerative disorder
14. Protocol Isolation of Gut Microbiome from Faecal sample
15. Gut metabolites isolation from Blood
16. Metagenomics and sequence analysis
17. Computer aided detection method
18. Existing therapeutic options to alter gut composition in Neurodegenerative Disorders
19. Dietary and Gut microbiome
20. Ongoing clinical trials
21. Ethical hurdles for the treatment of a disease focusing Gut Microbiota
22. Futuristic therapies in pipeline for the betterment of Neurodegenerative Disorders
Authors
Mukesh Kumar Yadav Professor, Department of Microbiology, Central University of Punjab, Bathinda, Punjab, India.Dr. Mukesh Kumar Yadav is working as Professor at the Department of Microbiology, Central University of Punjab, Bathinda, India. Prof. Yadav has more than 15 years of research experience in medical microbiology, particularly in microbial biofilms and host-microbial interactions. Prof. Yadav has published over 110 research articles, garnering more than 7,000 citations, and has authored five books with Elsevier. He has completed eight major research projects funded by the Indian Council of Medical Research (ICMR), the Department of Biotechnology (DBT), the Department of Science and Technology (DST), and the National Research Foundation (South Korea). Prof. Yadav's research area focuses on host-microbial interactions and microbial biofilms, including pathogenic and commensal bacteria in the gut. Prof. Yadav's lab is working on understanding microbial biofilms and infections caused by the biofilm mode of growth, as well as antimicrobial resistance (AMR), and identifying suitable strategies to combat AMR and drug resistance. Understanding Commensal Bacterial Interaction and Dysbiosis of Gut Microbiota during Various Metabolic Disorders.
Balachandar Vellingiri Associate Professor, Neurobiology (Ageing and Pediatric) Laboratory [NAP Lab], Department of Zoology, School of Basic Sciences, Central University of Punjab, Bathinda, Punjab, India.Dr. Balachandar Vellingiri currently is investigating various neurological diseases and developing human induced pluripotent stem cells (HiPSCs). Exploring the cutting-edge molecular, cellular, and translational neuroscience approaches, he aims to unravel disease mechanisms, identify therapeutic targets, and develop innovative interventions to slow or reverse neurological diseases. His expertise is on several techniques such as molecular cytogenetics, pathway analysis, and techniques in developing HiPSCs and Brain organoids, especially for neurological diseases.
