New Developments in Redox Biology: Fundamental Roles in Health and Disease offers a comprehensive exploration of the influence of the redox system and the complex relationships between oxidative stress, biological development, health and disease. Divided into three sections, it explores the role of the redox system across developmental biology, non-communicable diseases, and infectious diseases. The first section includes chapters exploring oxygen availability in embryonic development, the influence of stress factors and intra-cellular signalling during embryogenesis, and how stem cells maintain homeostasis under oxidative stress. Section two considers topics such as the origin of cancer stem cells related to hypoxia, redox-related biomarkers in tumorigenesis and metabolic disorders, and the role of oxidation and reduction systems in autoimmune disorders and neurodegeneration. The final section focuses on redox regulation in infectious illness and includes chapters on redox biomarkers in host-pathogen interaction, the role of redox control in zoonotic diseases, and the significance of hypoxia on the ability of microbial pathogens to invade the gut. Antiviral drugs and the use of redox regulation in their mechanism of action is also explored. New Developments in Redox Biology: Fundamental Roles in Health and Disease offers a multidisciplinary approach to the topic, providing valuable insights to those seeking to expand their expertise in redox biology and its implications for human health and disease. In particular, researchers and advanced students working across molecular biology, cell biology, biochemistry, developmental biology and related fields will find this book useful.
Table of Contents
Section I: The redox theory of developmental biology1. The role of oxygen availability in embryonic development
2. Balancing of oxidants via antioxidant enzymes in developmental biology
3. Antioxidant-mediated O2 sensing epigenetic regulation
4. Genetic basis of phenotypic plasticity in embryo under stress
5. Cellular signalling cascade regulating embryonic development under oxidative stress
6. Intra-cellular signalling cascade shielding against oxidative stress
7. Stem cell homeostasis and differentiation under oxidative stress
8. Multi-omics signature to oxidative response in cell growth & development
Section II: Redox biology modulating non-communicable diseases
9. Origin of cancer stem cells concerning hypoxia
10. Redox-related biomarkers in tumorigenesis
11. Metabolic disorder and its underlying redox biomarkers
12. Redox regulation of autoimmune disorders
13. Altered redox regulatory mechanisms in neurodegeneration
14. Chronic inflammatory disorders and their redox control reaction
15. Redox-related biomarkers in cardiovascular and immune-mediated inflammatory diseases
Section III: Impact of redox regulation on infectious biology
16. Major redox biomarkers in host-pathogen interaction
17. Redox control in the pathophysiology of zoonoses
18. Antiviral therapeutics and their redox regulation
19. The impact of hypoxia on intestinal invasion by bacterial pathogens
20. Natural antioxidant therapeutics against microbial infection
21. Redox profiling of pathogenic infection in poultry farms
Authors
Asim K. Duttaroy Faculty of Medicine, University of Oslo, Oslo, Norway. Dr. Asim K. Duttaroy is a professor at the Faculty of Medicine, University of Oslo, Oslo, Norway. His research programs focus on the roles of food components on growth and development, as well as in the prevention of diseases such as diabetes and cardiovascular disease. He is also investigating the roles of the antiplatelet and antihypertensive properties of fruits and vegetables. His discoveries of antithrombotic factors in tomatoes and kiwifruits are patented internationally, and three companies (Provexis Limited in the United Kingdom, IDIA AS in Norway, and Genimen Pharmacon in India) are working to commercialize these discoveries. He has published over 265 original contributions and reviews, 6 books, and several book chapters and editorials, and he is the Editor-in-Chief of the journal Food & Nutrition Research, as well as a guest editor of several journals such as Nutrients and Frontiers in Physiology. Atala Bihari Jena National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune, India.Dr. Atala Bihari Jena has a PhD in Biotechnology and over 7 years of experience in redox biology. He is an MK-Bhan Fellow at the National Center for Cell Science, Savitribai Phule Pune University, India and his main research expertise centres on oxidative stress, antioxidant enzymes, antioxidants, and the cellular redox system in health and disease.
