Post Operative Pain Management Global Market Report 2025

The postoperative pain management market size has grown strongly in recent years. It will grow from $37.03 billion in 2024 to $39.38 billion in 2025 at a compound annual growth rate (CAGR) of 6.4%. The growth during the historic period can be attributed to the rising demand for pain management drugs, the increasing prevalence of chronic diseases, a growing number of cancer patients undergoing surgery, a rise in traffic accidents and related trauma injuries, and an overall increase in surgical procedures.

The postoperative pain management market size is expected to see strong growth in the next few years. It will grow to $49.89 billion in 2029 at a compound annual growth rate (CAGR) of 6.1%. The growth in the forecast period can be attributed to the rising adoption of multimodal analgesic approaches, increasing demand for non-opioid-based analgesics, advancements in research and development, a growing emphasis on palliative care, and a higher number of surgical procedures. Key trends include the development of innovative drugs, personalized treatment strategies, technological advancements, the integration of digital health technologies, advanced pain management solutions, and the expansion of telemedicine.

The increasing number of surgical procedures is expected to drive the growth of the postoperative pain management market. Surgical procedures involve medical operations performed by trained surgeons to diagnose, treat, or manage diseases, injuries, or conditions. The rise in surgical procedures is influenced by factors such as an aging population, the increasing prevalence of chronic diseases, advancements in medical technology, improved healthcare access, and a growing demand for elective surgeries. Effective postoperative pain management plays a crucial role in enhancing recovery, reducing complications, improving patient comfort, and supporting better surgical outcomes by controlling pain and enabling faster rehabilitation. For example, in December 2023, the UK Health Security Agency reported an increase in coronary artery bypass graft surgeries, with 27,524 procedures performed in 2023 compared to previous years. Consequently, the rising number of surgical procedures is contributing to the expansion of the postoperative pain management market.

Leading companies in the postoperative pain management market are investing in technological advancements, such as cryoablation probes, to provide more effective pain relief by targeting nerves with controlled cooling. Cryoablation probes are medical devices designed to freeze and destroy targeted nerve tissues or abnormal cells, commonly used for pain management or tumor treatment. In October 2024, AtriCure Inc., a US-based medical device company, introduced the cryoSPHERE MAX, a next-generation probe designed to improve postoperative pain management. This device temporarily blocks pain by precisely freezing peripheral nerves, reducing freeze times, and enhancing tissue contact for more efficient and effective pain relief. It features advancements in insulation, Nitrous Oxide gas usage, tactile tissue feedback, and real-time temperature monitoring.

In January 2024, Heron Therapeutics, Inc., a US-based biotechnology company, partnered with Cross Link Life Sciences LLC to expand its sales network and improve access to Zynrelef, a postoperative pain management solution for orthopedic surgery patients. Cross Link Life Sciences LLC, a US-based medical device company, specializes in innovative solutions for surgical and pain management applications. This partnership aims to enhance the availability of advanced pain management options and improve patient outcomes in the postoperative care market.

Major players in the post operative pain management market are Johnson & Johnson, Merck & Co. Inc., Bayer AG, Novartis AG, Sun Pharmaceutical Industries Ltd., Cipla Inc., Hikma Pharmaceuticals PLC, Mallinckrodt plc, Pacira BioSciences Inc, Endo International plc, AFT Pharmaceuticals Limited, Heron Therapeutics Inc., Cara Therapeutics Inc., Teikoku Pharma USA Inc, Allay Therapeutics Inc, PainReform Ltd, Scilex Pharmaceuticals Inc., Taiwan Liposome Company Ltd, Concentric Analgesics Inc., Durect Corporation, Neumentum Inc., Trevena Inc., and Virpax Pharmaceuticals Inc.

North America was the largest region in the postoperative pain management market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in postoperative pain management report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the postoperative pain management market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Postoperative pain management encompasses the strategies and treatments used to alleviate pain following a surgical procedure. It includes both pharmacological and non-pharmacological approaches aimed at enhancing patient comfort, promoting recovery, minimizing complications, and improving overall surgical outcomes.

The primary types of pain managed after surgery include acute pain, moderate pain, and severe pain. Acute pain is a sudden and sharp sensation that persists for a short period, typically resulting from injury, surgery, or illness. Various drug classes are utilized for pain management, including opioids, non-steroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase-2-selective inhibitors (COX-2 inhibitors), and other medications. These drugs can be administered through different routes, such as injectable, oral, and topical forms, and are distributed through hospital and retail pharmacies. The applications of pain management extend to conditions such as cancer pain, arthritic pain, neuropathic pain, musculoskeletal pain, and migraines.

The post-operative pain management market research report is one of a series of new reports that provides post-operative pain management market statistics, including the post-operative pain management industry global market size, regional shares, competitors with the post-operative pain management market share, detailed post-operative pain management market segments, market trends, and opportunities, and any further data you may need to thrive in the post-operative pain management industry. This post-operative pain management market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The postoperative pain management market consists of revenues earned by entities by providing services such as pharmacological treatments, treatment services, physical therapy and rehabilitation, and psychological support and counseling. The market value includes the value of related goods sold by the service provider or included within the service offering. The postoperative pain management market also includes sales of pharmaceuticals, patient-controlled analgesia (PCA) pumps, cryotherapy, and heat therapy devices. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values, which refer to the revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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