Cardiotonic Agents Global Market Report 2025

The cardiotonic agents market size has grown rapidly in recent years. It will grow from $2.78 billion in 2024 to $3.14 billion in 2025 at a compound annual growth rate (CAGR) of 12.9%. The growth during the historic period can be attributed to the rising prevalence of heart failure, an expanding elderly population, an increasing incidence of coronary artery disease, greater adoption of sedentary lifestyles, and the growing burden of hypertension and diabetes.

The cardiotonic agents market size is expected to see rapid growth in the next few years. It will grow to $5.06 billion in 2029 at a compound annual growth rate (CAGR) of 12.6%. The growth in the forecast period can be attributed to increasing cardiovascular mortality rates, a rise in clinical trials focused on enhanced cardiotonic formulations, expanding public-private collaborations in cardiovascular drug development, growing hospital admissions related to cardiac complications, and heightened demand for personalized cardiovascular medicine. Key trends during the forecast period include the development of peptide-based cardiotonic agents, creation of dual-mechanism drugs, integration of pharmacogenomics, innovation in injectable depot formulations, and advancement of combination therapies.

The increasing prevalence of cardiovascular diseases is expected to drive growth in the cardiotonic agents market in the coming years. Cardiovascular diseases (CVDs) include a group of disorders affecting the heart and blood vessels, such as coronary artery disease, heart failure, arrhythmias, and stroke. This rise is largely attributed to unhealthy diets rich in saturated fats, trans fats, salt, and added sugars, which contribute to obesity, high blood pressure, and elevated cholesterol levels. Cardiotonic agents work by enhancing the heart muscle’s efficiency and contraction strength, thereby supporting improved blood circulation and alleviating symptoms in various cardiovascular conditions. For example, in December 2023, the Australian Institute of Health and Welfare, an Australian government agency, reported that doctor-certified deaths due to coronary heart disease (CHD) increased from 14,100 in 2021 to 14,900 in 2022. Consequently, the rising prevalence of cardiovascular diseases is fueling the growth of the cardiotonic agents market.

Leading companies in the cardiotonic agents market are developing innovative products, including short-term inotropic drugs, aimed at improving cardiac performance in acute heart failure and cardiogenic shock. Short-term inotropic drugs are used to temporarily increase the heart’s contractility, which enhances cardiac output. For instance, in June 2023, Hikma Pharmaceuticals plc, a UK-based pharmaceutical company, launched Dobutamine Injection, USP, in a 250 mg/20 mL vial. This injection provides short-term inotropic support for adults suffering from cardiac decompensation due to reduced heart contractility, often caused by heart disease or following cardiac surgery. Dobutamine stimulates beta-1 receptors to boost heart muscle contractility and cardiac output with a rapid onset of 1 to 2 minutes. The injection is administered intravenously and is typically used in hospital settings under close medical supervision.

In April 2023, SK Capital Partners LP, a US-based capital market company, acquired Apotex Pharmaceutical Holdings Inc. for an undisclosed sum. This acquisition aims to accelerate Apotex’s growth and innovation by leveraging SK Capital’s expertise to expand global access to affordable, high-quality pharmaceuticals. Apotex Pharmaceutical Holdings Inc., based in Canada, manufactures a cardiotonic agent marketed under the brand name Apo-Digoxin.

Major players in the cardiotonic agents market are Pfizer Inc., F. Hoffmann-La Roche AG, Merck & Co. Inc., Bayer AG, Sanofi S.A., Bristol-Myers Squibb Company, AstraZeneca plc, Novartis AG, Eli Lilly and Company, Fresenius Kabi, Aurobindo Pharma Limited, Hikma Pharmaceuticals PLC, Alchem International Private Ltd, Farbe Firma Private Limited, Salius Pharma Pvt. Ltd., Johnlee Pharmaceuticals Pvt. Ltd., Healthy Life Pharma Pvt Ltd, Anwita Drugs, Varion Lifesciences, and Deccan Nutraceuticals Pvt. Ltd.

North America was the largest region in the cardiotonic agents market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in cardiotonic agents report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the cardiotonic agents market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Cardiotonic agents are a group of drugs that enhance the strength and efficiency of heart muscle contractions, thereby improving the heart’s ability to pump blood. These medications are primarily used to manage heart failure and certain arrhythmias by boosting cardiac output and enhancing blood circulation.

The main categories of cardiotonic agents include digitalis glycosides, phosphodiesterase inhibitors, cardioprotectants, sympathomimetic agents, and others. Digitalis glycosides are compounds extracted from the Digitalis plant, used to treat heart conditions by increasing contraction force and regulating heart rhythm. These drugs can be administered orally, intravenously, or via other methods, with common dosage forms including tablets and solutions. They are utilized in a variety of clinical scenarios such as cardiac surgeries, atrial fibrillation, heart failure, pulmonary hypertension, among others, and are distributed through hospital pharmacies, retail pharmacies, and online pharmacies.

The cardiotonic agents market research report is one of a series of new reports that provides cardiotonic agents market statistics, including cardiotonic agents industry global market size, regional shares, competitors with a cardiotonic agents market share, cardiotonic agents market segments, market trends and opportunities, and any further data you may need to thrive in the cardiotonic agents industry. This cardiotonic agents market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The cardiotonic agents market consists of sales of digoxin, milrinone, dobutamine, levosimendan, and amrinone. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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