Over-The-Counter (OTC) Probiotics Supplements Global Market Report 2025

The over-the-counter (OTC) probiotic supplements market size has grown rapidly in recent years. It will grow from $6.44 billion in 2024 to $7.16 billion in 2025 at a compound annual growth rate (CAGR) of 11.3%. Growth during the historical period was influenced by an expanding elderly population seeking immune system support, a shift toward non-prescription health remedies, heightened awareness of the adverse effects of antibiotics spurring probiotic use, increased interest in personalized nutrition and wellness, and expanding clinical studies backing the effectiveness of probiotics.

The over-the-counter (OTC) probiotic supplements market size is expected to see rapid growth in the next few years. It will grow to $10.91 billion in 2029 at a compound annual growth rate (CAGR) of 11.1%. Forecasted growth is driven by heightened public understanding of gut health, a surge in digestive health issues, increasing preference for natural and preventive health products, greater adoption of healthy living practices, and a growing consumer shift toward functional foods and dietary supplements. Key trends expected during this period include innovations in encapsulation technology to improve probiotic viability, the introduction of multi-strain formulas offering enhanced health benefits, advancements in genetic analysis allowing more precise strain targeting, combination products that merge probiotics with prebiotics to create synbiotics, and the emergence of clinically tested probiotics with substantiated health claims.

The rising prevalence of digestive disorders is anticipated to drive the growth of the over-the-counter (OTC) probiotic supplements market. Digestive disorders, which affect the gastrointestinal tract, can hinder digestion, nutrient absorption, or the elimination of waste. These conditions are becoming more common due to poor dietary habits, including the consumption of processed and low-fiber foods that negatively impact gut health. OTC probiotic supplements help support digestive health by maintaining a balanced gut microbiome, benefiting those with digestive issues. These supplements aid in nutrient absorption and help alleviate symptoms like bloating, constipation, and diarrhea, thereby enhancing overall gastrointestinal wellness. For example, according to the IBD Registry, a UK-based non-profit organization, the number of people living with inflammatory bowel disease - a chronic condition causing gut inflammation - rose to 5,300 in 2023, an increase of more than 3,000 from 2022. This growing prevalence of digestive disorders is boosting demand for OTC probiotic supplements.

Leading companies in the OTC probiotic supplements market are focusing on developing innovative probiotic formulations, such as drink mixes, to improve bioavailability, product stability, and ease of use. A probiotic drink mix is typically a powdered or granulated product containing live beneficial bacteria that can be dissolved in liquids to create a probiotic-enriched beverage. For instance, in September 2024, ZBiotics, a US-based biotechnology company, launched a genetically engineered probiotic drink mix that transforms dietary sugar (sucrose) into rare prebiotic levan fiber within the gut. This supports microbiome diversity and promotes gut health without requiring dietary changes. The product provides up to 10 grams of fiber throughout the day, contributing to improved digestion, immune function, and nutrient absorption.

In January 2024, Dr. Reddy’s Laboratories Ltd., an India-based pharmaceutical company, acquired the MenoLabs supplements portfolio from Amyris Inc. for an undisclosed sum. The acquisition aims to enhance Dr. Reddy’s position in the women’s wellness sector by expanding its range of menopause-related OTC probiotic supplements. MenoLabs is a US-based brand focused on women’s health and technology, offering various probiotic-based solutions for menopause support.

Major players in the over-the-counter (otc) probiotics supplements market are Nestlé S.A., Pfizer Inc., Procter & Gamble, Probi AB, Bayer AG, Sanofi S.A., Abbott Laboratories, Danone S.A., Pharmavite LLC, ADM Protexin Limited, Now Foods, Thorne HealthTech Inc, Garden of Life LLC, Lifeway Foods Inc., BioGaia AB, Biocodex Inc, OptiBac Probiotics, i-Health Inc., Symprove Ltd., Bio-Kult, BLIS Technologies Ltd., Goerlich Pharma GmbH, BelliWelli Inc., Custom Probiotics Inc., Kibow Biotech Inc., Orthomol Holding GmbH, Swanson Health Products Inc., JB7 LLC.

North America was the largest region in the over-the-counter (OTC) probiotic supplements market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in over-the-counter (OTC) probiotic supplements report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the over-the-counter (OTC) probiotic supplements market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Over-the-counter (OTC) probiotic supplements are non-prescription dietary products that contain live beneficial bacteria or yeasts designed to support gut health. These supplements help maintain or reestablish the natural balance of gut microbiota. OTC probiotic supplements assist in digestion, boost immune function, and contribute to overall gastrointestinal wellness.

The primary forms of over-the-counter (OTC) probiotic supplements include capsules, tablets, powders, liquids, and gummies. Capsules contain probiotic strains encased in gelatin or plant-derived shells. Common probiotic strains featured in these supplements include Lactobacillus, Streptococcus, and Bifidobacterium. They are available through several distribution channels such as online pharmacies, health and wellness outlets, supermarkets or hypermarkets, specialty stores, and direct sales. These supplements are used for various purposes, including digestive health, immune enhancement, weight control, mental health, and women’s health, catering to different end users like adults, children, and infants.

The OTC probiotics supplements market research report is one of a series of new reports that provides OTC probiotics supplements market statistics, including the OTC probiotics supplements industry's global market size, regional shares, competitors with the OTC probiotics supplements market share, detailed OTC probiotics supplements market segments, market trends and opportunities, and any further data you may need to thrive in the OTC probiotics supplements market. This OTC probiotic supplements market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The over-the-counter (OTC) probiotic supplements market consists of sales of saccharomyces boulardii, and probiotic strains. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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