Neurodegenerative Disease Global Market Report 2025

The neurodegenerative disease market size has grown strongly in recent years. It will grow from $52.3 billion in 2024 to $57.23 billion in 2025 at a compound annual growth rate (CAGR) of 9.4%. Growth in the historic period was driven by enhanced diagnostic capabilities, increased demand for symptomatic treatments, more clinical trial activity, strengthened public-private partnerships, and a growing burden of unmet medical needs.

The neurodegenerative disease market size is expected to see strong growth in the next few years. It will grow to $81.23 billion in 2029 at a compound annual growth rate (CAGR) of 9.2%. This anticipated growth is attributed to advancements in gene and cell therapy, increased use of digital biomarkers, a rise in precision medicine strategies, expansion of disease-modifying drug pipelines, and greater adoption of artificial intelligence in neurology. Notable trends expected during the forecast period include progress in neuroimaging technologies, advanced brain-targeted drug delivery systems, personalized treatment innovations, biomarker discovery breakthroughs, and advancements in gene editing techniques.

The increase in research and clinical trials is expected to propel the growth of the neurodegenerative disease market going forward. Clinical trials refer to research studies conducted with human participants to evaluate the safety, efficacy, and potential side effects of new treatments, drugs, or medical devices. The rise in research and clinical trials is primarily driven by the growing demand for new treatments to meet evolving healthcare needs and enhance patient outcomes. These trials play a crucial role in neurodegenerative disease research by generating essential data on the safety and effectiveness of new therapies, thereby advancing therapeutic development and improving patient care. For instance, in November 2023, according to a report published by the Association of the British Pharmaceutical Industry (ABPI), a UK-based association, the total number of industry clinical trials initiated annually in the UK rose slightly by 4.3%, from 394 trials in 2021 to 411 in 2022. Therefore, the increase in research and clinical trials is expected to drive the growth of the neurodegenerative disease market.

Major companies operating in the neurodegenerative disease market are focusing on developing innovative products such as next-generation adaptive Deep Brain Stimulation (aDBS) systems, aiming to improve treatment precision, enhance disease-modifying effects, and increase patient quality of life. Next-generation adaptive deep brain stimulation (aDBS) systems are advanced neurostimulation devices designed to deliver real-time, personalized treatment for Parkinson's disease by dynamically adjusting stimulation parameters based on neural feedback. This optimizes therapeutic effects and minimizes side effects, resulting in better patient outcomes. For example, in February 2025, Medtronic, a US-based medical technology company, received approval from the U.S. Food and Drug Administration (USFDA) for the world’s first adaptive deep brain stimulation (aDBS) system for Parkinson’s disease. This approval covers the premarket approval (PMA) application for the Percept RC neurostimulator with BrainSense technology, which automatically adjusts therapy in response to a patient’s brain signals. The system is clinically validated to provide symptom relief for advanced Parkinson’s disease patients and represents a major advancement in personalized neuromodulation therapies.

In December 2024, AbbVie, a US-based biopharmaceutical company, acquired Aliada Therapeutics for an undisclosed amount. Through this acquisition, AbbVie aims to advance potentially disease-modifying therapies for Alzheimer’s disease and enhance its neuroscience pipeline by utilizing Aliada’s innovative drug delivery platform capable of crossing the blood-brain barrier. Aliada Therapeutics is a US-based company that develops precision medicines for neurological disorders.

Major players in the neurodegenerative disease market are Pfizer Inc., Johnson & Johnson, F. Hoffmann-La Roche Ltd, AbbVie Inc., Sanofi S.A., Novartis AG, Takeda Pharmaceutical Company Limited, Eli Lilly and Company, Merck & Co. Inc., Biogen Inc., Neurocrine Biosciences Inc., Alnylam Pharmaceuticals Inc., Ionis Pharmaceuticals Inc., Cassava Sciences Inc., Denali Therapeutics Inc., Voyager Therapeutics Inc., AC Immune SA, Amylyx Pharmaceuticals Inc., Sage Therapeutics Inc., Alzheon Inc.

North America was the largest region in the neurodegenerative disease market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in neurodegenerative disease report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the neurodegenerative disease market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Neurodegenerative disease encompasses a group of disorders marked by the progressive deterioration of the structure and function of the nervous system, including the brain and spinal cord. The primary objective in this field is to understand, diagnose, and treat these conditions through advancements in biotechnology, pharmaceuticals, and medical technology. The aim is to slow disease progression, enhance patient outcomes, and lessen the burden on healthcare systems. This field also supports aging populations, improves neurological care, and contributes to a sustainable, technology-driven healthcare infrastructure.

The main types of neurodegenerative diseases include Parkinson's disease, Alzheimer's disease, multiple sclerosis, Huntington's disease, and amyotrophic lateral sclerosis. Parkinson's disease is a progressive neurological condition that impairs movement control due to the degeneration of dopamine-producing brain cells. These conditions are managed using various drug types such as N-methyl-D-aspartate (NMDA) receptor antagonists, cholinesterase inhibitors, dopamine agonists, and immunomodulatory drugs. Administration routes include oral, injectable, transdermal, and other methods. The drugs are distributed through hospital pharmacies, retail pharmacies, online pharmacies, and other distribution channels. Key end-users include hospitals, retail providers, and online platforms.

The neurodegenerative diseases market research report is one of a series of new reports that provides neurodegenerative diseases market statistics, including the neurodegenerative diseases industry global market size, regional shares, competitors with the neurodegenerative diseases market share, detailed neurodegenerative diseases market segments, market trends, and opportunities, and any further data you may need to thrive in the neurodegenerative diseases industry. This neurodegenerative diseases market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The neurodegenerative disease market consists of revenues earned by entities through services such as biotechnology research, pharmaceutical development, diagnostic solutions, medical technologies, and patient care advancements aimed at understanding, diagnosing, and treating neurodegenerative conditions. The market value includes the value of related goods sold by the service provider or included within the service offering. The neurodegenerative disease market also includes sales of pharmaceuticals, biotechnology treatments, medical devices, and diagnostic tools aimed at managing and treating neurodegenerative conditions. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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