Affinity Chromatography Global Market Report 2025

The affinity chromatography market size has grown strongly in recent years. It will grow from $3.44 billion in 2024 to $3.68 billion in 2025 at a compound annual growth rate (CAGR) of 7%. The growth during the historic period can be attributed to the rising demand for protein purification, advancements in personalized medicine, increased investments in academic and industrial R&D, greater adoption of monoclonal antibodies, and the expansion of proteomics and genomics research.

The affinity chromatography market size is expected to see strong growth in the next few years. It will grow to $4.76 billion in 2029 at a compound annual growth rate (CAGR) of 6.6%. The growth in the forecast period can be attributed to the expansion of the biopharmaceutical industry, rising demand for gene and cell therapies, an increase in biosimilar production, growing focus on continuous bioprocessing, and stricter regulatory requirements for biologics purity. Key trends expected during this period include integration with single-use technologies, a move toward automation and high-throughput screening, the creation of innovative ligands and resins, applications in diagnostics and biomarker discovery, and the extension of use into non-biopharmaceutical sectors.

The increasing demand for biopharmaceuticals is anticipated to drive the growth of the affinity chromatography market in the coming years. Biopharmaceuticals are therapeutic products derived from biological sources, such as living cells or organisms, and are used to treat, prevent, or diagnose various diseases. This demand is growing primarily because biopharmaceuticals provide highly targeted and effective treatments for complex conditions like cancer and autoimmune disorders, leading to improved patient outcomes where conventional drugs often prove inadequate. Affinity chromatography plays a critical role by enabling the precise and efficient purification of complex biomolecules, including antibodies and proteins, which is essential for producing high-quality biopharmaceuticals. For example, in July 2024, the UK Department for Science, Innovation, and Technology reported that the U.S. leads the global biopharmaceutical sector, with companies investing approximately $96 billion in R&D in 2023, representing over 20% of their total sales. The sector also generated significant economic value, with $25 billion in exports and $26 billion in R&D from predominantly foreign-owned firms in 2022. As a result, the growing demand for biopharmaceuticals is set to accelerate the expansion of the affinity chromatography market.

Leading companies in the affinity chromatography market are concentrating on the development of advanced technologies, such as next-generation affinity chromatography units, to enable faster, more flexible, and efficient antibody purification in laboratory environments. These innovations mark a significant advancement in purification systems by offering improved specificity, scalability, and automation, often featuring novel ligands and enhanced resin materials to address the evolving needs of biopharmaceutical research and manufacturing. For example, in October 2024, Sartorius, a Germany-based pharmaceutical company, introduced the Sartobind Rapid A Lab, a Protein A affinity chromatography unit. This unit incorporates the fastest available Protein A matrix, significantly boosting productivity and transforming antibody purification. Tailored for research scientists, it offers a plug-and-play benchtop system that supports rapid cycling without requiring buffer degassing. Its membrane design resists clogging and maintains stable backpressure, ensuring consistent performance with syringes, pumps, or chromatography systems across up to 100 purification cycles. Throughout its consumable lifespan, it can deliver up to 17 times more antibody yield than traditional resin-based columns.

In July 2024, Repligen, a US-based life sciences company, acquired Tantti Laboratory Inc. for an undisclosed sum. Through this acquisition, Repligen gains access to Tantti’s macroporous chromatography beads, which are used in the purification of viral vectors, viruses, nucleic acids, and other advanced modalities. The acquisition is intended to strengthen and expand Repligen’s portfolio in the rapidly growing area of new modality bioprocessing. Tantti Laboratory Inc. is a Taiwan-based manufacturer of affinity chromatography products.

Major players in the affinity chromatography market are Thermo Fisher Scientific, Merck KGaA, Asahi Kasei Medical Co. Ltd., GE Healthcare Life Sciences, MilliporeSigma, Lonza Group Ltd., Agilent Technologies, Cytiva, Sartorius AG, Tosoh Bioscience, Waters Corporation, Bio-Rad Laboratories, Pall Corporation, Promega Corporation, Biotage, Horizon Discovery, KNAUER Wissenschaftliche Geräte GmbH, BioWorks Inc., BIA Separation, JNC Corporation.

North America was the largest region in the affinity chromatography market in 2024. The regions covered in affinity chromatography report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the affinity chromatography market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Affinity chromatography is a highly specific separation method employed to isolate particular molecules from a complex mixture through distinct biological interactions. This technique is based on the selective binding between a target molecule and a complementary partner that is immobilized on a solid matrix.

The primary products used in affinity chromatography include resins or gels, columns, magnetic beads, reagents and consumables, and accessories. Resins or gels contain ligands that bind specifically to target molecules, enabling the process of separation and purification. Various approaches are utilized, such as immobilized metal affinity chromatography, protein A, G, or L affinity chromatography, bio-specific affinity chromatography, among others, and are applied in biomolecule purification and chromatographic separation. This technique is employed by diverse end users, such as pharmaceutical and biotechnology firms, research centers, and academic institutions.

The affinity chromatography market research report is one of a series of new reports that provides affinity chromatography market statistics, including affinity chromatography industry global market size, regional shares, competitors with a affinity chromatography market share, detailed affinity chromatography market segments, market trends and opportunities, and any further data you may need to thrive in the affinity chromatography industry. This affinity chromatography market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The affinity chromatography market consists of revenues earned by entities by providing services such as custom ligand development, column packing and preparation, protein purification services, and process optimization. The market value includes the value of related goods sold by the service provider or included within the service offering. The affinity chromatography market also includes sales of chromatography media and supports, elution buffers, affinity tags, and labeling kits. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

This product will be delivered within 3-5 business days.