Single-Use Chromatography Membrane Global Market Report 2025

The single-use chromatography membrane market size has grown rapidly in recent years. It will grow from $1.14 billion in 2024 to $1.32 billion in 2025 at a compound annual growth rate (CAGR) of 15.9%. The growth in the historic period can be attributed to the expansion of biopharmaceutical production capacity, rising demand for monoclonal antibodies, increasing importance of bioprocessing operations, growing emphasis on sustainable manufacturing practices, and the escalating demand for biologics and vaccines.

The single-use chromatography membrane market size is expected to see rapid growth in the next few years. It will grow to $2.34 billion in 2029 at a compound annual growth rate (CAGR) of 15.5%. The growth in the forecast period can be attributed to the increasing demand for personalized medicine, growing adoption of single-use platforms, rising investments in biologics manufacturing capacity, expansion of contract development and manufacturing organizations, and increasing regulatory support for single-use systems. Major trends expected during the forecast period include technological advancements in membrane surface chemistries, innovations in mixed-mode membrane adsorbers, developments in scalable and modular single-use platforms, research and development in ligand design and affinity membranes, and the integration of process analytical technology and automation.

The increasing adoption of personalized medicine is expected to drive the growth of the single-use chromatography membrane market in the coming years. Personalized medicine involves tailoring medical treatment to an individual’s genetic, molecular, and clinical characteristics for more accurate and effective care. The rise in personalized medicine is attributed to advancements in genomics that enable the development of therapies customized to a patient’s genetic profile, resulting in improved efficacy and safety. Single-use chromatography membranes support personalized medicine by providing faster, flexible, and contamination-free purification of patient-specific biologics, such as customized cell or gene therapies, thereby enhancing the efficiency and safety of individualized treatments. For example, in February 2024, according to the Personalized Medicine Coalition, a US-based non-profit organization, the FDA approved 16 new personalized therapies for rare disease patients in 2023, up from six in 2022. These newly approved treatments also included seven cancer drugs and three for other diseases and conditions. Hence, the growing prevalence of personalized medicine is contributing to the expansion of the single-use chromatography membrane market.

Major companies in the single-use chromatography membrane market are focusing on developing advanced technologies, such as mRNA purification, to improve process efficiency, product yield, and therapeutic quality. mRNA purification involves isolating messenger RNA (mRNA) molecules from mixtures of cellular components or reaction products to obtain high-purity mRNA suitable for therapeutic, vaccine, or research applications. For instance, in December 2024, Repligen Corporation, a US-based life sciences company, introduced AVIPure dsRNA Clear OPUS Columns to simplify and accelerate dsRNA purification for biopharmaceutical manufacturing. This technology provides a rapid and efficient method to eliminate double-stranded RNA impurities from mRNA therapeutics in just one minute, improving drug purity and minimizing immune responses. The single-use, pre-packed chromatography system removes the need for heat or solvents, streamlines workflows, and supports scalable production. It plays a vital role in ensuring high-quality, safe, and cost-effective mRNA vaccines and therapeutics through seamless integration into biomanufacturing operations.

In February 2023, Biotage AB, a Sweden-based life sciences company, acquired Astrea Bioseparations Ltd. for an undisclosed amount. The acquisition aimed to strengthen Biotage’s chromatography portfolio within the expanding bioprocessing sector, broaden its capabilities in biologics and advanced therapeutics, and position the company as a global leader in chromatography solutions with an enhanced pipeline and stronger financial foundation. Astrea Bioseparations Ltd. is a UK-based biotechnology company specializing in single-use chromatography membranes.

Major players in the single-use chromatography membrane market are Thermo Fisher Scientific Inc., 3M Company, Danaher Corporation, Merck KGaA, Solventum, Cytiva Life Sciences, W. L. Gore and Associates GORE Membrane Technologies, Sartorius Aktiengesellschaft, AGC Biologics GmbH, Repligen Corporation, GVS Group, i3 Membrane Inc., Cole-Parmer Instrument Company LLC, Restek Corporation, Cobetter Filtration Equipment Company Limited, Membrane Solutions LLC, Izon Science Limited, Sartorius Stedim Biotech S.A., BIA Separations Inc., NATRIX Separations Inc., and Purilogics.

North America was the largest region in the single-use chromatography membrane market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in single-use chromatography membrane report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The sudden escalation of U.S. tariffs and the consequent trade frictions in spring 2025 are severely impacting the pharmaceutical companies contend with tariffs on APIs, glass vials, and lab equipment inputs with few alternative sources. Generic drug makers, operating on razor-thin margins, are especially vulnerable, with some reducing production of low-profit medicines. Biotech firms face delays in clinical trials due to tariff-related shortages of specialized reagents. In response, the industry is expanding API production in India and Europe, increasing inventory stockpiles, and pushing for trade exemptions for essential medicines.

The single-use chromatography membrane market research report is one of a series of new reports that provides single-use chromatography membrane market statistics, including single-use chromatography membrane industry global market size, regional shares, competitors with a single-use chromatography membrane market share, detailed single-use chromatography membrane market segments, market trends and opportunities, and any further data you may need to thrive in the single-use chromatography membrane industry. This single-use chromatography membrane market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

A single-use chromatography membrane is a disposable filtration device utilized in bioprocessing and laboratory applications for the efficient separation and purification of biomolecules. Unlike conventional reusable chromatography columns, these membranes are intended for one-time use, removing the need for cleaning or sterilization, minimizing the risk of contamination, and enhancing process efficiency.

The main product types of single-use chromatography membranes include membrane adsorbers, capsules or cartridges, filter plates, and others. Membrane adsorbers are porous membranes that are functionalized with specific ligands, enabling selective adsorption and rapid purification of biomolecules in bioprocessing operations. The primary techniques employed include ion exchange, affinity, hydrophobic interaction, and others. These membranes are extensively used in applications such as biopharmaceutical production, vaccine manufacturing, and research and development, serving end-users such as pharmaceutical and biotechnology companies, academic institutions, and research organizations.

The countries covered in the single-use chromatography membrane market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The single-use chromatography membrane market consists of sales of single-use membrane systems, pre-assembled systems, and specialty membrane modules. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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