Long-Read Sequencing Market Report 2025

The long-read sequencing market size has grown exponentially in recent years. It will grow from $0.91 billion in 2024 to $1.15 billion in 2025 at a compound annual growth rate (CAGR) of 26.9%. The growth in the historic period can be attributed to rising demand for high-throughput genomic analysis, increasing adoption in academic research, expanding use in structural variant detection, growth in government-supported genome projects, and wider applications in plant and animal genomics.

The long-read sequencing market size is expected to see exponential growth in the next few years. It will grow to $2.96 billion in 2029 at a compound annual growth rate (CAGR) of 26.6%. The growth in the forecast period can be attributed to increasing use in precision medicine, rising investments in genomic infrastructure, growing adoption in clinical diagnostics, expansion of long-read sequencing in rare disease studies, and rising demand for comprehensive epigenetic profiling. Major trends in the forecast period include advancements in sequencing chemistry, integration of AI-driven data analytics, innovation in portable sequencing devices, development of cost-effective consumables, and progress in multi-omics workflow solutions.

The growing prevalence of genetic diseases is expected to drive the expansion of the long-read sequencing market. Genetic diseases are caused by mutations or changes in DNA, which may be inherited or occur spontaneously, affecting various aspects of health, development, and bodily functions. The increasing prevalence of these conditions can be attributed to heightened awareness and advancements in diagnostic technologies, which allow for earlier and more precise detection of previously undiagnosed diseases. Long-read sequencing plays a crucial role in managing genetic disorders by providing highly accurate and comprehensive genomic data, making it essential for diagnosing complex and rare conditions. It reduces diagnostic uncertainty by detecting structural variations and intricate mutations, thus enhancing personalized treatment approaches and clinical decision-making. For example, the Cystic Fibrosis Trust reported that in 2022, there were 11,148 patients diagnosed with cystic fibrosis, an increase from 10,908 cases in 2021. As such, the rising prevalence of genetic disorders is fueling the growth of the long-read sequencing market.

Leading companies in the long-read sequencing market are focusing on developing innovative solutions such as HiFi reads to improve sequencing accuracy, detect complex genetic variations, and accelerate genomic research. High-fidelity (HiFi) reads are long DNA sequences generated by advanced long-read sequencing technologies, offering both extended read lengths and extremely low error rates. This enables accurate detection of complex genetic variants and structural variations. For instance, in November 2024, Pacific Biosciences of California Inc. launched the Vega system, its first benchtop long-read sequencing platform. The Vega system provides highly accurate HiFi data with 99.9% read accuracy and enables faster, more accessible genomic analysis. This compact, affordable sequencer supports applications such as RNA sequencing, targeted sequencing, and small genome sequencing, bringing advanced genomics capabilities to more laboratories. The system simplifies workflows with onboard computing and user-friendly operation, helping researchers efficiently unlock complex genetic insights.

In February 2022, Element Biosciences Inc. acquired Loop Genomics Inc., a US-based biotechnology company specializing in long-read sequencing solutions, to enhance its genomic capabilities. Through this acquisition, Element integrated Loop's synthetic long-read technology into its AVITI platform, expanding its applications across research, clinical, and applied markets.

Major players in the long-read sequencing market are Thermo Fisher Scientific Inc., Agilent Technologies Inc., Illumina Inc., Revvity Inc., Bio-Rad Laboratories Inc., BGI Genomics Co. Ltd., Novogene Co. Ltd., Takara Bio Inc., Oxford Nanopore Technologies plc, Pacific Biosciences of California Inc., New England Biolabs Inc., Roche Sequencing Solutions Inc., The Garvan Institute, MGI Tech Co. Ltd., Element Biosciences Inc., Eurofins Genomics, CD Genomics, BaseClear B.V, France Génomique, GrandOmics Biosciences Co. Ltd., Future Genomics Technologies B.V., and MicrobesNG.

North America was the largest region in the long-read sequencing market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in long-read sequencing report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the long-read sequencing market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report’s Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.

The fast surge in U.S. tariffs and the trade tensions that followed in spring 2025 are heavily affecting the medical equipment sector, particularly for imported imaging machine components, surgical-grade stainless steel, and plastic disposables. Hospitals and clinics resist price hikes, pressuring manufacturers’ margins. Regulatory hurdles compound the problem, as tariff-related supplier changes often require re-certification of devices, delaying time-to-market. Companies are mitigating risks by dual-sourcing critical parts, expanding domestic production of commoditized items, and accelerating R&D in cost-efficient materials.

Long-read sequencing refers to a deoxyribonucleic acid or ribonucleic acid sequencing method that produces relatively long continuous reads of nucleic acids, often ranging from thousands to millions of base pairs, compared to short-read techniques. It allows for more precise genome assembly, identification of structural variations, and analysis of complex genomic regions.

The main product and service categories of long-read sequencing are instruments or platforms, consumables and reagents, and services and software. Instruments or platforms refer to the sequencing devices and hardware used to conduct long-read sequencing. This includes workflows such as pre-sequencing, sequencing, and data analysis, and is supported by technology platforms including single molecule real-time (SMRT) high-fidelity (HiFi) sequencing, nanopore sequencing, synthetic long-read or linked-read, hybrid, and others. It is applied in human genomics and rare-disease diagnostics, oncology and liquid biopsy, metagenomics and microbiome, transcriptomics, agri-genomics and plant or animal breeding, and others, serving end users such as academic and research institutes, hospitals and clinics, pharmaceutical and biotechnology companies, and others.

The long-read sequencing market research report is one of a series of new reports that provides long-read sequencing market statistics, including long-read sequencing industry global market size, regional shares, competitors with a long-read sequencing market share, detailed long-read sequencing market segments, market trends and opportunities, and any further data you may need to thrive in the long-read sequencing industry. This long-read sequencing market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The long-read sequencing market consists of revenues earned by entities by providing services such as high-throughput DNA sequencing, real-time genome analysis, structural variant detection, and de novo genome assembly. The market value includes the value of related goods sold by the service provider or included within the service offering. The long-read sequencing market also includes sales of library preparation kits, analysis tools, and library and sample prep kits. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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