NEXT-GENERATION RNA THERAPEUTICS MARKET: GROWTH AND TRENDS
Due to its critical role in protein production and gene function regulation in the human body, RNA is being explored as a possible therapeutic option. Researchers are recognizing the immense possibilities linked to RNA-based therapies, as they can precisely target and address conditions that were previously considered incurable. Nonetheless, the extremely volatile characteristics of these molecules pose considerable challenges to their use as therapeutic alternatives. In recent years, the emergence of advanced technologies and platforms has enhanced the interest of industry stakeholders in improved and altered RNA-based therapies, which are thought to be very stable and offer prolonged effects at relatively low doses. This category of modified RNA-based treatments is referred to as next generation therapies. The growing pipeline of RNA-based treatment modalities and favourable clinical trial results have encouraged several big pharma players to undertake initiatives for the development and advancement of these RNA therapeutics / vaccines.Owing to the research and development efforts, substantial investment activity and increased participation of prominent players, the RNA therapeutics and vaccines market is anticipated to witness significant growth in the foreseen future.
NEXT-GENERATION RNA THERAPEUTICS MARKET: KEY INSIGHTS
The report delves into the current state of the next generation RNA therapeutics market identifies potential growth opportunities within the industry. Some key findings from the report include:
- More than 100 next generation RNA therapeutics and vaccines are being developed to offer an advanced, low-dose form of treatment, targeting a wide range of therapeutic indications.
- 75% of the next generation therapies are still in discovery and preclinical stages, primarily targeting infectious diseases; industry players are actively engaged in advancing their next generation drug portfolio.
- Over 35 next generation RNA technologies are being developed / offered by companies for the research, discovery, design, development, manufacturing and delivery of novel RNA therapies and vaccines.
- Around 55% of the technologies are used in the development of circular RNA-based therapeutics and vaccines; majority of such technologies facilitate targeted therapy delivery at a specific site within the cell.
- Majority of the trials focused on RNA therapeutics and vaccines were registered in 2022; more than 70% of these studies have either been completed / are currently recruiting patients across different locations.
- Close to 1,170 patents have been filed / granted for next generation RNA therapeutics and vaccines, by industry and non-industry players, to protect intellectual property generated within this field.
- Around 70% of the deals inked in this market were focused on clinical research of saRNA therapeutics / vaccines; of these, more than 60% partnerships were inked for the treatment of infectious diseases.
- Several investors, having realized the opportunity within this domain, have invested close to USD 2.9 billion across various funding rounds in the past four years.
- The rising interest of big pharma players is reflected by the increase in the number of next generation RNA therapeutics / vaccines-focused initiatives, including partnerships and funding, undertaken in recent years.
- The market opportunity associated with next generation RNA therapeutics and vaccines is expected to witness an annualized growth rate of 68% between 2028 to 2035.
NEXT GENERATION RNA THERAPEUTICS MARKET
Vaccines Account for the Highest Share of the Next Generation RNA Therapeutics Market
Based on the type of modality, the market is segmented into RNA therapeutics and RNA vaccines. At present, RNA vaccines capture a substantial proportion of the next generation RNA therapeutics market. This trend is unlikely to change in the near future.Replicating RNA Dominates the Next Generation RNA Therapeutics Market During the Forecast Period
Based on the type of molecule, the market is segmented into replicating RNA, self amplifying RNA, self activating RNA, self amplifying mRNA and transfer RNA. At present, replicating RNA holds the maximum share of the next generation RNA therapeutics market. However, self amplifying RNA is likely to drive the market in the near future.Infectious Diseases Segment Captures the Highest Share of the Next Generation RNA Therapeutics Market
Based on the therapeutic area, the market is segmented into infectious diseases and oncological disorders. Currently, infectious diseases account for the 100% share of the next generation RNA therapeutics market. However, oncological disorders segment is likely to drive the market in the near future.Intradermal Route Occupies for the Largest Share of the Next Generation RNA Therapeutics Market
Based on the route of administration, the market is segmented into intradermal, intramuscular and intravenous. Currently, intradermal route holds the majority share of the next generation RNA therapeutics market. However, intramuscular route is likely to drive the market in the near future.Asia-Pacific Accounts for the Largest Share of the Market
Based on key geographical regions, the market is segmented into North America and Asia-Pacific. The majority of the share is expected to be captured by drug developers based in Asia-Pacific. It is worth highlighting that, over the years, the market in North America is expected to grow at a higher CAGR.Example Players in the Next Generation RNA Therapeutics Market
- Alphavax
- Arcturus Therapeutics
- Atyr Pharma
- Gritstone Bio
- HDT Bio
- MiNA Therapeutics
- VLP Therapeutics
NEXT GENERATION RNA THERAPEUTICS MARKET: RESEARCH COVERAGE
- Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the next generation RNA therapeutics market, focusing on key market segments, including [A] type of modality, [B] type of molecule, [C] therapeutic areas, [D] route of administration [E] and [F] key geographical regions.
- Market Landscape: A comprehensive evaluation of next generation RNA therapeutics that are either approved or being evaluated in different stages of development, considering various parameters, such as [A] type of modality, [B] type of molecule, [C] type of delivery vehicle, [D] phase of development [E] therapeutic area and [F] key niche market segments (circRNA and saRNA). Additionally, the chapter includes analysis of various next generation RNA therapeutic and RNA vaccine developers, based on their [G] year of establishment, [H] company size, [I] location of headquarters and [J] most active players (in terms of number of therapies).
- Technology Landscape: A comprehensive evaluation of technologies that are being developed / deployed to support the development of next generation RNA therapeutics, considering various parameters, such as [A] class of molecule, [B] type of molecule, [C] capabilities of the technology, [D] therapeutic area and [E] highest phase of development. Additionally, the chapter features analysis of various next generation RNA therapeutic and RNA vaccine technology developers, based on their [F] year of establishment, [G] company size, [H] location of headquarters and [I] operational model.
- Drug Profiles: In-depth profiles of drug candidates that are in advanced stages of development, focusing on [A] details on its developer, [B] drug overview, [C] clinical trial information, [D] clinical trial endpoints, [E] clinical trial results and [F] estimated sales.
- Clinical Trial Analysis: Examination of completed, ongoing, and planned clinical studies of various next generation RNA therapeutics, based on parameters like [A] trial registration year, [B] trial status, [C] trial phase, [D] patients enrolled, [E] type of sponsor, [F] therapeutic area, [G] study design, [H] leading organizations (in terms of number of trials), [I] focus area and [J] geography.
- Patent Analysis: Detailed analysis of various patents filed / granted related to next generation RNA therapeutics based on [A] type of patent (granted patents, patent applications and others), [B] patent publication year, [C] patent jurisdiction, [D] CPC symbols, [E] emerging focus areas, [F] patent age, [G] leading industry / non-industry players (in terms of number of patents filed / granted) and [H] patent valuation.
- Partnerships and Collaborations: An analysis of partnerships established in this sector based on several relevant parameters, such as the [A] year of partnership, [B] type of partnership, [C] type of molecule, [D] focus of partnership, [E] purpose of partnership, [F] therapeutic area, [G] most active players (in terms of number of partnerships) and [H] the regional distribution of partnership activity in this market.
- Funding and Investment Analysis: A detailed evaluation of the investments made in this domain based on several relevant parameters, such as [A] year of funding, [B] type of funding, [C] type of molecule, [D] amount invested, [E] geography, [F] purpose of funding, [G] stage of development, [H] therapeutic area, [I] most active players (in terms of number and amount of funding instances) and [J] leading investors (in terms of number of funding instances).
- Big Pharma Analysis: A comprehensive examination of various initiatives focused on next generation RNA therapeutics undertaken by major pharmaceutical companies based on several relevant parameters, such as [A] number of initiatives, [B] year of initiative, [C] type of initiative, [D] purpose of initiative, [E] focus of initiative and [F] location of headquarters.
KEY QUESTIONS ANSWERED IN THIS REPORT
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What kind of partnership models are commonly adopted by industry stakeholders?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
REASONS TO BUY THIS REPORT
- The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
- Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
- The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.
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Table of Contents
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- 4SR Biosciences
- 8VC
- Alexandria Real Estate Equities
- Alltrna
- AlphaVax
- aMoon
- Apple Tree Partners
- Arcturus Therapeutics
- Aspire Capital
- AstraZeneca
- Atlas Special Opportunities
- aTyr Pharma
- Aurora Vaccines
- Avidity Partners
- AyurMaya Capital Management Fund
- BeiGene
- MPM BioImpact
- BioNTech
- Camford Capital
- Catalent
- Charles River
- Chimerna Therapeutics
- Chimeron Bio
- Circio
- Circularis
- Coalition for Epidemic Preparedness Innovations (CEPI)
- Colt Ventures
- Cowen Healthcare Investments
- Creative Biolabs
- CSL Behring
- CSL Seqirus
- CureVac
- Curia
- Dualsystems Biotech
- Duke-NUS Medical School
- EcoR1 Capital
- Eli Lilly
- Elixirgen Therapeutics
- Epidarex
- Esperovax
- F2 Ventures
- Flagship Pioneering
- FPV Ventures
- Frazier Life Sciences
- Friends of FSH Research
- FUJIFILM
- FUJIFILM Diosynth Biotechnologies
- Genevant Sciences
- George Mason University
- Gilead Sciences
- Ginkgo Bioworks
- GlaxoSmithKline
- Gritstone bio
- hC Bioscience
- HDT Bio
- Hercules Capital
- ImmunityBio
- Imperial College London
- Israeli Ministry of Health
- Japanese Ministry of Economy, Trade and Industry (METI)
- K2 HealthVentures
- Konishiyasu
- KYORIN Pharmaceutical
- Laronde
- Leaps by Bayer
- Levatio Therapeutics
- Maryland Industrial Partnerships
- thisMerck
- Michigan Rise
- MiNA Therapeutics
- miRecule
- Miyako Capital
- MPM Capital
- MSA Capital
- MUFG Bank
- National Cancer Institute (NCI)
- National Institutes of Health
- Nobelpharma
- Oncorus
- OrbiMed
- Orbital Therapeutics
- Orna Therapeutics
- Pan African Cancer Research Institute (PACRI)
- Panacea Venture
- Perceptive Advisors
- Pfizer
- Playground Global
- Precision NanoSystems
- Quanchuang Capital
- Recipharm
- ReCode Therapeutics
- Redmile Group
- Replicate Bioscience
- Ring Code Biotech
- Sanofi
- Servier
- ShapeTX
- Silicon Valley Bank
- Simnova
- SK Impact Fund
- Sojitz
- Solve FSHD
- Strand Therapeutics
- SYTE.bio
- Taiho Ventures
- Takeda Ventures
- Tevard Biosciences
- Biomedical Advanced Research and Development Authority (BARDA)
- Coalition for Epidemic Preparedness Innovations (CEPI)
- National Institute of Allergy and Infectious Diseases
- The National University Cancer Institute, Singapore (NCIS)
- University of Nebraska Medical Center
- The University of Texas Medical Branch (UTMB)
- Therorna
- Transine Therapeutics
- TriLink BioTechnologies
- University of Antwerp
- UZ Gent
- VaxEquity
- Vertex Pharmaceuticals
- Vida Ventures
- Vingroup
- VLP Therapeutics
- Ziphius Vaccines
- Zogenix (Acquired by UCB)
- Zoic Capital
Methodology

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