Emerging Trends in Phytotherapy of Cancer is an essential reference that explores the multifaceted role of medicinal plants in combating cancer. The book covers a broad range of interconnected topics including ethnomedicinal plants used in cancer by tribes and aboriginals, herbs used in Ayurvedic medicine for cancer, integrated approaches of modern and conventional drugs, anti-cancerous secondary metabolites, plant-based anticancer drugs approved by FDA and WHO, toxicity to humans, and the role of emerging technologies such as the applications of nanotechnology and artificial intelligence. The contents are divided into six parts. Part one opens with an introductory chapter, followed by the different combinations of plant-based drugs and modern medicine for cancer treatment, and recent developments in cancer research. Part two discusses the ethnomedicinal uses of plants in cancer and the role of Ayurvedic herbal medicines in cancer. Part three incorporates the role of secondary metabolites in cancer treatment. Part four elaborates on the plant-based drugs recommended by FDA/WHO. Part five concerns the human phytotoxicity of secondary metabolites, and part six describes the role of emerging nanotechnologies and artificial intelligence in phytotherapy drug delivery and treatment. Targeted at researchers, healthcare professionals, and advanced students in related fields, this book provides technical and in-depth knowledge, contributing to ongoing advancements in cancer treatment. It uniquely integrates ethnomedicinal therapies with modern technologies, offering a comprehensive overview of the research into phytomedicinal cancer therapies.
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Table of Contents
Section 1: Introduction to Phytotherapy for Cancer and Its Prevention1. Introduction to Phytotherapy in Cancer Treatment
2. Interaction between plant-based drugs and modern medicine used for cancer: Efficacy and side effects
3. Recent Developments in Bioactive Compounds for Cancer Treatment
Section 2: Ethnomedicinal Uses of Plants in Cancer Treatment
4. Ethnomedicinal Plants Used in Cancer Treatment
5. Ayurvedic Herbs in Oncological Care: Traditional Wisdom Meets Modern Science
6. Combining Ethnomedicine with Conventional Cancer Therapies
Section 3: Role of Secondary Metabolites in Cancer Treatment
7. Alkaloids as novel therapeutic agents in Cancer Treatment
8. Flavonoids in Cancer Treatment: Structures, Mechanisms, and Future Directions
9. Phytocannabinoids as Bioassay Targets in Anticancer Chemotherapy
10. Terpenoids and Phenolics as Anticancer Agents
11. Glycosides in Cancer Treatment
12. Role of Saponins in Cancer Treatment
13. Impact of Phytochemicals on Cancer: A Nutrigenomics and Nutrigenetics Perspective
14. Techniques of extraction of medicinal plants, quality assessment reproducibility
15. Synergistic Effects of Secondary Metabolites in Cancer Treatment
Section 4: Plant-Based Drugs for Cancer Recommended by FDA/WHO
16. FDA-Approved Plant-Based Drugs for Cancer Treatment
17. WHO-Recommended Plant-Based Therapies for Cancer
18. Case Studies of Notable Plant-Based Drugs (Paclitaxel, Vincristine, Camptothecin Derivatives, Etoposide)
19. Clinical Applications and Advancements in Camptothecin-Based Cancer Therapies
Section 5: Phytotoxicity of Secondary Metabolites and Essential Oils
20. Toxicity of Key Secondary Metabolites and Essential Oils
21. Regulatory and Ethical Considerations in Phytotoxicity of plant-based drugs used in Cancer
Section 6: Nanotechnology and AI Applications in Medicinal Plants Used in Cancer
22. Ayurvedic Medicinal Plants-Based Carbon Dots for Imaging Cancer Cells and Conducting Phototherapy
23. Designing Nanocomposites Using Bioactive Metabolites Derived from Medicinal and Aromatic Plants to Combat Cancer
24. Nanotechnology-Based Drug Delivery of Natural Products in Cancer
25. Targeting triple-negative breast cancer signaling via phytonanomedicine
26. Artificial Intelligence-Guided Discovery of Anticancer Lead Compounds from Plants
27. Emerging Machine Learning Techniques for the Development and Analysis of Anticancer Drugs from Plants
Authors
Mahendra Rai UGC-Basic Science Research Faculty Fellow and former Head of the Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India.Mahendra Rai is an internationally recognized scholar with extensive contributions to microbial biotechnology and nanobiotechnology research, particularly in the green synthesis of metal nanoparticles using fungi and their application as nano-antimicrobials. His work is highly interdisciplinary, bridging microbiology, biotechnology, and nanoscience, and he is an active member of several scientific societies. He has received multiple national and international distinctions, including the Father T.A. Mathias Award from the All-India Association for Christian Higher Education and the Medini Award from the Government of India. Professor Rai has also held numerous visiting scientist and visiting professor positions across Europe, South America, and Asia, contributing to long-standing research collaborations in countries such as Brazil, Argentina, Hungary, Switzerland, Italy, Germany, and the United States. His sustained academic impact is reflected in his inclusion among the global top 2% of scientists in nanoscience and nanotechnology, and recognition as one of India's leading researchers in biology and biochemistry, including a Biology and Biochemistry India Leader Award from Research.com.
Shandesh Bhattarai Nepal Academy of Science and Technology, Nepal.Dr. Shandesh Bhattarai is a Research Scientist at the Nepal Academy of Science and Technology (NAST), Nepal. He is a dedicated researcher with over thirteen years of postdoctoral experience in plant science, in addition to seven years of prior research in the same field. He also has two years of university-level teaching experience.
Dr. Bhattarai is widely published in reputed plant science journals and brings expertise in applied ethnobotany, ethnopharmacology, plant systematics, plant taxonomy, bioassays, invasive alien plant species, and biodiversity conservation. His work emphasizes the integration of traditional knowledge with modern scientific approaches.
