Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.
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Table of Contents
1 Aging: Concept, theories, principle and future prospective2 Overview of hallmarks of aging
3 Reverse aging: Concept, significance, theories and future prospective
4 Reprogramming a cell’s epigenetic status for reverse aging
5 Cellular reprogramming for reverse aging
6 NANOG: A key element for reverse aging
7 Reduction of IGF-1/PKA to promote hematopoietic-stem cell-based reverse aging
8 Rejuvenating stem cells to reverse aging
9 Histone modification (H3K27) to reverse aging
10 Autophagy as a therapeutic target to enhance reverse aging
11 mRNA enhanced cell therapy and reverse aging
12 Reverse aging through immune driven signaling
13 Mitochondrial modulations for reverse aging
14 Reverse aging through cell cycle regulation
15 Metabolic reprogramming for reverse aging
16 Diets, phytochemicals, drugs, and nutraceuticals for reverse aging
17 Artificial intelligence and antiaging research
18 Reverse aging through redox-sensitive transcription factors modulation
Authors
Sandeep Kumar Singh Department of Medical Biotechnology, All India Institute of Medical Sciences, Nagpur, MH, India.Dr. Sandeep Kumar Singh is Assistant Professor in the All India Institute of Medical Sciences (AIIMS), Nagpur, India. He obtained his PhD in Biotechnology from Banaras Hindu University and conducted postdoctoral research in the Department of Neurobiology at the University of Chicago. Dr. Singh brings 17 years of experience in neuroscience, molecular biology, neurodegenerative diseases, aging, nutraceuticals, and nanomedicines. He is a member of several scientific societies, including the American Academy of Neurology, International Society of Neurochemistry, Society of Neurochemistry, Indian Academy of Neurosciences, and Alzheimer's and related Disorders Society of India. Dr. Singh has published five books, including Elsevier's A New Era in Alzheimer's Research and Genome Editing for Neurodegenerative Diseases.
Shailendra Kumar Mishra Indian Scientific Education and Technology Foundation, Lucknow, Uttar Pradesh, India. Shailendra Kumar Mishra is co-founder of Indian Scientific Education and Technology (ISET) Foundation, a non-profit/non-governmental organization that persuades toward the science promotion. He is Molecular Human Genetics postgraduate, skilled in DNA Sequencing, Polymerase Chain Reaction (PCR), DNA & Plasmid isolation, Gel electrophoresis, Molecular hybridization, DNA elution from agarose gel, bacterial transformation, quantitation of DNA, DNA sequencing technique and versed in various diagnostic techniques. He did Master of Science in Molecular and Human Genetics from Jiwaji University, India, and research project from Banaras Hindu University, India. He has published his articles in some international and national journals such as Journal of Alzheimer's Disease and Parkinsonism and Nature India. His major interest is to understand the aging process through molecular basis that could be beneficial to cure age-related diseases.
