Antimicrobial Therapeutics and Drug Discovery. Drug Discovery Opinions

Table of Contents

Part I: Antiviral Drug Discovery
1. Exploring Viral and Host Targets for Antiviral Drug Discovery
2. COVID-19 Challenges and its Therapeutics
3. From Lab to Clinic: The Evolution of Reverse Transcriptase Inhibitors in HIV Treatment
4. Targeting Hepatitis C Virus Polymerase: Non-Nucleoside Inhibitors (NNIs) and Drug Resistance
5. Challenges, Progress, and Prospects of Drug Discovery to Treat Chronic Hepatitis B (CHB) Infection
6. Discovery and Development of Antiviral Therapies for Influenza Virus Infections
7. Medicinal Chemistry Strategies for the Discovery and Development of Anti-Herpesvirus Drugs
8. Opportunities and Challenges in Targeted Protein Degradation for Antiviral Drug Discovery

Part II: Antibacterial Drug Discovery
9. Molecular Mechanisms of Antibiotic Resistance
10. Overview of the Antibiotics Approved in the Last Two Decades: Retrospect and Prospect
11. Antibiotic Resistance Breakers: Current Approaches and Future Directions
12. Innovative Approaches in Developing Antimicrobial Peptides for Drug-Resistant Bacterial Infections
13. The Potential of Antibody-Antibiotic Conjugates in Combatting Bacterial Diseases
14. Phage Therapy: Current Advancements and Future Prospects in Combating Antimicrobial Resistance

Part III: Drug Discovery for Miscellaneous Pathogens
15. Antifungal Drug Resistance: Current Mechanisms and Future Directions
16. Challenges, Unmet Clinical Needs, and Novel Approaches in the Discovery of Antifungal Drugs
17. Drug Discovery against Mycobacteria: The Success and Challenges
18. Future of Drug Development for the Treatment of Mycoplasma Infections
19. Antimalarial Drug Discovery: From Novel Molecules to Clinical Development

Part IV: Next-Generation Antimicrobial Strategies
20. Computational Approaches in Antimicrobial Drug Discovery
21. Multi-Omics Approaches for Antimicrobial Drug Discovery
22. Nanomedicine as a Next-Generation Antimicrobial Therapy: New Frontiers in Fighting Microbial Infections
23. Drug Repurposing: Innovative Antimicrobial Strategies to Combat Resistance
24. Drug Combinations: A Strategy to Extend the Life of Antimicrobials
25. Ethical Imperatives in Combating Antimicrobial Resistance: A Global Perspective

Authors

Chengyuan Liang School of Biological and Pharmaceutical Sciences, Shaanxi University of Science and Technology. Dr. Chengyuan Liang is a Professor at the School of Biological and Pharmaceutical Sciences, Shaanxi University of Science and Technology. He also serves as Director of the Xi'an Key Laboratory for Antiviral and Antimicrobial-Resistant Bacteria Therapeutics Research, the Research Center for the Development of Therapeutic Drugs for Serious Infectious Diseases in Shaanxi Province's Universities and Colleges, and the Xi'an International Science and Technology Cooperation Base for Anti-Infective Drug Research and Development. His research focuses on medicinal chemistry and translational drug development, including small-molecule antivirals and antibacterials, inhibitors, PROTACs, and antibody-drug conjugates. His work also includes mechanism studies, veterinary drugs, bioequivalence evaluation, natural product modification, and the modernization of classical Chinese medicine through process optimization and quality standards. Lei Tian School of Biological and Pharmaceutical Sciences, Shaanxi University of Science and Technology. Dr. Lei Tian is a Lecturer at the School of Biological and Pharmaceutical Sciences, Shaanxi University of Science and Technology. She is affiliated with the Engineering Research Center of Major Infectious Disease Therapeutics at Universities of Shaanxi Province and the Xi'an Key Laboratory of Antiviral and Antimicrobial-Resistant Bacteria Therapeutics Research. Her research focuses on medicinal chemistry and anti-infective drug discovery, including targeted protein degradation strategies for pathogenic microorganisms and the development of therapeutics against coronaviruses and multidrug-resistant bacteria. Her work also includes the discovery and optimization of bioactive molecules through chemical synthesis, biological evaluation, pharmacological characterization, mechanism-of-action studies, and preclinical drug development.