Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways: Synergistic Approaches in Gastrointestinal Cancer Treatment provides a comprehensive exploration of the complex mechanisms underlying gastrointestinal (GI) cancers, including colorectal, gastric, liver, and pancreatic malignancies. The book addresses the urgent need for innovative therapeutic strategies by synthesizing current research on DNA repair, tumor genetics, and cellular signaling pathways critical to cancer progression and treatment. It examines the roles of DNA repair mechanisms and the influence of genetic factors on personalized medicine while also discussing the potential of combining targeted therapies to enhance treatment efficacy.
Featuring real-world case studies and insights from leading experts, the book bridges the gap between basic research and clinical application. For an academic audience, this resource promotes a holistic understanding of GI cancer biology, addresses treatment resistance, and fosters collaboration among researchers and clinicians, ultimately improving patient outcomes in this rapidly evolving field.
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Table of Contents
1. Introduction to Gastrointestinal Cancers: An Overview of Current Challenges2. Understanding DNA Repair Mechanisms: The Key Players in Genomic Stability
3. The Genetic Landscape of Gastrointestinal Tumors: Key Alterations and Pathways
4. The Role of Signaling Pathways in Tumorigenesis
5. The Role of DNA Damage Response in Cancer Progression
6. Synergistic Approaches in GI Cancer Therapy: Concepts and Strategies
7. Targeting DNA Repair and Signaling Pathways: A Novel Paradigm in Gastrointestinal Cancer Treatment
8. Inhibiting Homologous Recombination: Therapeutic Implications in GI Cancers
9. The Role of PARP Inhibitors in Enhancing Chemotherapy Efficacy
10. Exploiting the Synthetic Lethality Concept in Gastrointestinal Tumors
11. Combination Therapies: Chemotherapy and DNA Repair Inhibition in GI Cancers
12. Immunotherapy and DNA Repair: A Dual Approach to Combat GI Cancers
13. Radiation Therapy: Targeting DNA Repair Mechanisms for Enhanced Outcomes
14. Emerging Biomarkers: Predicting Response to DNA Repair and Signaling Targeting Therapies
15. Clinical Trials: Evidence for Synergistic Approaches in GI Cancer Treatment
16. Future Directions: Novel Targets and Strategies in DNA Repair, Signaling for GI Cancers
17. Integrating Genomics with Immunotherapy for GI Cancers: A Synergistic Approach
18. Conclusion: Integrating Synergistic Approaches for Personalized GI Cancer Treatment
Authors
Ganji Purnachandra Nagaraju Assistant Professor, School of Medicine, Division of Hematology and Oncology, University of Alabama, Birmingham, AL, USA. Dr. Nagaraju obtained his MSc and his PhD, both in Biotechnology, from Sri Venkateswara University in Tirupati, Andhra Pradesh, India. He received his DSc from Berhampur University in Berhampur, Odisha, India. Dr. Nagaraju's research focuses on translational projects related to gastrointestinal malignancies. He has published over 100 research papers in highly reputed international journals and has presented more than 50 abstracts at various national and international conferences. Dr. Nagaraju is author and editor of several published books for Elsevier and Springer Nature. He serves as editorial board member of several internationally recognized academic journals. Dr. Nagaraju has received several international awards including FAACC. He also holds memberships with the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), The Science Advisory Board, The RNA Society, The American Association for Clinical Chemistry (AACC) and the American Association of Cancer Research (AACR). Bassel F-El-Rayes O'Neal Cancer Center, USA.Bassel F. El-Rayes, M.D., is the deputy director of the UAB O'Neal Comprehensive Cancer Center, a senior scientist at the O'Neal Cancer Center, a professor of Medicine and the director of the Division of Hematology & Oncology in the UAB Department of Medicine. Dr. El-Rayes is focused translational research and drug development in gastrointestinal cancer with special emphasis on pancreatobiliary and neuroendocrine cancers. El-Rayes has served as principal investigator on several peer-reviewed NCI grants, investigator-initiated trials and multi-institutional trials. He has published more than 250 peer-reviewed scientific articles. He has served on several national committees, including the NCI Neuroendocrine Tumor Task Force and the National Committee of the American Society of Clinical Oncology for the development of guidelines for the management of central venous catheters in patients with cancer.
