Animal Models of Disease, Part E, Volume 203 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.
Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.
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Table of Contents
1. Establishment single lung tumors through orthotopic injection
Be�at Picabea, C�line Cl�menson, Mirari Echepare, Cristina Viu-Idocin, Ane �lava,
Estefan�a Rodr�guez, Michele Mondini, Karmele Valencia
2. Intracardiac injection as a metastatic model in lung cancerEstablishment single lung tumors through orthotopic injection
Mirari Echepare, Be�at Picabea, Cristina Viu-Idocin, Ane �lava, Estefan�a Rodr�guez,
Karmele Valencia
3. Adeno-associated viral vector administration to the inner ear and phenotype evaluation in a mouse model of hearing loss
Sergio Isola and Carmen Unzu
4. DiLiCre2.0 mouse model: An advanced genome-editing tool to induce mutagenesis in vivo with high spatio-temporal resolution
Miguel Vizosoa
5. A new inducible mouse model of FH loss
Vincent Zecchini, Chrysanthi Moschandrea, Farina Schneider, and Christian Frezza
6. Monitoring neuronal mitophagy and locomotion deficits in a C. elegans model of Alzheimer's disease
Giorgos Garcia Niforos, Eleni Tsakiri, and Konstantinos Palikaras
7. Experimental models and methods for infected wound modeling with Staphylococcus aureus
Estela P�rez, Guillermo Landa, Isabel Besc�s, Ignacio Ochoa, and Elena Tapia
8. Multiplex immunohistochemistry (IHC) profiling of murine tumour-infiltrating T cells
Erminia Romano, Caron Behan, Alexander Baker, Garry Ashton, and Jamie Honeychurch
9. Isolation of Regulatory T Cells from Healthy Murine Mammary Glands
D.Michael Mann, Hossein Ehsanbakhsh, and Paula D. Bos
10. Metastasis mouse model of breast cancer derived from Circulating Tumor Cells (CTCs) after primary orthotopic tumor resection.
Angela P�rez-Cervera, Haritz Moreno, Helena Villanueva, Angelina Zheleva, Beatriz Moreno, Fernando Lecanda, Fernando Pastor
11. Establishment of humanized patient-derived xenografts (PDXs) from primary human colorectal cancer tumors
Carmen Navarrete-Sirvent, Aurora Rivas-Crespo, Mar�a Teresa S�nchez-Montero,
Alejandra D�az-Chac�n, Regina Pe�a-Enr�quez, Enrique Aranda, Antonio Rodr�guez-Ariza, and Silvia Guil-Luna
Modeling stress-induced proteinopathies in Caenorhabditis elegans
Elena Caldero-Escudero and Silvia Romero-Sanz
Intravital imaging of mouse subcutaneous tumors placed in the ear for the study of immune cell interaction with blood vessels
Almudena Manzanal, Beatrice Pinci, Carlos Luri-Rey, Diana Alcobia, David Causap�, and
�lvaro Teijiera
Induction of allergic dermatitis with dinitrofluorobenzene in Yama mice
Yusuke Yamada-Satchwell, Kyoko Yoshizaki, Masashi Sakurai, and Masahiro Morimoto
