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The Psychedelic Brain. A Biobehavioral Evolutionary Approach to Psychedelics

  • Book

  • December 2026
  • Elsevier Science and Technology
  • ID: 6250883
The Psychedelic Brain: A Biobehavioral Evolutionary Approach to Psychedelics provides an up to date volume on the diverse effects that psychedelics have on the brain, experience, cognition, emotions, and treatment-resistant diseases. This volume provides biological and behavioral understandings of the significance of psychedelics across human evolution and their traditional and contemporary uses as therapies. The research presented offers interdisciplinary perspectives from neuropharmacology, clinical science, cross-cultural studies, and phenomenological research to provide readers with both classic and cutting-edge findings and a paradigmatic framework for future research into their mechanisms and applications.

Table of Contents

Part I: Psychedelics, Brain Networks, and the Selves
1. Introduction to the Psychedelic Brain: Updating the REBUS Model of Psychedelic Experiences
2. Psychedelic Effects on Sensory Networks and their Effects on Global Brain Networks
3. Psychedelic Action on Major Brain Networks
4. The Self Structures in Consciousness and Psychedelics

Part II: The Evolutionary Origins of the Psychedelic Brain
5. Psilocybin and the Environments of Evolved Adaptation
6. The Evolved Hominin Brain: Vision, Sociality and Symbols
7. The Evolution of Ritual Set and Setting

Part III: The Phenomenologies and Neurophenomenology of Psychedelic Experience
8. The Varieties of Psychedelic Experience
9. The Nature of Consciousness and Altered Consciousness
10. The Psychobiology of the Alteration of Consciousness
11. Psychedelics and Consciousness

Part IV: How Do Psychedelics Heal?
12. Shamanic Ritual Healing: ASC, Set and Setting
13. Entheogenic Healing Practices: Tradition and Survivals
14. The Evolved Psychology of Entheogenic Healing
15. Mechanisms of Psychedelic Healing: Multidisciplinary Perspectives

Part V: Theory and Philosophy of Knowledge of the Psychedelic Experience
16. A Psychedelic Epistemology and Neurophenomenology
17. The Meanings of Psychedelic Experiences and Healing

Authors

Michael James Winkelman Arizona State University, USA. Michael J. Winkelman (Ph.D. University of California-Irvine; M.P.H. from University of Arizona) is retired from Arizona State University. Winkelman served as President of the Anthropology of Consciousness and Anthropology of Religion Sections of the American Anthropological Association. Winkelman has engaged in cross-cultural and interdisciplinary research on shamanism, psychedelics, and the alteration of consciousness for 40 years.