Breathborne Biomarkers and the Human Volatilome. From Chemistry and Biology to Technology and Applications. Edition No. 3

Table of Contents

PART A:Concepts in breath analysis
1. Breath biomarkers and the exposome
2. Breath sampling and standardization
3. Physiological modelling of exhaled compounds

PART B: Breath constituents
4. Endogenous volatiles and the breath volatilome
5. Exhaled nitric oxide 6.Exhaled carbon monoxide
7. Exhaled breath condensate and aerosols

PART C: Analytics
8. Selected ion flow tube mass spectrometry
9. Proton transfer reaction-mass spectrometry
10. Ion mobility spectrometry
11. Secondary electrospray ionization
12. Sensor systems
13. Optical spectroscopy
14. Gas chromatography-mass spectrometry
15. High-resolution mass spectrometry

PART D: Breath tests
16. 13C breath tests
17. Breath monitoring in the intensive care unit
18. Chronic obstructive pulmonary disease, smoking and vaping
19. Clinical phenotyping 20.Breath analysis for respiratory infections
21. Volatile biomarkers of viral infections
22. Lifestyle applications

PART E: Beyond human breath
23. Biomarkers in urine and stool
24. Volatile emissions from skin
25. Mammalian bioreactors for volatile emissions
26. Yeast and fungal volatilome
27. Bacterial volatile emissions

PART F: Field applications
28. Breath analysis in law enforcement
29. Drugs in breath
30. Urban search and rescue
31. Breath analysis in constrained environments
32. Breath analysis in occupational medicine
33. Breath biomarkers in human xenobiotic exposure studies
34. Canine olfaction

PART G: Design and interpretation
35. Clinical study design
36. Challenges in clinical breath research development
37. Mathematical interpretation of targeted volatilome data
38. Preprocessing and analysis of volatilome data

Authors

Jonathan Beauchamp Manager, Emissions Analytics and Diagnostics group, Fraunhofer Institute for Process Engineering and Packaging IVV, Freising, Germany. Jonathan Beauchamp is manager of the Emissions Analytics and Diagnostics group at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany. He has been involved in academic and industrial breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an active member and current treasurer of the International Association of Breath Research (IABR). Cristina Davis Chair and Professor, Department of Mechanical and Aerospace Engineering, University of California, Davis, CA, USA. Cristina Davis is chair and professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research focuses on development of novel chemical and biological sensor systems and biomarker identification in agriculture and human/animal health monitoring. She has 12 issued patents and has coauthored over 100 peer-reviewed journal articles and book chapters. She is current chair-elect of IABR. Joachim Pleil Adjunct Professor, Department of Environmental Sciences and Engineering, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA. Joachim Pleil is adjunct professor at the University of North Carolina, School of Public Health, United States. He has published over 150 journal articles, many involving breath biomarker research and statistical interpretation of breath-based data. He has retired from US Environmental Protection Agency after 32 years as a research scientist. He is currently a consultant for NASA on a pilot breathing assessment project and is a founding member of IABR.