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Handbook of Proteolytic Enzymes. Volume 5: Inhibitors of Proteolytic Enzymes. Edition No. 4

  • Book

  • September 2026
  • Elsevier Science and Technology
  • ID: 6251175

Handbook of Proteolytic Enzymes, Fourth Edition, Volume Five: Inhibitors of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. This volume offers a thorough discussion of known naturally-occurring and synthetic inhibitors of proteolytic enzymes. Each chapter includes enzyme inhibitor names, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with color 2D and 3D structures of inhibitors, extensive references, and links to PubMed and MEROPS databases.

Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

Table of Contents

1. Protein Inhibitors and Their Clans
2. Mechanisms of Inhibition
3. SPINK1
4. Aprotinin
5. Alpha-1-Peptidase Inhibitor
6. Antithrombin
7. Plasminogen Activator Inhibitor-1
8. C1 Inhibitor
9. SerpinA12
10. Sunflower Cyclic Trypsin Inhibitor
11. Elafin
12. Cystatin B
13. Cystatin C
14. Cystatin F
15. Phytocystatin
16. Timp-1
17. Timp-2
18. Alpha-2-Macroglobulin
19. SPINK5 Protein
20. Tissue Factor Pathway Inhibitor-1
21. Hepatocyte Growth Factor Activator Inhibitor Type 2
22. Secretory Leukocyte Peptidase Inhibitor
23. Calpastatin
24. Synthetic Inhibitors of Metallopeptidases
25. Synthetic Inhibitors of Cysteine Peptidases
26. Synthetic Inhibitors of Serine Peptidases
27. Synthetic Inhibitors of Other Peptidases

Authors

Neil D. Rawlings Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.