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Handbook of Proteolytic Enzymes. Volume 4: Aspartic and Glutamic Peptidases, Asparagine Peptide Lyases and Peptidases of Unknown Catalytic Mechanisms. Edition No. 4

  • Book

  • September 2026
  • Elsevier Science and Technology
  • ID: 6251176

Handbook of Proteolytic Enzymes, Fourth Edition, Volume Four: Aspartic and Glutamic Peptidases, Asparagine Peptide Lyases and Peptidases of Unknown Catalytic Mechanisms includes over 250 chapters on known aspartic and glutamic peptidases, asparagine peptide lysases, and peptidases of unknown catalytic mechanisms. Chapters discuss each enzyme’s name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

Edited by world-renowned experts, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

Table of Contents

I. New Chapters
1. Candidapepsin SAP2
2. Signal Peptide Peptidase-Like Protein 2A

II. Major Revisions
3. Pepsin A
4. Chymosin
5. Renin
6. Cathepsin D
7. Cathepsin E
8. Phytepsin
9. Plasmepsin-2
10. BACE1 g.p. (Homo sapiens)
11. BACE2 g.p. (Homo sapiens)
12. HIV-1 Retropepsin
13. Presenilin 1

Authors

Neil D. Rawlings Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.