Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions explores how biological, genetic, and environmental factors affect cellular and systemic homeostasis and lead to accelerated aging. The book begins with a historical perspectives, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not be contributors. Subsequent chapters explore basic concepts and key accelerators in human biology, the role of biological clocks, and mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction.
The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.
The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.
Table of Contents
1. Aging: Concept of Biological Aging, Historical Perspective, and Impact of Aging on Health and Society2. Hallmarks of Aging: Exhibiting Characteristics That May or May Not Contribute to Accelerated Aging
3. Aging Accelerators: Basic Concept, Key Accelerators in Human Biology, and Molecular Basis of Aging Accelerators
4. Biological Clocks and Accelerated Aging: Understanding the Timers of Life
5. Mechanisms of Aging Accelerators: Cellular Senescence, DNA Damage, Epigenetic Changes, Mitochondrial Dysfunction, and Stem Cell Exhaustion
6. Diverse Timelines: How Different Organs Age at Different Rates
7. Accelerated Aging: The Brain's Role as the Body's Aging Integrator
8. Oxidative Stress: How It Accelerates Aging
9. Obesity Accelerates Aging
10. Chronic Inflammation as an Accelerator of Aging
11. Stress, Anxiety Disorder, and Depression Accelerate Aging
12. Physical and Environmental Factors Accelerate Aging
13. Role of Socioeconomic, Social, Demographic, and Biological Factors in Accelerating Aging
14. Dietary and Lifestyle Factors Accelerate Aging
15. Mitogenic Factors Accelerate Aging
16. Vitamin D Deficiency as Potential Factor to Accelerate Aging
17. Pharmacological and Nutraceutical Interventions to Prohibit Accelerated Aging
18. Lifestyle Modification and Dietary Supplements to Prevent Accelerated Aging
19. SIRTain Regulators of Accelerated Aging
20. Regenerative Medicine and Genetic Therapies as Regulators of Accelerated Aging
21. Current Research Trends, Emerging Technologies, and Future Directions for Prevention of Accelerated Aging
Authors
Sandeep Kumar Singh Department of Medical Biotechnology, All India Institute of Medical Sciences, Nagpur, MH, India.Dr. Sandeep Kumar Singh is Assistant Professor in the All India Institute of Medical Sciences (AIIMS), Nagpur, India. He obtained his PhD in Biotechnology from Banaras Hindu University and conducted postdoctoral research in the Department of Neurobiology at the University of Chicago. Dr. Singh brings 17 years of experience in neuroscience, molecular biology, neurodegenerative diseases, aging, nutraceuticals, and nanomedicines. He is a member of several scientific societies, including the American Academy of Neurology, International Society of Neurochemistry, Society of Neurochemistry, Indian Academy of Neurosciences, and Alzheimer's and related Disorders Society of India. Dr. Singh has published five books, including Elsevier's A New Era in Alzheimer's Research and Genome Editing for Neurodegenerative Diseases.
Shailendra Kumar Mishra Indian Scientific Education and Technology Foundation, Lucknow, Uttar Pradesh, India. Shailendra Kumar Mishra is co-founder of Indian Scientific Education and Technology (ISET) Foundation, a non-profit/non-governmental organization that persuades toward the science promotion. He is Molecular Human Genetics postgraduate, skilled in DNA Sequencing, Polymerase Chain Reaction (PCR), DNA & Plasmid isolation, Gel electrophoresis, Molecular hybridization, DNA elution from agarose gel, bacterial transformation, quantitation of DNA, DNA sequencing technique and versed in various diagnostic techniques. He did Master of Science in Molecular and Human Genetics from Jiwaji University, India, and research project from Banaras Hindu University, India. He has published his articles in some international and national journals such as Journal of Alzheimer's Disease and Parkinsonism and Nature India. His major interest is to understand the aging process through molecular basis that could be beneficial to cure age-related diseases.
