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Childhood Disorders of Rickets and Osteomalacia. A Comprehensive Review

  • Book

  • October 2026
  • Elsevier Science and Technology
  • ID: 6251197
Childhood Disorders of Rickets: A Comprehensive Review defines the pathophysiology of rickets and the various genetic and acquired conditions that present with rickets in childhood. This comprehensive review details the various forms of rickets, the histopathology, recent advances leading to new therapeutic options in treating rickets, and the role of Vitamin D and calcium in nutritional rickets. Additionally, the authors explore future research in various areas of nutritional and non-nutritional forms of rickets.

Written by global experts for clinicians and researchers treating and studying the various forms of rickets, the book will also be of interest to those working in public health and policy makers working on the prevention of nutritional rickets worldwide.

Table of Contents

1. Introduction to disorders of rickets
2. Pathophysiology of biomineralization
3. Phosphate homeostasis
4. Hypophsophataemia and rickets
5. Vitamin D deficiency rickets and osteomalacia
6. Vitamin D deficiency rickets and public health
7. Calcium deficiency rickets
8. Vitamin D dependent rickets
9. Overview of phosphopaenic forms of rickets
10. X-linked hypopshophataemia and rickets
11. Other (non XLH) forms of FGF23 mediated hypophosphatemic rickets
12. Non FGF23 mediated renal phosphate wasting disorders
13. Radiology of rickets
14. Radiological differential diagnosis of rickets
15. Histomorphometry of various forms of rickets

Authors

Suma Uday Birmingham Women's and Children's Hospital, UK.

Dr. Uday is an Honorary Clinical Associate Professor at the IMSR, University of Birmingham and a consultant endocrinologist at Birmingham Women's and Children's Hospital, Birmingham, UK, with an expertise in metabolic bone disease. Her PhD research focussed on nutritional rickets and its impact on public health policies in the UK. She has an interest in health inequalities and its impact on healthcare outcomes in children with bone disease and diabetes. Suma's interest in rare bone diseases include nutritional and non-nutritional forms of rickets and osteomalacia. Her research methodologies have included quantitative growth plate histology, in depth analysis of bone histomorphometry and mechanical testing of bone strength using three-point bending tests.