These insights are invaluable for inspiring new drug designs and therapeutic strategies. The book delivers a thorough overview of immunology, detailing the development and regulation of the immune system, with a special focus on cytokines. It presents an upgraded description of interleukins, immune-modulatory cytokines, and chemokines, exploring their structure, sources, functions, receptors, disease associations, and therapeutic potentials. This edition also introduces the latest information on innate lymphoid cells and their cytokines, as well as their adaptive immunity counterparts. A dedicated chapter on the cytokine storm provides critical insights into this phenomenon.
Table of Contents
1. Introduction: Common Features About Cytokines2. The Immune System: Definition and Development of Immunity
3. Activation of Cells of the Immune System
4. The Role and Regulation of the Immune Responses
5. Innate Immunity Cytokines with Pro- and Anti-inflammatory Activities
6. Innate Immunity Cytokines with Antiviral Properties: Interferons
7. Cytokines Shaping Adaptive T and B Cell Responses
8. Chemokines: Cytokines Controlling Cellular Migrations
9. Cytokine Networks and Cytokine Storm
10. Theories About the Function of the Immune System
Authors
Zlatko Dembic Professor Emeritus, University of Oslo, Norway.Dr. Zlatko Dembic, a distinguished scientist and medical doctor, has dedicated his career to exploring the intersections of medicine and biology, particularly in molecular and cellular immunology. Over the last two decades of the 20th century, he worked at prestigious institutions such as the Max-Planck-Institute for Biology in Germany, the Basel Institute for Immunology in Switzerland, and Hoffman-La Roche AG. His team was the first to identify genes underlying T-cell specificity and recognition, and they led the molecular cloning of key human cytokine receptors like the interferon-gamma receptor and the tumor necrosis factor receptor-2. In 1995, Dr. Dembic joined the Institute of Immunology at the University of Oslo, expanding his research to include T-cell development, cancer immunobiology, and immunogenetics. He proposed the "integrity" model of the immune system, emphasizing immunity's role in defense and symbiont selection and has over 100 scientific publications in many high impact factor scientific journals.
