Structural and Functional Dynamics of Nontuberculous Mycobacterium Proteins: Insights into Pathogenic Mechanisms explores the structural and functional dynamics of nontuberculous mycobacterium (NTM) proteins, focusing on their roles in pathogenicity, the mechanisms underlying microbial infections, and the potential for developing targeted therapeutic strategies to combat these emerging pathogens. The book begins with a foundational overview of nontuberculous mycobacteria (NTM), distinguishing them from Mycobacterium tuberculosis, their epidemiology, clinical significance, and structural biology. It discusses key structural features of NTM proteins and advanced techniques for protein structure determination, proteomic analyses, and bioinformatics approaches.
Additional sections investigate the pathogenic mechanisms and the complexities of the host-pathogen interaction. Concluding with insights into emerging research, interdisciplinary collaboration, future treatment, and prevention strategies, this book is a helpful resource for researchers and healthcare professionals engaged in the study of infectious diseases.
Additional sections investigate the pathogenic mechanisms and the complexities of the host-pathogen interaction. Concluding with insights into emerging research, interdisciplinary collaboration, future treatment, and prevention strategies, this book is a helpful resource for researchers and healthcare professionals engaged in the study of infectious diseases.
Table of Contents
1. Introduction to Nontuberculous Mycobacterium (NTM)2. Key Structural Features of NTM Proteins
3. Pathogenic Mechanisms of Nontuberculous Mycobacteria
4. Virulence Factors of Nontuberculous Mycobacterium
5. Antibiotic Resistance in Nontuberculous Mycobacteria
6. Future Directions and Emerging Research in Nontuberculous Mycobacteria
7. Perspectives on the Future of Treatment and Prevention Strategies
Authors
Parissa Farnia Director, Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), WHO Collaborating Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Dr. Parissa Farnia is the Director of the Iranian National Reference Tuberculosis Laboratory (INRT) at the Mycobacteriology Research Center (MRC) in the National Research Institute of Tuberculosis and Lung Disease (NRITLD). Her expertise and research interests include mycobacteriology, infectious diseases, and tuberculosis. She has published in multiple international journals such as Journal of Clinical Microbiology, Chest, Clinical infectious Diseases, and the International Journal of Tuberculosis and Lung Disease and serves on several editorial boards including International Journal of Mycobacteriology, the Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, and the Biomedical and Biotechnology Research Journal. Ali Akbar Velayati Director, National Research Institute of Tuberculosis and Lung Disease (NRITLD), WHO Collaborating Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Dr. Ali Akbar Velayati is the Director of the National Research Institute of Tuberculosis and Lung Diseases (NRITLD) at the Shahid Beheshti University of Medical Sciences. He is a Full Professor of Pediatric Infectious Diseases, and he has guided more than 300 MD and PhD students. He is also the Head of Mycobacteriology Research Center (MRC) in NRITLD, where he directly monitors the basic and clinical trial on tuberculosis. Dr. Velayati is the President of the Asian African Society of Mycobacteriology and of the Society of Biomedical and Biotechnology Scientists. He is the Chief Editor of the International Journal of Mycobacteriology, the Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, and the Biomedical and Biotechnology Research Journal. Poopak Farnia Associate Professor in Biotechnology, Tissue Engineering and Stem Cells Unit, Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Poopak Farnia is currently an Associate Professor in the Biotechnology, Tissue Engineering and Stem Cells Unit of the Mycobacteriology Research Center at the National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences in Tehran, Iran. Jalaledin Ghanavi Associate Professor and the Head of the Department of Tissue Engineering and Experimental Medicine, Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Jalaledin Ghanavi, MD, is surgeon, an Associate Professor, and the Head of the Department of Tissue Engineering and Experimental Medicine in the Mycobacteriology Research Center at the National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences in Tehran, Iran. He received the MD degree from the Isfahan University of Medical Science and has medical expertise in general medicine and general surgery. His ongoing research interests include tissue engineering, nanoarchitectonics, biomedicine, and nanomedicine, and he holds five U.S patents.
