Epigenetics and miRNA in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications explores the crucial role of epigenetic modifications and microRNAs in the onset, progression, and treatment of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, ALS, and Huntington’s disease. This comprehensive book bridges cutting-edge molecular research with real-world clinical applications, covering biomarker discovery, novel therapeutics, gene editing, and AI-driven bioinformatics. With clear explanations, case studies, and future perspectives, it serves as an essential resource for researchers, clinicians, and biotech professionals working toward innovative solutions for neurodegenerative disease diagnosis and treatment
Table of Contents
Section I: Fundamentals of Epigenetics and miRNA in Neurodegeneration1. Introduction to Epigenetics and miRNA in neurodegenerative diseases
2. Epigenetic Mechanisms in the Nervous System
3. miRNA Biogenesis and Function in Brain Health
Section II: Epigenetics and miRNA in Specific Neurodegenerative Disorders
4. Alzheimer’s Disease: Epigenetic and miRNA Contributions
5. Parkinson’s Disease: The Role of Epigenetic Modifications
6. Huntington’s Disease: Epigenetic and Post-Transcriptional Control
7. Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD): Molecular Crosstalk
8. Multiple Sclerosis: Epigenetic and miRNA Influence on Neuroinflammation
Section III: Translational and Clinical Applications
9. Epigenetic Biomarkers in Neurodegenerative Diseases
10. miRNA-Based Therapeutics: Challenges and Opportunities
11. Pharmacological and Nutritional Epigenetics in Neuroprotection
12. Gene Editing and Epigenetic Engineering Approaches
13. Artificial Intelligence and Computational Epigenomics in Neurodegeneration
Section IV: Future Perspectives and Ethical Considerations
14. Personalized Medicine in Neurodegenerative Diseases: The Role of Epigenetics and miRNA
15. Ethical, Legal, and Social Implications of Epigenetic and miRNA-Based Therapies
Authors
Lance R. McMahon Texas Tech University, USA. Lance R. McMahon, Ph.D., serves as the Executive Vice President for Research and Innovation at Texas Tech University Health Sciences Center. In his position, Dr. McMahon will serve as chair of the Research Council. Additionally, he has a faculty appointment in the Jerry H. Hodge School of Pharmacy. Dharmendra Kumar Khatri Associate Professor in the Department of Pharmacology, NIMS Institute of Pharmacy at NIMS University Rajasthan, Jaipur, India..Dr. Dharmendra Kumar Khatri is an Associate Professor in the Department of Pharmacology, NIMS Institute of Pharmacy at NIMS University Rajasthan, Jaipur, India.
Balachandar Vellingiri Associate Professor, Neurobiology (Ageing and Pediatric) Laboratory [NAP Lab], Department of Zoology, School of Basic Sciences, Central University of Punjab, Bathinda, Punjab, India.Dr. Balachandar Vellingiri currently is investigating various neurological diseases and developing human induced pluripotent stem cells (HiPSCs). Exploring the cutting-edge molecular, cellular, and translational neuroscience approaches, he aims to unravel disease mechanisms, identify therapeutic targets, and develop innovative interventions to slow or reverse neurological diseases. His expertise is on several techniques such as molecular cytogenetics, pathway analysis, and techniques in developing HiPSCs and Brain organoids, especially for neurological diseases.
