The book also addresses neurodevelopmental disorders like cerebral palsy, epilepsy, and autism, psychiatric disorders such as schizophrenia and thought disorders, and the molecular biology of memory and age-related cognitive decline. Organized into five sections, the book includes chapters on the latest techniques for brain analysis, genetic diagnostics, neurodevelopmental and psychiatric disorders, aging-related impairments, and new therapeutic approaches. Key topics include brain regions and circuits, new methods for studying these areas, and the relevance of this information for accurate diagnosis and patient care.
Table of Contents
Section 1: Advances in Analyses of Structures and Functions in Brain1. Electrophysiology and key discoveries
2. Ion channels and brain activity
3. Cortical Circuits structures and analyses
4. Neurotrophins
Section 2: Genetic and Genomic Diagnostic Techniques
5. Chromosome studies and microarrays
6. Gene sequencing exome sequencing genomic sequencing
7. RNA and transcription analyses 8. Metabolite analyses
Section 3: Neurodevelopmental Disorders
9. Neurodevelopmental defects
10. Cerebral Palsy and Movement disorders
11. Epilepsy
12. Developmental delay
13. Behavioral disorders including autism and attention deficit hyperactivity disorders
Section 4: Psychiatric Disorders
14. Transdiagnostic dimensions, maladaptive behaviors, distress
15. Thought disorders
16. Cross-disorder psychiatry
17. Schizophrenia
18. Genetics and Genomics in Psychiatry
Section 5: Impaired Function in Aging
19. Molecular biology of memory
20. Age related memory decline hippocampus and synaptic impairment and high risk genes
21. Mitochondrial functional impairment in aging
22. Alzheimer disease and risk loci
23. Epigenetic and transcription changes in aging
24. Dementia and neuropathology
25. Gene defects leading to abnormal protein aggregates
26. Fronto-temporal dementia
27. Vascular dementia
28. Parkinsonism and related gene defects
29. Amyotrophic lateral sclerosis
30. Vascular dementia
31. Macular degenerations and advances in therapy
Authors
Moyra Smith Professor Emerita, Department of Pediatrics and Human Genetics, College of Health Sciences, University of California, Irvine, CA, USA.Dr. Moyra Smith is a Professor Emerita in the Department of Pediatrics and Human Genetics, College of Health Sciences, at the University of California, Irvine, and in past years has held appointments at the National Institutes of Health and Johns Hopkins University. In 2017, the UCI Emeriti Association awarded Dr. Smith the UCI Outstanding Emerita Award in recognition of her continuing research on genetics and genomics, strong record of publications, active engagement with programs in the Department of Pediatrics, mentoring of graduate students, and involvement with the CART Autism Center at UCI. Dr. Moyra Smith has published more than 100 scientific articles in peer-reviewed journals such as Frontiers in Molecular Biosciences, Molecular Psychiatry, the Journal of Medical Genetics (JMG), and Cytogenetics Cell Genetics.
