Animal Models of Disease, Part F, Volume 212 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.
Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.
Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.
Table of Contents
1. Comprehensive Methods for Pain Assessment in RodentsMario Garc�a Dom�nguez
2. Orthotopic pleural mesothelioma mouse model
Fernando Aranda, Pedro Berraondo and Miguel Sanmamed
3. Liver Metastasis Model Using Spleen Injection of MC38 Cells
Fernando Aranda and Pedro Berraondo
4. Orthotopic murine model of hepatocellularcarcinoma
Marta Ruiz, Leyre Silva and David Rep�raz
5. Study of bone metastases in lung cancer: Intratibial model
Karmele Karmele
6. Live imaging of human colon cancer organoids/tumor associated fibroblasts and T cells for the study the effects of immunotherapies
Alvaro Teijeira, Mercedes Leal-G�mez, In�s Antom�s, Maria Lucia Chiclana and Itziar Migueliz
7. Generation of 3D Organoids from DMBA/TPA-treated mice
Marta Montes and Niloufar Hosseini-Giv
8. The chorioallantoic membrane (CAM) assay as an in vivo model for B cell lymphoma
Laura Mondragon, Manon Durand, Barbara Chalhoub, Paula Carrasco, Arnau Juli� Carbonell and Ga�tan Jego
9. An orthotopic model of pancreatic cancer for radiotherapy research
Juan Dubrot, Paolo Wong, Cristina Sainz, Myriam Fernandez-Sendin, Iratxe Ugarte and Ainhoa Andueza
10. Refine mouse models of liver carcinogenesis: versatility and clinical relevance
Maite G. Fernandez-Barrena
11. Orthotopic ovarian cancer model
Fernando Aranda
12. Preclinical Models to Induce and Study Acute Liver Failure
Marco Cordani
13. Preclinical Models to Induce and Study Liver Fibrosis and Cirrhosis
Marco Cordani
14. Preclinical Models to Establish and Study Fatty Liver Diseases
Marco Cordani
15. Experimental Methods to Study Liver Injury and Recovery in Preclinical Models
Marco Cordani
16. Ethical Considerations and Regulatory Translation in Developing and Application of Preclinical Models
Marco Cordani
17. Visualization of antigen display by follicular dendritic cells after vaccination
Ana Martinez Ria�o
