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Special Hematology Laboratory Testing: Emerging Concepts and Novel Approaches, An Issue of the Clinics in Laboratory Medicine. The Clinics: Internal Medicine Volume 45-4

  • Book

  • November 2025
  • Elsevier Health Science
  • ID: 6251988
In this issue of Clinics in Laboratory Medicine, guest editors Drs. Fabienne Lucas and Daniel Sabath bring their considerable expertise to the topic of Special Hematology Laboratory Testing: Emerging Concepts and Novel Approaches. Top experts cover emerging concepts such as DIC and advances in D-dimer testing, novel therapies and gene therapy for hemophilia, and how AI can support diagnosis and management of clotting disorders.- Contains 12 relevant, practice-oriented topics including the viscoelastic testing/ viscoelastic hemostatic assays: technology and clinical applications; high throughput sequencing in the diagnosis of inherited blood, thrombotic and platelet disorders; novel laboratory correlations for primary antiphospholipid syndrome; inhibitors in hemophilia; machine-learning and AI-based clinical decision support for the diagnosis and management of clotting and bleeding disorders; and more- Provides in-depth clinical reviews on special hematology laboratory testing: emerging concepts and novel approaches, offering actionable insights for clinical practice- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews

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Table of Contents

Implementation of Viscoelastic Testing at the Point of Care: Practical Pearls for Clinical Integration
Flow Cytometry Assessment of Platelet Phenotype, Function, and Cellular Interactions: Guidelines for Optimization and Assay Performance
Platelet Subpopulations: Characteristics, Function, Clinical Relevance, and Translational Potential
High-throughput Sequencing in the Diagnosis of Inherited Bleeding and Clotting Disorders: Technical and Interpretive Considerations Necessary for Accurate Reporting and Clinical Application
von Willebrand Disease and von Willebrand Factor: Laboratory Standards and Methods Regarding von Willebrand Factor Activity Assays, von Willebrand Factor Propeptide Assays, and Multimer Methodology
Disseminated Intravascular Coagulation and Advances in D-Dimer Testing: Progress in Harmonization of Clinical Assays and Innovative Detection Methods
Novel Clinical and Laboratory Correlations for Antiphospholipid Syndrome
Hemostatic Disorders Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection, COVID-19 Vaccination, and Long-COVID Syndrome: Current Evidence and Controversies in Clinical Practice
Recent Advances in Extended Half-Life Products, Nonfactor Replacement Therapies, and Gene Therpy for the Treatment of Hemophilia
Women’s and Transgender Issues in Thrombosis and Hemostasis: Laboratory Parameters of Coagulation and Fibrinolysis Influenced by Hormones, Including Pregnancy and Postpartum
Machine Learning and Artificial Intelligence-Based Clinical Decision Support for Modern Hematology

Authors

Fabienne Lucas Assistant Professor of Hematopathology, Associate Director of Hematology/Coagulation, Department of Laboratory Medicine and Pathology, UW Medicine, Seattle, WA, USA. Daniel E. Sabath Professor Head of Hematology Division Department of Laboratory Medicine and Pathology Chief of Service, Harborview Clinical Laboratories Laboratory Director, Hematology and Coagulation UW Medical Center, Seattle, WA, USA.