Written and edited by the world’s foremost experts on stroke, this comprehensive text brings you fully up to date with current research findings and management approaches for cerebrovascular disease. Stroke: Pathophysiology, Diagnosis, and Management, 8th Edition, has been fully revised to cover every aspect of this rapidly advancing field, and remains an indispensable resource for stroke specialists, general neurologists, and other medical professionals who have an interest in stroke. It provides expert clinical guidance, comprehensive pathophysiology coverage, data from recent trials, new research findings and guidelines, advances in diagnostic tests, full-color illustrations, and much more, for a complete picture of today’s stroke medicine.
- Covers all aspects of stroke, including pathophysiology, epidemiology, and risk factors; medical therapy, including rehabilitation, recovery, and secondary prevention; interventional therapy; surgical therapy; and more
- Features a completely revised pathophysiology section with the latest understanding of underlying cellular and vascular biology and genetic aspects of cerebrovascular diseases
- Helps you recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan
- Contains expanded sections on Secondary Prevention and Rehabilitation and Recovery, and a new chapter on Artificial Intelligence
- Keeps you abreast of the overwhelming volume of new clinical trials and other clinical and translational research in all aspects of this dynamic field, providing clear summaries and practical evaluations of all relevant data
- Includes review and application of updated guidelines on stroke prevention and treatment
- Provides access to lecture slides covering basic science, case studies, and interventional treatment overviews
- Features a Key Points summary at the beginning of each chapter so you can quickly identify important information
- Offers full-color visual guidance with abundant imaging (MRI, CT, echocardiogram, Doppler waveforms), clinical photographs, pathology slides and stains, anatomical illustrations, diagrams, charts, and tables to enhance understanding and support accurate diagnoses
- Shares experience and knowledge from an expert editorial and author team, including four new editors who bring their personal expertise to key areas: Drs. Valeria A. Caso, Nicole R. Gonzales, Tatjana Rundek, and Sean I. Savitz
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date
Table of Contents
1. Cerebral Vascular Biology in Health and Disease2. Mechanisms of Thrombosis and Thrombolysis
3. Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease 4. Histopathology of Brain Tissue Response to Stroke and Injury
5. Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death
6. Intracellular Signaling : Mediators and Protective Responses
7. The Neurovascular Unit and Responses to Ischemia
8. Mechanisms of Damage After Cerebral Hemorrhage
9. White Matter Pathophysiology
10. Inflammation and Immune Response
11. Mechanisms of Plasticity Remodeling and Recovery
12. Genetics and Vascular Biology of Brain Vascular Malformations
13. Gliovascular Mechanisms and White Matter Injury in Vascular Cognitive Impairment and Dementia
14. Global Burden of Stroke
15. Stroke Disparities
16. Risk Factors and Prevention
17. Prognosis After Stroke
18. Vascular Dementia and Cognitive Impairment
19. Genetic Basis of Stroke Occurrence, Prevention, and Outcome
20. Classification of Ischemic Stroke
21. Clinical Scales to Assess Patients With Stroke
22. Carotid Artery Disease
23. Anterior Cerebral Artery Disease
24. Middle Cerebral Artery Disease
25. Posterior Cerebral Artery Disease
26. Vertebrobasilar Disease
27. Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small-Vessel Disease
28. Intracerebral Hemorrhage
29. Aneurysmal Subarachnoid Hemorrhage
30. Arteriovenous Malformations and Other Vascular Anomalies
31. Stroke and Other Vascular Syndromes of the Spinal Cord
32. Cardiac Diseases
33. Atherosclerotic Disease of the Proximal Aorta
34. Stroke Related to Surgery and Other Procedures
35. Arterial Dissection, Fibromuscular Dysplasia, and Carotid Webs
36. Inflammatory and Infectious Vasculopathies
37. Reversible Cerebral Vasoconstriction Syndromes 38. Posterior Reversible Encephalopathy Syndrome
39. Stroke and Substance Abuse
40. Moyamoya Disease
41. Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy 42. Hematologic Disorders and Stroke
43. Migraine and Stroke
44. Cryptogenic Stroke
45. Cerebral Venous Thrombosis
46. Ultrasonography
47. Computed Tomography-Based Evaluation of Cerebrovascular Disease
48. Magnetic Resonance Imaging of Cerebrovascular Diseases
49. Cerebral Angiography
50. OMICs in Stroke: Insight Into Stroke Through Epigenomics, Transcriptomics, Proteomics, Lipidomics, and Metabolomics
51. Stroke Systems of Care and Impact on Acute Stroke Treatment
52. Prehospital and Emergency Department Care of the Patient With Acute Stroke
53. Intravenous Thrombolysis
54. Antithrombotic Therapy for Treatment of Acute Ischemic Stroke
55. General Stroke Management and Stroke Units 56. Critical Care of the Patient With Acute Stroke
57. Pharmacologic Modification of Acute Cerebral Ischemia
58. Treatment of “Other” Stroke Etiologies
59. Medical Therapy of Intracerebral and Intraventricular Hemorrhage
60. Rehabilitation and Recovery of the Patient With Stroke
61. Interventions to Improve Recovery After Stroke
62. Enhancing Stroke Recovery With Cellular Therapies
63. Antiplatelet Therapy for Secondary Prevention of Stroke
64. Secondary Prevention of Cardioembolic Stroke
65. Design of Stroke-Related Clinical Trials
66. Endovascular Therapy of Extracranial and Intracranial Occlusive Disease
67. Endovascular Treatment of Acute Ischemic Stroke
68. Endovascular Treatment of Intracranial Aneurysms
69. Interventional Therapy of Brain and Spinal Arteriovenous Malformations
70. Dural Arteriovenous Malformations
71. Surgery of Anterior and Posterior Aneurysms
72. Surgery for Intracerebral Hemorrhage
73. Management of Intraventricular Hemorrhage
74. Surgical Management of Cranial and Spinal Arteriovenous Malformations
75. Surgical Management of Cavernous Malformations and Venous Anomalies
76. Indications for Carotid Endarterectomy in Patients With Asymptomatic and Symptomatic Carotid Stenosis
77. Extracranial-Intracranial Bypass for Cerebral Ischemia
78. Decompressive Craniectomy for Infarction and Intracranial Hemorrhages
Authors
James C. Grotta Director, Stroke Program, Memorial Hermann - Texas Medical Center; Professor of Neurology; Chairman, Department of Neurology, University of Texas Medical School at Houston, Houston, TX, USA. Professor of Neurology, Chairman, Department of Neurology, University of Texas Medical School at Houston; Director, Stroke Program, Memorial Hermann - Texas Medical Center, Houston, TX Sean I. Savitz Professor of Neurology, Frank M. Yatsu Chair, Director of the Institute for Stroke and Cerebrovascular Disease at University of Texas Health Science Center at Houston; Stroke Medical Director, Memorial Hermann Healthcare System, Houston, Texas. Gregory W. Albers Director, Stanford Stroke Center; Coyote Foundation Professor of Neurology and Neurological Sciences, USA. Joseph P. Broderick Director of the Greater Cincinnati-Northern Kentucky Stroke Team; Professor and Chairman, University of Cincinnati, Department of Neurology and Rehabilitation Medicine, Cincinnati, OH, USA. Valeria A. Caso Chief of Neurology-Stroke Unit, Saronno Hospital (ASST Valle Olona), Saronno, Italy. Arthur L. Day Professor, Vivian L. Smith Department of Neurosurgery, McGovern Medical School, UTHealth, Houston, USA.Arthur L. Day, MD, is a board-certified and fellowship-trained neurosurgeon with specific cerebrovascular and skull-base neurosurgery expertise. He specializes in the microsurgical treatment of brain tumors and minimally invasive spinal surgery. Dr. Day is also a professor in the Vivian L. Smith Department of Neurosurgery at McGovern Medical School at UTHealth Houston.
Nicole R. Gonzales Professor & Co-Director for Diversity, Equity and Inclusion, Department of Neurology, University of Colorado Anschutz, Aurora, Colorado. Scott E. Kasner Professor of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. Eng H. Lo Professor of Neurology and Radiology, Harvard Medical School, Research Staff, Mass General Hospital, Massachusetts General Hospital, Neuroprotection Research Lab, Charlestown, MA, USA. Eng H. Lo is a basic neurovascular scientist. He helped develop the neurovascular unit concept (Lo, Nat Rev Neurosci 2003; Tiedt et al, Nat Rev Neurol 2022). Tatjana Rundek Professor of Neurology, Evelyn F. McKnight Chair for Learning and Memory in Aging, Scientific Director of the Evelyn F. McKnight Brain Institute; Executive Vice Chair of Research and Faculty Affairs, Neurology, and Director, Clinical and Translational Research Division; Director, Master of Science in Clinical Translational Investigations, Miller School of Medicine at University of Miami, Miami, Florida.
