Protein Expression: Global Markets

  • ID: 4750819
  • Report
  • Region: Global
  • 154 Pages
  • BCC Research
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FEATURED COMPANIES

  • Abnova (Taiwan) Corp.
  • Agilent Technologies Inc.
  • Domainex Ltd.
  • Genscript
  • Merck Kgaa
  • Promega Corp.
  • MORE

Report Scope:

This research report presents an in-depth analysis of the global market for protein expression by system type, products and services, applications, end users and regional markets. The report includes key protein expression systems that are incorporated in several therapeutic treatment methods. It discusses the role of supply chain members from manufacturers to researchers. The report provides an in-depth analysis of key companies operating in the global market for protein expression. A patent analysis focuses on describing technological trends across periods of time and regions, such as the U.S., Europe and Japan.

The protein expression market is mainly segmented into the following system types: prokaryotic expression systems, mammalian cell expression systems, insect cell expression systems, yeast expression systems, cell-free expression systems and algal-based expression systems. This market is further segmented based on products and services into reagents, expression vectors, competent cells, instruments and services. The market study details end users and applications, and ongoing activity in the research and development area. The market is segmented by region into North America, Europe, Asia-Pacific and the rest of the world (ROW). Companies profiled in this report include Thermo Fisher Scientific Inc., Merck KGaA, Promega Corp., Agilent Technologies, GenScript, Takara Holdings Inc., Bio-Rad Laboratories Inc., Qiagen N.V., Lonza and others.

The Report Includes:

  • 45 data tables 34 additional tables
  • An overview and in-depth analysis of the global markets for protein expression technologies
  • Analyses of global market trends with data from 2016 and 2017, and projections of compound annual growth rates (CAGRs) through 2022
  • Discussion on perfusion approaches and supporting practices such as continuous biomanufacturing, and digital and model-based controls
  • Identification of key market dynamics and the factors impacting the global market for protein expression and its sub-segments
  • Regional dynamics of the global protein expression market and analysis of trends and opportunities in major regions covering North America, Europe, Asia-Pacific and the rest of the world (ROW)
  • A relevant patent analysis focuses on describing technological trends across periods of time and regions, such as the U.S., Europe and Japan
  • Detailed analysis of the cloning technologies, production of recombinant proteins and problems associated with protein production
  • Assessment of major stakeholders, product portfolios and recent developments and the competitive landscape among market leaders
  • Company profiles of leading global payers, including Agilent Technologies, Bio-Rad Laboratories Inc., Merck KGaA, Promega Corp., GenScript, Thermo Fisher Scientific Inc., and Qiagen N.V.
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FEATURED COMPANIES

  • Abnova (Taiwan) Corp.
  • Agilent Technologies Inc.
  • Domainex Ltd.
  • Genscript
  • Merck Kgaa
  • Promega Corp.
  • MORE

Chapter 1 Introduction

  • Study Goals and Objectives
  • Reasons for Doing This Study
  • Scope of Report
  • Information Sources and Methodology
  • Intended Audience
  • Geographic Breakdown
  • Analyst's Credentials
  • Custom Research
  • Related Reports

Chapter 2 Summary and Highlights

Chapter 3 Market and Technology Background

  • Market Definition
  • Protein Expression Market Overview
  • Choice of Cell Type
  • Choice of Plasmid
  • Choice of Cell Expression System
  • Introduction to Protein Expression Systems
  • Protein Synthesis Machinery
  • What is Protein Expression?
  • How Proteins Are Made
  • Transcription and Translation
  • Perfusion Approaches and Supporting Practices (e.g., Continuous BioManufacturing and Digital and Model-based Controls)
  • Post-translational Modification
  • Cloning Technologies
  • Constitutive and Inducible Promoters Commonly Used in Recombinant Protein Expression Systems
  • Production of Recombinant Proteins
  • Recombinant Protein Expression Methods
  • Why Produce Proteins Recombinantly?
  • Comparison of Expression Systems
  • Post-translational Processing
  • Problems Associated with the Production of Protein
  • Loss of Expression
  • Ongoing Clinical Trials for Protein Expression
  • Market Dynamics
  • Drivers
  • Restraints
  • Opportunities

Chapter 4 Global Market for Protein Expression Systems by Type

  • Introduction
  • Constitutive and Inducible Promoters Commonly Used in Recombinant Protein Expression Systems
  • Characteristics of Various Recombinant Protein Expression Systems
  • Prokaryotic Expression Systems
  • Promoters
  • E. coli Systems
  • Other Prokaryotic Expression Systems
  • Mammalian Cell Expression Systems
  • Mammalian Expression Vectors Characteristics
  • Chinese Hamster Ovary (CHO) Systems
  • Other Mammalian Cell Systems
  • Insect Cell Expression Systems
  • Baculovirus Systems
  • Yeast Expression Systems
  • K. Lactis Systems
  • Saccharomyces Systems
  • Pichia Systems
  • Cell-Free Expression Systems
  • Algal-Based Expression Systems

Chapter 5 Global Market for Protein Expression by Products and Services

  • Overview
  • Reagents
  • Acids and Bases
  • Acrylamides
  • Buffers/Buffer Salts
  • Cell Lysis
  • Detergents
  • General Reagents
  • Labware
  • Protease Inhibitors
  • Solvents
  • Expression Vectors
  • Commonly Used Expression Hosts
  • Competent Cells
  • Instruments
  • Bioreactor Systems
  • Services
  • Protein Expression Services
  • Benefits
  • Specific Services Provided by Organizations

Chapter 6 Global Market for Protein Expression by Application

  • Introduction
  • Medicine
  • Research
  • Biotechnology
  • Therapeutic
  • Traditional Recombinant and Newer Cell Therapies including Stem Cell
  • Industrial
  • Research

Chapter 7 Global Market for Protein Expression by End User

  • Overview
  • Pharmaceutical and Biotechnology Companies
  • Academic Research Institutes
  • Contract Research Organizations
  • Others

Chapter 8 Global Market for Protein Expression by Region

  • North America
  • U.S.
  • Canada
  • Mexico
  • Europe
  • U.K.
  • Germany
  • France
  • Rest of Europe
  • Asia-Pacific
  • China
  • Japan
  • Australia
  • India
  • South Korea
  • Taiwan
  • Rest of Asia
  • ROW
  • Brazil
  • Saudi Arabia
  • South Africa
  • Others

Chapter 9 Government Regulations

  • General Manufacturing Guidelines
  • Control of Starting/Source Materials
  • Expression Vector and Host Cell
  • Cell Bank System
  • Cell Culture Medium/Other Materials
  • Control of the Manufacturing Process
  • Cell Culture
  • Purification
  • Control of Drug Substance and Drug Product
  • Characterization
  • Routine Control

Chapter 10 Patent Review

  • Patent Analysis
  • Patents and Patent Applications Filed by Institutions

Chapter 11 Competitive Landscape

  • Acquisition
  • Thermo Fisher Scientific Acquired Affymetrix
  • Product Launches

Chapter 12 Company Profiles

  • Abnova (Taiwan) Corp.
  • Accelagen Inc.
  • Agilent Technologies Inc.
  • Biomatik
  • Bio-Rad Laboratories Inc.
  • Domainex Ltd.
  • Enzo Life Sciences Inc.
  • Exon Biosystems
  • Genscript
  • Lonza Group Ag
  • Lucigen Corp.
  • Merck Kgaa
  • New England Biolabs Inc.
  • Novoprotein Scientific Inc.
  • Origene Technologies Inc.
  • Oxford Expression Technologies Ltd.
  • Promega Corp.
  • Proteogenix Inc.
  • Qiagen Inc.
  • R&D Systems Inc.
  • Sino Biological Inc.
  • Syngene
  • Synthetic Genomics Inc.
  • Takara Holdings, Inc.
  • Thermo Fisher Scientific Inc.

Chapter 13 Appendix: Uses of Protein Expressions Systems

List of Tables
Summary Table: Global Market for Protein Expression, by Region, Through 2022
Table 1: Advantages and Disadvantages of Protein Expression Systems
Table 2: Prokaryotes vs. Eukaryotes Protein Synthesis
Table 3: Comparison of Expression Systems
Table 4: Ongoing Clinical Trials (List 1)
Table 5: Ongoing Clinical Trials (List 2)
Table 6: Global Market for Protein Expression Systems, by Type, Through 2022
Table 7: Comparison of Protein Expression Systems and Their Respective Advantages and Disadvantages
Table 8: Uses of Constitutive and Inducible Promoters in Recombinant Protein Expression Systems
Table 9: Advantages, Challenges and Most Common Applications of Protein Expression Systems
Table 10: Global Market for Prokaryotic Expression Systems, by Region, Through 2022
Table 11: Overview of E. coli Promoter Systems Useful for Heterologous Protein Production
Table 12: Bacterial Strains for Protein Expression
Table 13: Global Market for Mammalian Cell Expression System, by Region, Through 2022
Table 14: Global Market for Insect Cell Expression Systems, by Region, Through 2022
Table 15: Global Market for Yeast Expression System, by Region, Through 2022
Table 16: Global Market for Cell-Free Systems, by Region, Through 2022
Table 17: Global Market for Algal Expression Systems, by Region, Through 2022
Table 18: Global Market for Protein Expression, by Products and Services, Through 2022
Table 19: Global Market for Reagents, by Region, Through 2022
Table 20: Products: Acids and Bases
Table 21: Products: Acrylamides
Table 22: Products: Buffers/Buffer Salts
Table 23: Products: Cell Lysis
Table 24: Products: Detergents
Table 25: Products: General Reagents
Table 26: Products: Labware
Table 27: Products: Protease Inhibitors
Table 28: Products: Solvents
Table 29: Global Market for Vector Products, by Region, Through 2022
Table 30: Characteristics of the Commonly Used Expression Hosts
Table 31: Global Market for Competent Cells Products, by Region, Through 2022
Table 32: Features of Component Cells
Table 33: Global Market for Instruments, by Region, Through 2022
Table 34: Global Market for Services, by Region, Through 2022
Table 35: Specific Services Provided by Organizations
Table 36: GenScript Services by Category of Protein Expression
Table 37: Global Market for Protein Expression, by Application, Through 2022
Table 38: Global Market for Therapeutic Applications, by Region, Through 2022
Table 39: Global Market for Industrial Applications, by Region, Through 2022
Table 40: Global Market for Research Applications, by Region, Through 2022
Table 41: Global Market for Protein Expression, by End User, Through 2022
Table 42: Global Market for Pharmaceutical End Users of Protein Expression, by Region, Through 2022
Table 43: Global Market for Academic Research Institute End Users of Protein Expression, by Region, Through 2022
Table 44: Global Market for Contract Research Organization End Users of Protein Expression, by Region, Through 2022
Table 45: Global Market for Other End Users of Protein Expression, by Region, Through 2022
Table 46: Global Market for Protein Expression, by Region, Through 2022
Table 47: North American Market for Protein Expression, by Country, Through 2022
Table 48: North American Market for Protein Expression, by Products, Through 2022
Table 49: North American Market for Protein Expression Systems, by Type, Through 2022
Table 50: North American Market for Protein Expression, by Application, Through 2022
Table 51: North American Market for Protein Expression, by End User, Through 2022
Table 52: European Market for Protein Expression, by Country, Through 2022
Table 53: European Market for Protein Expression, by Products and Services, Through 2022
Table 54: European Market for Protein Expression Systems, by Type, Through 2022
Table 55: European Market for Protein Expression, by Application, Through 2022
Table 56: European Market for Protein Expression, by End User, Through 2022
Table 57: Asia-Pacific Market for Protein Expression, by Country, Through 2022
Table 58: Asia-Pacific Market for Protein Expression, by Products and Services, Through 2022
Table 59: Asia-Pacific Market for Protein Expression Systems, by Type, Through 2022
Table 60: Asia-Pacific Market for Protein Expression, by Application, Through 2022
Table 61: Asia-Pacific Market for Protein Expression, by End User, Through 2022
Table 62: ROW Market for Protein Expression, by Country, Through 2022
Table 63: ROW Market for Protein Expression, by Products and Services, Through 2022
Table 64: ROW Market for Protein Expression Systems, by Type, Through 2022
Table 65: ROW Market for Protein Expression, by Application, Through 2022
Table 66: ROW Market for Protein Expression, by End User, Through 2022
Table 67: Significant U.S. Patents and Patent Applications on Protein Expression, 2015-2018
Table 68: Significant European Patents and Patent Applications on Protein Expression, 2015-2018
Table 69: Significant Japanese Patents and Patent Applications on Protein Expression, 2015-2018
Table 70: U.S. Patents Filed on Protein Expression Technologies by Institutions, 2015-2018
Table 71: Abnova (Taiwan) Corp. Products
Table 72: Biomatik Products
Table 73: GenScript Products
Table 74: Lucigen Products
Table 75: Protein Production Service in HEK293 Cells
Table 76: Protein Production Service in E. coli Cells
Table 77: Protein Production Service in Insect Cell Culture/Baculovirus Expression
Table 78: CHO Cell Transient Transfection Service

List of Figures
Summary Figure: Global Market for Protein Expression, by Region, 2016-2022
Figure 1: Protein Expression Workflow
Figure 2: Share of Clinical Trials Performed for Protein Expression, by Region, 2009-2018
Figure 3: Patents Shares of Protein Expression Technologies, by Region, 2015-2018

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FEATURED COMPANIES

  • Abnova (Taiwan) Corp.
  • Agilent Technologies Inc.
  • Domainex Ltd.
  • Genscript
  • Merck Kgaa
  • Promega Corp.
  • MORE

Protein expression is a technique where three processes - translation, transcription and posttranslational modification - play a vital role in the various applications, including biologics production, therapeutic protein production and research application. There are three types of recombinant protein expression methods. These include in vivo protein expression, in vitro protein expression and chemical protein synthesis. It is critical to have access to a variety of expression tools to ensure the successful expression of the required target protein.

Based on the functional need in the host cell, proteins can be modified, regulated and synthesized in different living organisms. These proteins need a specific intracellular environment to achieve the required secondary and tertiary structures. Some proteins also require post-translational modifications or insertion into a cellular membrane to attain the proper functioning of the protein. In addition, the production of some proteins could also be toxic for the well-being of the host. Hence, there is no single solution for the successful production of different types of recombinant proteins.

In this report, the protein expression market is studied through different perspectives. The market is analyzed through the products and their applications in the treatment of several chronic diseases. The protein expression market is categorized into six types based on system type: prokaryotic expression system, mammalian cell expression system, insect cell expression system, yeast cell expression system, cell-free expression system and algal-based expression system.

The global market for protein expression based on products and services is segmented into five categories: reagents, expression vectors, competent cells, instruments and services. the reagents segment has dominated the global market for protein expression and is anticipated to do so during the forecast period.

By geography, the global market for protein expression is divided into North America, Europe, Asia-Pacific and the Rest of World (ROW). North America held the largest market share in 2016. Europe held the second-largest market share of the protein expression market globally.

Note: Product cover images may vary from those shown
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  • Abnova (Taiwan) Corp.
  • Accelagen Inc.
  • Affymetrix
  • Agilent Technologies Inc.
  • Biomatik
  • Bio-Rad Laboratories Inc.
  • Domainex Ltd.
  • Enzo Life Sciences Inc.
  • Exon Biosystems
  • Genscript
  • Lonza Group Ag
  • Lucigen Corp.
  • Merck Kgaa
  • New England Biolabs Inc.
  • Novoprotein Scientific Inc.
  • Origene Technologies Inc.
  • Oxford Expression Technologies Ltd.
  • Promega Corp.
  • Proteogenix Inc.
  • Qiagen Inc.
  • R&D Systems Inc.
  • Sino Biological Inc.
  • Syngene
  • Synthetic Genomics Inc.
  • Takara Holdings, Inc.
  • Thermo Fisher Scientific Inc.
Note: Product cover images may vary from those shown
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Note: Product cover images may vary from those shown
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