+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

Market Spotlight: Hidradenitis Suppurativa

  • Report

  • 33 Pages
  • February 2021
  • Region: Global
  • Citeline
  • ID: 4533485
This Market Spotlight report covers the Hidradenitis Suppurativa market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming events, probability of success, epidemiology, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.

Key Takeaways
  • All of the approved drugs for hidradenitis suppurativa (HS) target tumor necrosis factor-alpha. These therapies are administered via the subcutaneous route, while Humira is also available in an intravenous formulation.
  • The majority of industry-sponsored drugs in active clinical development for HS are in Phase II. Therapies in development for HS focus on a wide variety of targets. These therapies are administered via the oral, topical, intravenous, and subcutaneous routes.
  • High-impact upcoming events for drugs in the HS space comprise topline Phase II trial results for iscalimab, and topline Phase III trial results for bimekizumab and Cosentyx.
  • The overall likelihood of approval of a Phase I dermatology-general asset is 20.2%, and the average probability a drug advances from Phase III is 68%. Drugs, on average, take 8.8 years from Phase I to approval in the dermatology-general space, as well as in the overall dermatology space.
  • The distribution of clinical trials across Phase I–IV indicates that the majority of trials for HS have been in the early and midphases of development, with 86% of trials in Phase I–II, and only 14% in Phase III–IV.
  • The US has the lead in terms of the number of HS clinical trials globally. Germany leads the major European markets, while Japan has the top spot in Asia.
  • AbbVie has the highest number of ongoing clinical trials for HS, with two trials.
  • AbbVie is the only sponsor to have initiated a Phase III or Phase IV trial in HS

Table of Contents

OVERVIEWKEY TAKEAWAYS
DISEASE BACKGROUND
  • Subtypes

TREATMENTEPIDEMIOLOGYMARKETED DRUGSPIPELINE DRUGS
RECENT EVENTS AND ANALYST OPINION
  • Avacopan for HS (October 28, 2020)
  • Vilobelimab for HS (June 30, 2020)
  • Vilobelimab for HS (November 6, 2019)

KEY UPCOMING EVENTS
KEY REGULATORY EVENTS
  • Celltrion Wins Race For High-Concentration Adalimumab

PROBABILITY OF SUCCESS
LICENSING AND ASSET ACQUISITION DEALS
  • Sanofi Nabs Kymera IRAK4 Protein Degrader As It Continues To Build In I&I

REVENUE OPPORTUNITY
CLINICAL TRIAL LANDSCAPE
  • Sponsors by status
  • Sponsors by phase

BIBLIOGRAPHY
  • Prescription information

APPENDIX
LIST OF FIGURES
Figure 1: Overview of pipeline drugs for HS in the US
Figure 2: Pipeline drugs for HS, by company
Figure 3: Pipeline drugs for HS, by drug type
Figure 4: Pipeline drugs for HS, by classification
Figure 5: Avacopan for HS (October 28, 2020): Phase IIb - AURORA
Figure 6: Key upcoming events in HS
Figure 7: Probability of success in the dermatology-general pipeline
Figure 8: Clinical trials in HS
Figure 9: Top 10 drugs for clinical trials in HS
Figure 10: Top 10 companies for clinical trials in HS
Figure 11: Trial locations in HS
Figure 12: HS trials status
Figure 13: HS trials sponsors, by phase
LIST OF TABLES
Table 1: Marketed drugs for HS
Table 2: Pipeline drugs for HS in the US
Table 3: Avacopan for HS (October 28, 2020)
Table 4: Vilobelimab for HS (June 30, 2020)
Table 5: Vilobelimab for HS (November 6, 2019)
Table 6: Historical global sales, by drug ($m), 2015–19
Table 7: Forecasted global sales, by drug ($m), 2021–25